Theranostics,
Год журнала:
2020,
Номер
10(4), С. 1923 - 1947
Опубликована: Янв. 1, 2020
The
continuous
or
real-time
tracking
of
biological
processes
using
biocompatible
contrast
agents
over
a
certain
period
time
is
vital
for
precise
diagnosis
and
treatment,
such
as
monitoring
tissue
regeneration
after
stem
cell
transplantation,
understanding
the
genesis,
development,
invasion
metastasis
cancer
so
on.
rationally
designed
nanoparticles,
including
aggregation-induced
emission
(AIE)
dots,
inorganic
quantum
dots
(QDs),
nanodiamonds,
superparamagnetic
iron
oxide
nanoparticles
(SPIONs),
semiconducting
polymer
(SPNs),
have
been
explored
to
meet
this
urgent
need.
In
review,
development
application
these
nanoparticle-based
trackers
variety
imaging
technologies,
fluorescence
imaging,
photoacoustic
magnetic
resonance
particle
positron
tomography
single
photon
computing
are
discussed
in
detail.
Moreover,
further
therapeutic
treatments
multi-functional
endowed
with
photodynamic
photothermal
modalities
also
introduced
provide
comprehensive
perspective
promising
research
field.
Accounts of Chemical Research,
Год журнала:
2022,
Номер
55(24), С. 3572 - 3580
Опубликована: Дек. 7, 2022
Relaxometry
is
a
technique
which
makes
use
of
specific
crystal
lattice
defect
in
diamond,
the
so-called
NV
center.
This
consists
nitrogen
atom,
replaces
carbon
atom
diamond
lattice,
and
an
adjacent
vacancy.
centers
allow
converting
magnetic
noise
into
optical
signals,
dramatically
increases
sensitivity
readout,
allowing
for
nanoscale
resolution.
Analogously
to
T1
measurements
conventional
resonance
imaging
(MRI),
relaxometry
allows
detection
different
concentrations
paramagnetic
species.
However,
since
very
local
measurements,
detected
signals
are
from
voxels
around
centers.
As
result,
it
possible
achieve
subcellular
resolutions
organelle
measurements.A
experiment
starts
with
polarizing
spins
using
strong
laser
pulse.
Afterward
switched
off
allowed
stochastically
decay
equilibrium
mix
states.
The
polarized
configuration
exhibits
stronger
fluorescence
than
state,
one
optically
monitor
this
transition
determine
its
rate.
process
happens
faster
at
higher
levels
noise.
Alternatively,
conduct
relaxation
dark
bright
by
applying
microwave
pulse
brings
-1
state
instead
0
state.
One
can
record
spectrum
varying
strengths
applied
field.
called
cross-relaxometry.
Apart
detecting
responsive
coatings
be
render
sensitive
other
parameters
as
pH,
temperature,
or
electric
Depending
on
application
there
three
ways
experiments:
moving
stationary
nanodiamonds,
scanning
magnetometry,
bulk
sample
top.In
Account,
we
present
examples
various
modes
well
their
advantages
limitations.
Due
simplicity
low
cost
approach,
has
been
implemented
many
instruments
wide
range
applications.
Herein
review
progress
that
achieved
physics,
chemistry,
biology.
Many
articles
field
have
proof-of-principle
character,
full
potential
technology
still
waits
unfolded.
With
would
like
stimulate
discourse
future
relaxometry.
Materials,
Год журнала:
2022,
Номер
16(1), С. 183 - 183
Опубликована: Дек. 25, 2022
To
fix
the
bone
in
orthopedics,
it
is
almost
always
necessary
to
use
implants.
Metals
provide
needed
physical
and
mechanical
properties
for
load-bearing
applications.
Although
widely
used
as
biomedical
materials
replacement
of
hard
tissue,
metallic
implants
still
confront
challenges,
among
which
foremost
their
low
biocompatibility.
Some
them
also
suffer
from
excessive
wear,
corrosion
resistance,
infections
shielding
stress.
address
these
issues,
various
coatings
have
been
applied
enhance
vitro
vivo
performance.
When
merged
with
beneficial
bio-ceramic
or
polymer
remarkable
bioactive,
osteogenic,
antibacterial,
biodegradable
composite
can
be
created.
In
this
review,
bioactive
high-performance
are
systematically
reviewed
biocompatibility
discussed.
Updates
coating
formulations
implants,
well
production
routes,
provided.
The
ways
improving
performance
by
incorporating
moieties
such
growth
factors,
osteogenic
immunomodulatory
antibiotics,
other
drugs
that
locally
released
a
controlled
manner
addressed.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(34), С. 39265 - 39273
Опубликована: Авг. 19, 2022
Here,
we
present
multifunctional
fluorescent
nanodiamonds
(FNDs)
for
simultaneous
drug
delivery
and
free
radical
detection.
For
this
purpose,
modified
FNDs
containing
nitrogen
vacancy
(NV)
centers
with
a
diazoxide
derivative.
We
found
that
our
particles
enter
cells
more
easily
are
able
to
deliver
cancer
into
HeLa
cells.
The
were
characterized
by
infrared
spectroscopy,
dynamic
light
scattering,
secondary
electron
microscopy.
Compared
the
drug,
observe
sustained
release
over
72
h
rather
than
12
drug.
Apart
from
releasing
these
particles,
can
measure
drug's
effect
on
generation
directly.
This
has
advantage
response
is
measured
locally,
where
released.
These
change
their
optical
properties
based
magnetic
surrounding.
More
specifically,
make
use
of
technique
called
relaxometry
detect
spin
noise
at
nanoscale
subcellular
resolution.
further
compared
results
new
conventional
fluorescence
assay
detection
reactive
oxygen
species.
provides
method
investigate
relationship
between
cell
via
formation
or
inhibition.
The Chemical Record,
Год журнала:
2024,
Номер
24(4)
Опубликована: Март 26, 2024
Nanodiamonds
(NDs)
have
garnered
attention
in
the
field
of
nanomedicine
due
to
their
unique
properties.
This
review
offers
a
comprehensive
overview
NDs
synthesis
methods,
properties,
and
uses
biomedical
applications.
Various
techniques,
such
as
detonation,
high-pressure,
high-temperature,
chemical
vapor
deposition,
offer
distinct
advantages
tailoring
NDs'
size,
shape,
surface
Surface
modification
methods
further
enhance
biocompatibility
enable
attachment
bioactive
molecules,
expanding
applicability
biological
systems.
serve
promising
nanocarriers
for
drug
delivery,
showcasing
ability
encapsulate
therapeutic
agents
targeted
delivery.
Additionally,
demonstrate
potential
cancer
treatment
through
hyperthermic
therapy
vaccine
enhancement
improved
immune
responses.
Functionalization
facilitates
utilization
biosensors
sensitive
biomolecule
detection,
aiding
precise
diagnostics
rapid
detection
infectious
diseases.
underscores
multifaceted
role
advancing
By
synthesizing
various
modifying
surfaces,
researchers
can
tailor
properties
specific
needs.
The
efficient
delivery
vehicles
holds
promise
therapy,
while
applications
innovative
approaches
immunization.
Furthermore,
integration
into
enhances
diagnostic
capabilities,
enabling
biomolecules
Overall,
diverse
functionalities
underscore
valuable
tools
nanomedicine,
paving
way
advancements
healthcare
biotechnology.
Theranostics,
Год журнала:
2020,
Номер
10(4), С. 1923 - 1947
Опубликована: Янв. 1, 2020
The
continuous
or
real-time
tracking
of
biological
processes
using
biocompatible
contrast
agents
over
a
certain
period
time
is
vital
for
precise
diagnosis
and
treatment,
such
as
monitoring
tissue
regeneration
after
stem
cell
transplantation,
understanding
the
genesis,
development,
invasion
metastasis
cancer
so
on.
rationally
designed
nanoparticles,
including
aggregation-induced
emission
(AIE)
dots,
inorganic
quantum
dots
(QDs),
nanodiamonds,
superparamagnetic
iron
oxide
nanoparticles
(SPIONs),
semiconducting
polymer
(SPNs),
have
been
explored
to
meet
this
urgent
need.
In
review,
development
application
these
nanoparticle-based
trackers
variety
imaging
technologies,
fluorescence
imaging,
photoacoustic
magnetic
resonance
particle
positron
tomography
single
photon
computing
are
discussed
in
detail.
Moreover,
further
therapeutic
treatments
multi-functional
endowed
with
photodynamic
photothermal
modalities
also
introduced
provide
comprehensive
perspective
promising
research
field.
