Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 10, 2024
Traditional chemotherapeutic agents suffer from a lack of selectivity, poor targeting ability, and drug resistance. Developing tumor-specific therapies is crucial for precisely eliminating tumors while circumventing toxicity to normal tissues. Disulfiram (DSF), an FDA-approved treating alcohol dependence, exhibits antitumor effect by forming complexes with copper ions (Cu(DDC)
Язык: Английский
ACS Nano, Год журнала: 2024, Номер 18(15), С. 10495 - 10508
Опубликована: Апрель 1, 2024
Sonodynamic therapy (SDT) has promising application prospects in tumor therapy. However, SDT does not eradicate metastatic tumors. Herein, Cu-substituted ZnAl ternary layered double hydroxide nanosheets (ZCA NSs) were developed as both sonosensitizers and copper nanocarriers for synergistic SDT/cuproptosis cancer An optimized electronic structure more conducive to the sonodynamic process was obtained from ZCA NSs via Jahn–Teller effect induced by introduction of Cu2+, synthesized regulated intricate microenvironment (TME) depleting endogenous glutathione (GSH) amplify oxidative stress further enhanced performance. Furthermore, cuproptosis evoked intracellular overload Cu2+ amplified SDT, leading irreversible proteotoxicity. In vitro results showed that such synergetic triggered immunogenic cell death (ICD) promoted maturation dendritic cells (DCs). as-synthesized NS-mediated thoroughly eradicated vivo solid tumors simultaneously elicited antitumor immunity suppress lung liver metastasis. Overall, this work established a nanoplatform with satisfactory immunity.
Язык: Английский
Процитировано
41
Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(4)
Опубликована: Апрель 25, 2024
Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.
Язык: Английский
Процитировано
28
Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(7), С. 5813 - 5836
Опубликована: Март 22, 2024
Eight 2,2′:6′,2″-terpyridines, substituted at the 4′-position with aromatic groups featuring variations in π-conjugation, ring size, heteroatoms, and methoxy groups, were employed to enhance antiproliferative potential of [Cu2Cl2(R-terpy)2](PF6)2. Assessing cytotoxicity A2780 (ovarian carcinoma), HCT116 (colorectal HCT116DoxR carcinoma resistant doxorubicin) normal primary fibroblasts revealed that Cu(II) complexes 4-quinolinyl, 4-methoxy-1-naphthyl, 2-furanyl, 2-pyridynyl substituents showed superior therapeutic cells significantly reduced (42–129× lower). Besides their cytotoxicity, are able increase intracellular ROS interfere cell cycle progression, leading death by apoptosis autophagy. Importantly, they demonstrated antimetastatic antiangiogenic properties without vivo toxicity. In accordance nuclear accumulation, cleave pDNA interact bovine serum albumin, which is a good indication ability for internalization transport toward tumor cells.
Язык: Английский
Процитировано
14
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(6), С. 3673 - 3692
Опубликована: Май 8, 2024
Copper (Cu) and Cu-based nanomaterials have received tremendous attention in recent years because of their unique physicochemical properties good biocompatibility the treatment various diseases, especially cancer. To date, researchers designed fabricated a variety integrated nanocomplexes with distinctive nanostructures applied them cancer therapy, mainly including chemotherapy, radiotherapy (RT), photothermal therapy (PTT), chemodynamic (CDT), photodynamic (PDT), cuproptosis-mediated etc. Due to limited effect single method, development composite diagnostic nanosystems that integrate PTT, CDT, PDT, other treatments is great significance offers potential for next generation anticancer nanomedicines. In view rapid field this review focuses on current state research nanomaterials, followed by discussion combined therapy. Moreover, challenges future prospects clinical translation are proposed provide some insights into design nanotherapeutic platforms.
Язык: Английский
Процитировано
9
Applied Surface Science, Год журнала: 2024, Номер 670, С. 160642 - 160642
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
9
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101702 - 101702
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Май 5, 2025
Abstract The rapid deterioration and progression of hepatocellular carcinoma (HCC) is intimately associated with copper ion overload, integrating the cuproptosis mechanism for treatment HCC presents a promising prospect. Nevertheless, cell death complexity renders efficient removal all cells insufficient solely relying on pathway. Herein, GSH‐responsive prodrug hybridization nanoassembly CA‐4S 2 @ES‐Cu exploited, which targets delivery ions to mitochondria via Elesclomol, contributing mitochondrial dysfunction evoking cuproptosis. Simultaneously, depletes GSH release CA‐4, disrupting microtubule function suppressing proliferation angiogenesis, realize dual attack against ion‐mediated metastasis HCC. Furthermore, both in mouse model synergistically elicit oxidative stress amplify effect activated immunogenetic initiate vigorous antitumor immune response cascade assault modality. Conclusively, multilevel synergistic penetrates limitations single therapy implements multidimensional targeted
Язык: Английский
Процитировано
1
Coordination Chemistry Reviews, Год журнала: 2024, Номер 521, С. 216169 - 216169
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
8
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Фев. 19, 2024
The formation of blood vessel system under a relatively higher Cu
Язык: Английский
Процитировано
4
Analytical Letters, Год журнала: 2024, Номер unknown, С. 1 - 14
Опубликована: Март 1, 2024
Accurate detection of copper ions is crucial since it an essential trace element. Carbon quantum dots (CQDs) were prepared from apricot leaves using a hydrothermal method. These CQDs, which generated reference signal, combined with glutathione-bound gold nanoclusters (GSH-AuNCs) synthesized by the reduction chloroauric acid to form ratiometric fluorescent probe. The probe exhibited fluorescence emission at 450 nm and 568 nm. determination Cu(II) was performed through visual analysis color change intensity ratio (I450/I568) peaks. Orange GSH-AuNCs responded fluorescence, blue CQDs chemically inert. probes changed pink purple in response different concentrations Cu(II). linear range for 0 120 µmol/L, limit (LOD) 0.65 µmol/L. This study has demonstrated that provided good selectivity detecting water potential practical application.
Язык: Английский
Процитировано
4