The mechanisms behind heatstroke-induced intestinal damage DOI Creative Commons
Meng Sun, Qin Li, Zhimin Zou

и другие.

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Окт. 28, 2024

Abstract With the frequent occurrence of heatwaves, heatstroke (HS) is expected to become one main causes global death. Being a multi-organized disease, HS can result in circulatory disturbance and systemic inflammatory response, with gastrointestinal tract being primary organs affected. Intestinal damage plays an initiating promoting role HS. Multiple pathways integrity intestinal epithelial barrier due heat stress hypoxia brought on by blood distribution. This usually leads leakage as well infiltration metastasis toxins pathogenic bacteria cavity, which will eventually cause inflammation whole body. A large number studies have shown that after involves body’s disruption oxidative balance, disorder tight junction proteins, massive cell death, microbial imbalance. Based these mechanisms, protecting regulating immune responses are effective treatment strategies. To better understand pathophysiology this complex process, review aims outline potential processes possible therapeutic strategies for recent years.

Язык: Английский

Caspase family in autoimmune diseases DOI

Wangzheqi Zhang,

Huang Wu,

Yan Liao

и другие.

Autoimmunity Reviews, Год журнала: 2024, Номер 24(2), С. 103714 - 103714

Опубликована: Дек. 3, 2024

Язык: Английский

Процитировано

4
Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease DOI
Yuting Jiang, Jie Chen,

Yaoyao Du

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 154, С. 114462 - 114462

Опубликована: Апрель 7, 2025

Язык: Английский

Процитировано

0
Identification of necroptosis‐related genes in ankylosing spondylitis by bioinformatics and experimental validation DOI Creative Commons
Pengfei Wen, Yan Zhao, Mingyi Yang

и другие.

Journal of Cellular and Molecular Medicine, Год журнала: 2024, Номер 28(14)

Опубликована: Июль 1, 2024

Abstract The pathogenesis of ankylosing spondylitis (AS) remains unclear, and while recent studies have implicated necroptosis in various autoimmune diseases, an investigation its relationship with AS has not been reported. In this study, we utilized the Gene Expression Omnibus database to compare gene expressions between patients healthy controls, identifying 18 differentially expressed necroptosis‐related genes (DENRGs), 8 upregulated 10 downregulated. Through application three machine learning algorithms—least absolute shrinkage selection operation, support vector machine‐recursive feature elimination random forest—two hub genes, FASLG TARDBP, were pinpointed. These demonstrated high specificity sensitivity for diagnosis, as evidenced by receiver operating characteristic curve analysis. findings further supported external datasets cellular experiments, which confirmed downregulation upregulation TARDBP patients. Immune cell infiltration analysis suggested that CD4 + T cells, CD8 NK cells neutrophils may be associated development AS. Notably, group expression, there was a significant memory‐activated resting relatively less memory‐resting neutrophils. Conversely, enhanced naïve M0 macrophages, reduced presence cells. summary, contribute regulating immune microenvironment immune‐related signalling pathways. offer new insights into molecular mechanisms suggest potential targets therapeutic strategies.

Язык: Английский

Процитировано

2
The mechanisms behind heatstroke-induced intestinal damage DOI Creative Commons
Meng Sun, Qin Li, Zhimin Zou

и другие.

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Окт. 28, 2024

Abstract With the frequent occurrence of heatwaves, heatstroke (HS) is expected to become one main causes global death. Being a multi-organized disease, HS can result in circulatory disturbance and systemic inflammatory response, with gastrointestinal tract being primary organs affected. Intestinal damage plays an initiating promoting role HS. Multiple pathways integrity intestinal epithelial barrier due heat stress hypoxia brought on by blood distribution. This usually leads leakage as well infiltration metastasis toxins pathogenic bacteria cavity, which will eventually cause inflammation whole body. A large number studies have shown that after involves body’s disruption oxidative balance, disorder tight junction proteins, massive cell death, microbial imbalance. Based these mechanisms, protecting regulating immune responses are effective treatment strategies. To better understand pathophysiology this complex process, review aims outline potential processes possible therapeutic strategies for recent years.

Язык: Английский

Процитировано

1