Current Green Chemistry,
Год журнала:
2023,
Номер
11(2), С. 127 - 147
Опубликована: Сен. 18, 2023
Abstract:
The
development
of
synthetic
methodologies
to
obtain
a
diverse
range
heterocyclic
scaffolds
has
been
very
attractive
area
research
due
their
vast
therapeutic
importance.
Conventional
approaches
that
require
the
use
organic
solvents,
which
are
generally
flammable,
toxic,
and
not
ecofriendly,
replaced
either
with
greener
alternatives
or
by
completely
avoiding
use.
In
literature,
several
solvent-free
methods
have
already
reported
for
synthesis
varieties
compounds.
This
review
focuses
on
developed
different
types
nitrogen
oxygen
heterocycles
exhibited
applications.
Advances in chemical and materials engineering book series,
Год журнала:
2025,
Номер
unknown, С. 435 - 494
Опубликована: Янв. 3, 2025
The
structural
resemblance
between
the
fused
imidazopyridine
heterocyclic
ring
system
(a
purine
system)
has
prompted
biological
investigations
to
assess
their
potential
therapeutic
significance.
They
are
known
play
a
crucial
role
in
numerous
disease
conditions.
In
recent
years,
new
preparative
methods
for
synthesis
of
imidazopyridines
using
various
catalysts
or
non-catalytic
systems
have
been
described.
present
chapter,
we
summarise
approaches
adopted
functionalized
imidazo-pyridines
over
last
two
decades
along
with
clinical
advancement
and
applications.
key
points
here
including,
traditional
cyclo-condensation,
reaction
nitro
olefins,
alkynes,
3-CCR
(3-Component
Condensation
Reaction)
based
MCRs
miscellaneous
aspects
imidazo-pyridine
its
importance
presented
discussed.
This
chapter
will
provide
initiatives
chemists
towards
possible
medicinal
applications
reported
methods.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Herein,
we
report
an
efficient
synthetic
protocol
for
the
Friedel–Crafts
reaction
of
imidazo[1,2-a]pyridines
with
propargyl
alcohols
in
HFIP.
Notably,
this
FC
allenylation
works
without
any
additional
solvent
or
catalyst
and
requires
neither
inert
conditions
nor
heating.
In
method,
HFIP,
besides
offering
hydrogen
bonding
alcohol,
also
stabilizes
resultant
carbocation,
thus
forming
product.
This
method
enables
straightforward
synthesis
1,3-enynes.
The
current
offers
a
large
substrate
diversity
good
to
excellent
yields.
We
demonstrated
gram-scale
modifications.
Abstract
Several
novel
imidazo[1,2‐
a
]pyridine‐isoquinoline‐linked
sulfonyl
derivatives
were
designed
and
synthesized
in
this
study.
These
subsequently
assessed
vitro
for
their
inhibitory
effects
on
EGFR
kinases
antiproliferative
activity
against
two
breast
cancer
cell
lines.
of
the
compounds
demonstrated
satisfactory
efficacy
comparison
to
primary
agent,
erlotinib.
The
most
promising
compounds,
6‐methoxy‐2‐methyl‐1‐(2‐phenyl‐6‐(1‐((3‐(trifluoromethyl)phenyl)sulfonyl)‐1,2,3,6‐tetrahydro
pyridin‐4‐yl)imidazo[1,2‐a]pyridin‐3‐yl)‐1,2,3,4‐tetrahydro
isoquinoline,
6‐methoxy‐2‐methyl‐1‐(2‐phenyl‐6‐(1‐((4‐(trifluoromethoxy)
phenyl)
sulfonyl)‐1,2,3,6‐tetrahydropyridin‐4‐yl)imidazo[1,2‐a]pyridin‐3‐yl)‐1,2,3,4‐tetrahydroisoquinoline,
6‐methoxy‐2‐methyl‐1‐(2‐phenyl‐6‐(1‐((3‐(trifluoromethoxy)phenyl)sulfonyl)‐1,2,3,6‐tetrahydropyridin‐4‐yl)
imidazo[1,2‐a]pyridin‐3‐yl)‐1,2,3,4‐tetrahydroisoquinoline,
exhibited
exceptional
anticancer
MCF‐7
MDA‐MB‐231
lines,
with
IC
50
values
ranging
from
2.69
±
0.24
7.64
0.15
µM.
Subsequently
results
that
above
potent
more
efficacious
than
conventional
medicine
molecular
interactions
human
epidermal
growth
factor
receptor
(EGFR)
(PDB:
4HJO),
which
included
co‐crystallized
ligand
(erlotinib)
evaluated
through
silico
docking
studies.
It
was
noted
binding
energies
all
higher
those
standard
drug,
Journal of Heterocyclic Chemistry,
Год журнала:
2022,
Номер
59(12), С. 2051 - 2075
Опубликована: Июль 7, 2022
Abstract
The
fascinating
molecular
structure
and
versatile
bioactivity
of
imidazo[1,2‐a]pyridine
scaffold
attracts
the
scientific
community
to
develop
new
based
antibacterial
agent
in
current
situation.
This
systematic
review
provides
a
deep
insight
into
recent
advances
derivatives
its
activities
from
2010
2021.
Moreover,
structure–activity
relationship
synthetic
approaches
are
also
cautiously
summarized
throughout
which
affords
clear
vision
for
medicinal
chemists
design
agents.
Green Chemistry,
Год журнала:
2023,
Номер
26(3), С. 1329 - 1337
Опубликована: Дек. 21, 2023
We
have
developed
a
protocol
for
the
regioselective
synthesis
of
substituted
imidazo[1,2-α]pyridines
at
room
temperature
using
low-energy
visible
light,
inexpensive
CuCl
as
catalyst,
readily
available
starting
materials,
mild
reaction
conditions,
and
O
2
green
oxidant.
Beilstein Journal of Organic Chemistry,
Год журнала:
2024,
Номер
20, С. 628 - 637
Опубликована: Март 19, 2024
The
imidazo[1,2-
a
]pyridine
moiety
is
present
in
drugs
with
several
biological
activities.
most
direct
way
of
obtaining
this
nucleus
the
Groebke–Blackburn–Bienaymé
three-component
reaction
(GBB-3CR)
between
aminopyridines,
aldehydes,
and
isocyanides
under
both
Lewis
Brønsted
acid
catalysis.
However,
catalysts
for
have
major
drawbacks
such
as
being
expensive,
extremely
dangerous,
strong
oxidizing,
even
explosive.
In
scenario,
heteropolyacids
emerge
greener
safer
alternatives
due
to
their
very
acidity.
particular,
phosphotungstic
(HPW)
an
economical
green
attractive
catalyst
cheap,
non-toxic,
known
its
chemical
thermal
stability.
Herein,
we
report
straightforward
approach
GBB-3CR
using
HPW
ethanol
microwave
(μw)
heating.
This
convenient
environmentally
benign
methodology
broad
scope,
provides
heterobicyclic
products
high
yields
(up
99%),
low
loading
(2
mol
%)
only
30
minutes,
allows
successful
use
aliphatic
substrates
not
so
frequently
explored
usual
reaction.
Furthermore,
aforementioned
advantages
make
superior
existing
ones.
