Recent advances in the application of heterogeneous catalysts for the synthesis of benzimidazole derivatives

Coordination Chemistry Reviews, Год журнала: 2024, Номер 505, С. 215714 - 215714

Опубликована: Фев. 12, 2024

Язык: Английский

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Magnetic nanomaterials as green and recoverable nanocatalysts: Research on synthesis of benzimidazole derivatives

Synthetic Communications, Год журнала: 2024, Номер 54(9), С. 709 - 734

Опубликована: Март 28, 2024

Research on benzimidazole derivatives is always an attractive challenge among synthetic chemists because are very key and important components in the structure of many drugs, biological active molecules, natural products. Benzimidazole interesting their valuable medicinal activities, such as anti-bacterial, anti-cancer, anti-tuberculosis, anti-fungal, pain killer, anti-HIV activities. During last decade, most reports field catalysts have been related to magnetic nanocatalysts, which shows high popularity remarkable efficiency this type catalyst performing chemical reactions. Magnetic nanocatalysts ideal both from point view green chemistry economically they easily separated reaction mixture significant catalytic activity. In review article, we summarized methods presented synthesis various based use nanomaterials recoverable catalysts.

Язык: Английский

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Quantum Chemical Calculation, Molecular Docking, and Biological Activity Properties of Imidazole, Pyrimidine, and Diazepine Based Compounds

ChemistrySelect, Год журнала: 2025, Номер 10(11)

Опубликована: Март 1, 2025

Abstract In this study, seven known compounds ( 5a–g ) were tested towards four human cancer cell lines including DLD‐1, HepG2, MDA‐MB‐231, and MCF‐7 for 48 h. addition, all also in a normal line (Wl‐38). The results showed that compound 5e particular had cytotoxic effects MCF‐7. molecular modeled structures of investigated the ground state optimized using density functional theory (DFT). chemical parameters determined by DFT calculations. HOMOs LUMOs revealed to provide reasonable qualitative indication their excitation properties. To support experimental studies, 5a , 5c with anticancer interacted epidermal growth factor receptor (EGFR) vascular endothelial 2 (VEGFR‐2), which as possible targets. As result these interactions, binding parameter values (docking score, Glide e‐model, energy) between ligand target calculated.

Язык: Английский

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Zinc(II)‐Catalyzed Green Synthesis of 1H‐Benzo[d]imidazole Derivatives and Thiabendazole: An Efficient Approach

Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract A green protocol for the synthesis of 1 H ‐benzo[ d ]imidazole derivatives, utilizing zinc(II) catalysis in a one‐pot strategy is successfully developed. This method efficiently accomplishes reaction o ‐phenylenediamine with variety aldehydes, yielding benzimidazoles superior efficiency spanning broad substrate scope. An admirable application this Thiabendazole, an anthelmintic drug highlighting prominent achievement synthesis. Mild operational conditions and excellent yields make methodology highly sustainable.

Язык: Английский

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Spectroscopic characterization, DFT calculations, antimicrobial activity, and molecular docking studies of 5-methoxy-1H-benzo[d]imidazole and its Ag(I) complex

Polyhedron, Год журнала: 2024, Номер 251, С. 116868 - 116868

Опубликована: Янв. 26, 2024

Язык: Английский

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Recent developments of benzimidazole based analogs as potential tubulin polymerization inhibitors: A critical review

Bioorganic & Medicinal Chemistry Letters, Год журнала: 2025, Номер unknown, С. 130167 - 130167

Опубликована: Март 1, 2025

Язык: Английский

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Synthesis, Cytotoxic Activity, Antiquorum Sensing Effect, Docking and Md Simulation of Novel 1,3‐Disubstituted 2‐Mercapto‐1H‐Benzo[D]Imidazolium Chlorides

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(4)

Опубликована: Апрель 1, 2025

ABSTRACT A series of benzimidazolium chlorides ( 2a‐c ) and their corresponding 2‐mercapto derivatives 3a‐c were proficiently synthesized analyzed by NMR LC‐MS spectra. The in vitro cytotoxic assay demonstrated that some compounds active on the cancer cell lines. binding potential most three to topoisomerase II alpha (topo2α) was explored unveil possible mode action for activity. examined through molecular docking. stability compound‐enzyme complexes from docking investigated dynamics (MD) simulation. study revealed showed ability bind enzyme. However, strength weaker than standard drug, doxorubicin. MD simulation analysis 3a 3b gave relatively stable with enzyme thus they would remain inside pocket during period. Furthermore, pharmacokinetic properties computed silico . computation disclosed all exhibited drug‐like properties. It is worth mentioning them found be nontoxic. In furtherance, inhibitory effect quorum sensing system inspected using biomonitor strains Chromobacterium violaceum 026, Chromobacterium. VIR07 Pseudomonas aeruginosa PAO1. this regard, we focused appraisal virulence factors, including pyocyanin, elastase, biofilm formation are created P. PAO1 as source infectious diseases. As a result, it determined displayed statistically significant inhibition effects, highest activity observed elastase production an rate 84–86%.

Язык: Английский

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Diaryl-substituted benzimidazole derivatives as antiproliferative agents: Design, synthesis, in vitro activity, and SAR analysis

Journal of Molecular Structure, Год журнала: 2024, Номер 1308, С. 137960 - 137960

Опубликована: Март 16, 2024

Язык: Английский

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Investigation of the Cytotoxic Activity, DFT Calculation, and Docking Studies Newly Synthesized 1,3-Disubstituted Benzimidazolium Chlorides on Human Liver Cancer, Lung Cancer, and Normal Embryonic Kidney Cell Lines

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 741, С. 151024 - 151024

Опубликована: Ноя. 19, 2024

Язык: Английский

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Synthesis, Cytotoxic Activity, Docking and MD Simulation of N,N‐Disubstituted New Benzimidazolium Salts

ChemistrySelect, Год журнала: 2023, Номер 8(43)

Опубликована: Ноя. 14, 2023

Abstract Novel N , ‐disubstituted benzimidazolium salts were efficaciously synthesized in moderate to high yields and identified via 1 H NMR 13 C analyses. These compounds tested on human liver cancer, prostate normal embryonic kidney cell lines for 72 h. The results demonstrated that these had antiproliferative activity. In particular, it was found one of the compounds, 1‐(3‐chlorobenzyl)‐3‐(3‐methylbenzyl)‐1 ‐benzo[ d ]imidazol‐3‐ium chloride, showed very activity against cancer line IC 50 value this compound almost twice as low cisplatin. anticancer potential explored through computational methods support experimental study results. binding sulfotransferase 1A1 (SULT1A1) investigated molecular docking dynamics simulation. Their electrochemical properties computed density functional theory. exhibited 1‐(3‐methylbenzyl)‐3‐(4‐nitrobenzyl)‐1 chloride highest bind SULT1A1. formed a stable complex. Furthermore, theory 1‐(3‐chlorobenzyl)‐3‐(4‐fluorobenzyl)‐1 might have chemical stability.

Язык: Английский

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