Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 218, P. 115931 - 115931
Published: Nov. 18, 2023
Language: Английский
BMC Complementary Medicine and Therapies, Journal Year: 2023, Volume and Issue: 23(1)
Published: July 5, 2023
Abstract Background Xuelian granule (XL), a traditional Chinese medicine (TCM) formula, has been used for the treatment of diabetic nephropathy long time as hospital preparation. Because active ingredients in XL that can help to treat are still unclear, which limits interpretation its pharmacological mechanism, further development and subsequent study on material basis efficacy. Methods In this study, screening method based inhibition activity against aldose reductase (AR) was employed activity-directed chemical analysis using ultra-high performance liquid chromatography combined with quadrupole-orbitrap high resolution mass spectrometry (UHPLC-Q-orbitrap-HRMS) technique. Results A total 178 compounds, including 46 terpenes, 47 organic acids, 25 flavonoids, 29 phenylethanoid glycosides, 31 other types, were tentatively identified from might responsible AR activity. Conclusion This is first systematic, rapid, accurate qualitative XL. research provides scientific experimental researches pharmacodynamics quality control
Language: Английский
Citations
2
Current Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 31
Published: Nov. 27, 2023
Abstract: α-Glucosidase inhibitors (AGIs) showcase versatile biochemical activities with respect to antidiabetic, anticancerous, antiobese and antiviral effects. They have drawn a great deal of attention from the scientific community. While α-glucosidase are mostly discovered plants microorganisms, recent advance in natural αglucosidase over past five years has been reviewed this article, 139 distinct microorganisms were classified into ten groups based on their chemical structures, including flavonoids (34), xanthones (6), alkaloids (8), benzopyrones / benzofuranones terpenes (23), saponins phenols alcohols (25), esters (18), chalcone (5) other compounds (4). In review, we mainly focused novel structures various biological theses AGIs. Some selected exhibit powerful inhibitory activity anti-tumor activity, may hold promise become candidate drugs for treating type II diabetes cancer future.
Language: Английский
Citations
2
Biotechnology and Applied Biochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Thiourea structures, known for their wide-ranging bioactivity, have significant potential in diabetes management. In this study, it was aimed to examine the antioxidant capacities of fluorophenyl thiourea derivative compounds and inhibition studies on α-amylase α-glycosidase enzyme activity. Antioxidant capacity determined using Fe
Language: Английский
Citations
0
Current Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 31(31), P. 5061 - 5082
Published: Feb. 16, 2024
: Liver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting critical need for understanding molecular mechanisms fibrosis. This knowledge could not only aid in developing therapies but also enable early intervention, enhance disease prediction, and improve our interaction between various underlying conditions liver. Notably, natural products used traditional medicine systems worldwide demonstrating diverse biochemical pharmacological activities increasingly recognized their potential treating review aims to comprehensively understand emphasizing advancements exploring products' over past five years. It acknowledges challenges development seeks underscore potency enhancing patient prognosis reducing burden disease.
Language: Английский
Citations
0
Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 218, P. 115931 - 115931
Published: Nov. 18, 2023
Language: Английский
Citations
0