Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(6), С. 2475 - 2504
Опубликована: Март 20, 2024
Resistance
to
cancer
immunotherapy
is
mainly
attributed
poor
tumor
immunogenicity
as
well
the
immunosuppressive
microenvironment
(TME)
leading
failure
of
immune
response.
Numerous
therapeutic
strategies
including
chemotherapy,
radiotherapy,
photodynamic,
photothermal,
magnetic,
chemodynamic,
sonodynamic
and
oncolytic
therapy,
have
been
developed
induce
immunogenic
cell
death
(ICD)
cells
thereby
elicit
boost
antitumor
However,
many
challenges
hamper
clinical
application
ICD
inducers
resulting
in
modest
Here,
we
outline
current
state
using
nanomedicines
for
boosting
cells.
Moreover,
synergistic
approaches
used
combination
with
inducing
remodeling
TME
Abstract
Endogenous
essential
metal
ions
play
an
important
role
in
many
life
processes,
especially
tumor
development
and
immune
response.
The
approval
of
various
metallodrugs
for
therapy
brings
more
attention
to
the
antitumor
effect
ions.
With
deepening
understanding
regulation
mechanisms
ion
homeostasis
vivo,
breaking
intracellular
becomes
a
new
means
inhibit
proliferation
cells
activate
Diverse
nanomedicines
with
loading
small
molecular
regulators
or
have
been
developed
disrupt
cells,
higher
safety
efficiency
than
free
compounds.
This
comprehensive
review
focuses
on
latest
progress
regulation‐based
including
calcium
(Ca
2+
),
ferrous
(Fe
cuprous
(Cu
+
managanese
(Mn
zinc
(Zn
).
physiological
functions
processes
are
summarized
guide
design
nanomedicines.
Then
ions‐based
some
efficient
synergistic
therapies
highlighted.
Finally,
challenges
future
developments
also
discussed,
hoping
provide
reference
finding
effective
therapies.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 3, 2023
Immunotherapy
has
developed
rapidly
in
solid
tumors,
especially
the
areas
of
blocking
inhibitory
immune
checkpoints
and
adoptive
T-cell
transfer
for
regulation.
Many
patients
benefit
from
immunotherapy.
However,
response
rate
immunotherapy
overall
population
are
relatively
low,
which
depends
on
characteristics
tumor
individualized
patient
differences.
Moreover,
occurrence
drug
resistance
adverse
reactions
largely
limit
development
Recently,
emergence
nanodrug
delivery
systems
(NDDS)
seems
to
improve
efficacy
by
encapsulating
carriers
nanoparticles
precisely
reach
site
with
high
stability
biocompatibility,
prolonging
cycle
action
greatly
reducing
toxic
side
effects.
In
this
paper,
we
mainly
review
advantages
NDDS
mechanisms
that
enhance
conventional
summarize
recent
advances
NDDS-based
therapeutic
strategies,
will
provide
valuable
ideas
novel
regimen.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(6), С. 2475 - 2504
Опубликована: Март 20, 2024
Resistance
to
cancer
immunotherapy
is
mainly
attributed
poor
tumor
immunogenicity
as
well
the
immunosuppressive
microenvironment
(TME)
leading
failure
of
immune
response.
Numerous
therapeutic
strategies
including
chemotherapy,
radiotherapy,
photodynamic,
photothermal,
magnetic,
chemodynamic,
sonodynamic
and
oncolytic
therapy,
have
been
developed
induce
immunogenic
cell
death
(ICD)
cells
thereby
elicit
boost
antitumor
However,
many
challenges
hamper
clinical
application
ICD
inducers
resulting
in
modest
Here,
we
outline
current
state
using
nanomedicines
for
boosting
cells.
Moreover,
synergistic
approaches
used
combination
with
inducing
remodeling
TME
