Recent Progress on Natural α-glucosidase Inhibitors Derived from the Plants and Microorganisms

Current Medicinal Chemistry, Год журнала: 2023, Номер 31

Опубликована: Ноя. 27, 2023

Abstract: α-Glucosidase inhibitors (AGIs) showcase versatile biochemical activities with respect to antidiabetic, anticancerous, antiobese and antiviral effects. They have drawn a great deal of attention from the scientific community. While α-glucosidase are mostly discovered plants microorganisms, recent advance in natural αglucosidase over past five years has been reviewed this article, 139 distinct microorganisms were classified into ten groups based on their chemical structures, including flavonoids (34), xanthones (6), alkaloids (8), benzopyrones / benzofuranones terpenes (23), saponins phenols alcohols (25), esters (18), chalcone (5) other compounds (4). In review, we mainly focused novel structures various biological theses AGIs. Some selected exhibit powerful inhibitory activity anti-tumor activity, may hold promise become candidate drugs for treating type II diabetes cancer future.

Язык: Английский

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Natural Products in Liver Fibrosis Management: A Five-year Review

Current Medicinal Chemistry, Год журнала: 2024, Номер 31(31), С. 5061 - 5082

Опубликована: Фев. 16, 2024

: Liver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting critical need for understanding molecular mechanisms fibrosis. This knowledge could not only aid in developing therapies but also enable early intervention, enhance disease prediction, and improve our interaction between various underlying conditions liver. Notably, natural products used traditional medicine systems worldwide demonstrating diverse biochemical pharmacological activities increasingly recognized their potential treating review aims to comprehensively understand emphasizing advancements exploring products' over past five years. It acknowledges challenges development seeks underscore potency enhancing patient prognosis reducing burden disease.

Язык: Английский

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Bioactivity of fluorophenyl thiourea derivatives: Antioxidant efficacy and inhibition of key diabetes‐related enzymes

Biotechnology and Applied Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Thiourea structures, known for their wide-ranging bioactivity, have significant potential in diabetes management. In this study, it was aimed to examine the antioxidant capacities of fluorophenyl thiourea derivative compounds and inhibition studies on α-amylase α-glycosidase enzyme activity. Antioxidant capacity determined using Fe

Язык: Английский

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Torachrysone-8-O-β-d-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products

Biochemical Pharmacology, Год журнала: 2023, Номер 218, С. 115931 - 115931

Опубликована: Ноя. 18, 2023

Язык: Английский

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