Cas no 5. Infection placentaire au SARS-CoV-2

Annales de Pathologie, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

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Deaths in children in England from SARS-CoV-2 infection during the first 2 years of the pandemic: a cohort study

BMJ Open, Год журнала: 2025, Номер 15(2), С. e092627 - e092627

Опубликована: Фев. 1, 2025

Objective The aim of this analysis was to describe the epidemiology, demographics and characteristics children young people (CYP) who died SARS-CoV-2 infection in England during first 2 years pandemic. Design cohort investigated study is all CYP, born alive at, or after, 22 weeks gestation, before their 18th birthday between 1 February 2020 31 March 2022 England. All cases were reviewed identify if probably, possibly, contributed death. Mortality rates calculated, assuming a Poisson distribution, for whole population, split by patient characteristics. Setting Participants 6389 CYP deaths reported National Child Database (NCMD). Main outcome Risk Results 88 identified as probably due COVID-19. Thus, COVID-19 responsible 1.4% 26-month period. Overall mortality rate 3.59 (2.88–4.42) per 000 person years, being highest youngest (< 5 years; 4.68 (3.16–6.68)) oldest (16/17 4.83 (2.57–8.26)) CYP. Asian Black had higher than those from white backgrounds (p<0.001), increased with increasing deprivation. majority (61/77, 79.2) COVID documented life limiting condition. Conclusions less old. Despite social changes, shielding vulnerable life-limiting (but not necessarily life-threatening) conditions, appeared have rates, similar that seen adults comparable underlying conditions. risk death more deprived neighbourhoods ethnic increased, explained other demographic

Язык: Английский

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COVID-19 Vaccination During Pregnancy and Major Structural Birth Defects

PEDIATRICS, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

BACKGROUND AND OBJECTIVES COVID-19 vaccination is recommended during pregnancy; however, evidence on the prevalence of major structural birth defects born to people vaccinated early in pregnancy (≤20 weeks gestation) limited. We compared by status and key strata: insurance provider, clinically diagnosed SARS-CoV-2 infection pregnancy, concomitant administration other maternal vaccines. also compared, head-to-head, brand (Moderna mRNA-1273 vs Pfizer-BioNTech BNT162b2). METHODS A claims-based cohort study captured pregnancies ending a live among with an estimated last menstrual period between August 15, 2021, December 24, 2021. Prevalence ratios comparing exposure vaccines were using binomial regression inverse probability treatment weights. RESULTS Among 78 052 pregnancies, we identified 1248 (1049 [160.6 per 10 000 births] unvaccinated 199 [156.4 people). No differences observed given (adjusted ratio [aPR], 0.96; 95% CI, 0.81–1.13). Findings unchanged (aPR, 1.02; 0.77–1.37). CONCLUSIONS not associated increased infants. These results support safety pregnancy.

Язык: Английский

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Factors influencing COVID-19 vaccination intentions and the moderating effect of perceived behavioral control among pregnant women: a cross-sectional study applying the revised Theory of Planned Behavior

Women s Health Nursing, Год журнала: 2025, Номер 31(1), С. 34 - 45

Опубликована: Март 28, 2025

Purpose: This study explored factors that influence coronavirus disease 2019 (COVID-19) vaccination intentions during pregnancy and examined the moderating effect of perceived behavioral control based on revised Theory Planned Behavior.Methods: cross-sectional online survey recruited 227 Korean pregnant women from an community. Data were collected December 2021 to January 2022 analyzed using independent t-test, analysis variance, Pearson correlation coefficients, multiple regression analysis. The PROCESS macro (model 1) simple slope used investigate behavior control.Results: Attitudes (β=.44, p<.001) subjective norms (β=.36, identified as influencing COVID-19 pregnancy. In final model, total explanatory power variables was 44% (F=90.47, p<.001). in relationship between attitudes intention not statistically significant (B=0.07, p=.382). However, it showed a (B=0.06, p=.046). For analysis, classified into three levels (low, moderate, high), analyzed. Pregnant with high level strongest (b=0.45, p<.001), indicating control.Conclusion: To increase among women, is imperative implement programs focus improving women’s attitudes, norms, toward vaccination, particular attention those low control.

Язык: Английский

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Comparing the maternal and neonatal outcomes in vaccinated and unvaccinated pregnant women against COVID-19: a retrospective cohort study

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Март 28, 2025

Following the emergence of COVID-19 disease, and considering limited number studies regarding vaccination among pregnant women, as well differences between vaccine administered in Iran those used other countries, this study aimed to compare maternal neonatal outcomes vaccinated unvaccinated women against disease. This retrospective cohort was conducted at comprehensive healthcare centers Rafsanjan city. Initially, contact information expectant mothers who were June 22, 2021, December obtained through Iran's integrated system (Sib). Subsequently, required collected via a checklist during phone interviews. Out 969 after applying inclusion exclusion criteria, 610 subjects included study. Among these, 330 unvaccinated, while remaining participants had received inactivated prior or pregnancy. Maternal compared women. Data analysis performed using SPSS version 26, employing one-way variance (ANOVA), Tukey's multiple comparison test, Fisher's exact Chi-square logistic regression. The findings indicated that significantly increased risk jaundice (P < 0.05). Conversely, miscarriage rate these lower No adverse observed including hypertensive disorders, gestational diabetes, hospitalization, infection, preterm labor, premature rupture membranes, perinatal mortality, admission intensive care unit, low birth weight. Vaccination is recommended for mitigate outcomes.

Язык: Английский

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mRNA SARS-CoV-2 Vaccination Before vs During Pregnancy and Omicron Infection Among Infants

JAMA Network Open, Год журнала: 2023, Номер 6(11), С. e2342475 - e2342475

Опубликована: Ноя. 10, 2023

Infants younger than 6 months are at risk of severe SARS-CoV-2 infection. Data lacking on the optimum timing for maternal vaccination and estimated effectiveness against Omicron variants, including XBB, infants.

Язык: Английский

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COVID-19 vaccination during pregnancy and adverse perinatal outcomes: a systematic review and meta-analysis

Transactions of the Royal Society of Tropical Medicine and Hygiene, Год журнала: 2024, Номер 118(7), С. 405 - 425

Опубликована: Янв. 31, 2024

Abstract We aimed to estimate the associations between coronavirus disease 2019 (COVID-19) vaccination during pregnancy and risks of adverse perinatal outcomes. performed a literature search in PubMed, Web Science Embase identify eligible studies published up 24 September 2023, yielding 39 included studies. Pooled relative (RRs) with 95% confidence intervals (CIs) were calculated random effects model. The pooled results showed that COVID-19 (any type or dose any trimester) was not associated an increased risk In particular, third trimester decreased preterm birth (&lt;37 weeks) (RR 0.85 [95% CI 0.74 0.98]), 5-min Apgar &lt;7 0.87 0.78 0.97]) neonatal intensive care unit (NICU) admission 0.90 0.86 0.95]). inverse also found analysis one-dose miscarriage 0.83 0.72 0.96]) 0.80 1.00]) two-dose NICU 0.76 0.96]). does increase negative outcomes for mother baby.

Язык: Английский

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Causes and Effects of COVID-19 Vaccine Hesitancy Among Pregnant Women and its Association with Adverse Maternal, Placental, and Perinatal Outcomes

The Yale Journal of Biology and Medicine, Год журнала: 2024, Номер 97(1), С. 73 - 84

Опубликована: Март 29, 2024

Populations identified to be severely affected by COVID-19, such as pregnant patients, require special consideration in vaccine counseling, access, and provider education. Maternal infection with COVID-19 poses a significant risk the maternal-fetal dyad known adverse placenta destruction [1-5]. Despite widespread access availability of vaccinations, hesitancy continues persist is highly prevalent populations [6-9]. Addressing multitude social ecological factors surrounding can aid providing holistic counseling [10]. However, are foremost shaped maternal concern over possible fetal effects from vaccination. While changes policy help foster acceptance, increasing global education incorporation motivational interviewing skills first steps towards acceptance.

Язык: Английский

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Striving for equitable vaccination coverage: Leveraging rapid coverage and community assessments during the COVID-19 pandemic to reach missed populations in Cambodia

Vaccine, Год журнала: 2024, Номер unknown

Опубликована: Июнь 1, 2024

Amid the global response to COVID-19 pandemic, Cambodia emerges as a notable exemplar, boasting remarkable vaccination rate of 91% its population by end 2021. This success can be attributed multifaceted approach encompassing strong governmental leadership, robust vaccine management, and effective risk communication. Despite success, challenges persisted in reaching unvaccinated segments population. Rapid Coverage Community assessments (RCCAs) supported UNICEF were deployed 2022 2023 support Government efforts expanding reach missed populations bolster booster doses. RCCAs conducted across 8 provinces, assessing 13,547 individuals from 87 low-coverage communes identify not vaccinated people understand their barriers. Overall, only seven percent any dose C-19 vaccine, Disabilities lack education correlated with higher rates zero doses (20.8% 17.8%, respectively), concerns about personal health conditions (25%) adverse effects (10%) cited top reasons for non-vaccination. RCCAs, differing routine monitoring, utilized purposive sampling barriers access uptake. Findings informed adaptive strategies government partners enhance outreach areas. The played crucial role at local level ensuring vaccinations reached overlooked populations, providing innovative solutions supporting UNICEF's national strategies. By 2022, achieved high subnational coverage, contributing coverage 95% primary nearly 70% first everyone above three years old. also fostered coordination, facilitating resource sharing, coordinated action more community trust. Integration into immunization programs is recommended develop targeted underserved including zero-dose children communities. Cambodia's adaptation during pandemic offers valuable insights identifying engaging highlighting importance involvement interventions future preparedness, achieving equitable outcomes longer-term.

Язык: Английский

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Maternal Vaccination in Pregnancy: An Assessment of Influenza, Pertussis, and COVID-19 Vaccination Rates in Cracow, Poland

Medical Science Monitor, Год журнала: 2024, Номер 30

Опубликована: Янв. 22, 2024

BACKGROUND:Maternal vaccination during pregnancy reduces the risk of severe course and complications from infections both for mother her child. As information regarding immunization status pregnant women with recommended vaccines in Poland is scarce, this questionnaire-based study aimed to identify influenza, pertussis (whooping cough), COVID-19 205 Cracow, Poland, between February April 2023. Another objective was assess whether any maternal factors might influence women's decision inoculate pregnancy. MATERIAL AND METHODS:An anonymous self-reported questionnaire developed specifically disseminated among postpartum women, who gave birth were hospitalized at Department Obstetrics Perinatology University Hospital Study participants asked about their basic sociodemographic obstetric data, as well pertussis, most recent RESULTS:Only 12.2% 23.4% received influenza vaccinations, respectively, pregnancy, while 61.5% reported least 2 doses mRNA vaccine. Features including type occupation, place residence, gravidity, parity statistically significant (P<0.05) influencing likelihood vaccination. CONCLUSIONS:Influenza coverage suboptimal lower than observed other countries, rates are on par global trends.

Язык: Английский

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