Food Hydrocolloids, Год журнала: 2024, Номер 152, С. 109919 - 109919
Опубликована: Фев. 23, 2024
Язык: Английский
ACS Nano, Год журнала: 2024, Номер 18(11), С. 8143 - 8156
Опубликована: Март 4, 2024
The complexity and heterogeneity of individual tumors have hindered the efficacy existing therapeutic cancer vaccines, sparking intensive interest in development more effective situ vaccines. Herein, we introduce a nanovaccine for reactive oxygen species-augmented metalloimmunotherapy which FeAl-layered double hydroxide (LDH) is used as delivery vehicle with dihydroartemisinin (DHA) cargo. LDH framework acid-labile can be degraded tumor microenvironment, releasing iron ions, aluminum DHA. ions contribute to aggravated intratumoral oxidative stress injury by synergistic Fenton reaction DHA activation, causing apoptosis, ferroptosis, immunogenic cell death cells. subsequently released tumor-associated antigens adjuvant form generate robust long-term immune responses against recurrence metastasis. Moreover, Fe ion-enabled T1-weighted magnetic resonance imaging facilitate real-time therapy monitoring. This cancer-nanovaccine-mediated strategy has potential revolutionizing precision immunotherapy landscape.
Язык: Английский
Процитировано
11
The Chemical Record, Год журнала: 2024, Номер 24(4)
Опубликована: Март 19, 2024
Abstract Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist orthorhombic arrays metal with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced bioavailability, LDHs have many potential applications in medical field. Especially fields bioimaging tumor therapy. This paper reviews research progress nanocomposites field imaging First, structure advantages LDH discussed. Then, several commonly used methods for preparation presented, co‐precipitation, hydrothermal ion exchange methods. Subsequently, recent advances layered cancer therapy highlighted. Finally, based on current research, we summaries prospects challenges diagnosis
Язык: Английский
Процитировано
11
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Bacterial wound infections pose a significant threat to global health, exacerbated by the increase in multidrug-resistant bacteria (MDRB) and formation of elastic biofilms. This review explores transformative potential bioactive materials addressing these challenges, focusing on their design, mechanisms action, therapeutic effects. In vivo, are designed respond unique bacterial microenvironment (BME), utilizing enzyme activity, controlled gas release, surface functionalization, immune regulation combat infections. vitro, this provides comprehensive overview latest advances rational design materials, emphasizing synergistic integration structural modifications (such as size morphology) with external physical stimuli light, sound, electricity, magnetism, force) enhance antibacterial performance. Finally, outstanding challenges prospects rapidly evolving field discussed.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 237, С. 124177 - 124177
Опубликована: Март 25, 2023
Язык: Английский
Процитировано
22
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Янв. 3, 2023
Abstract Background Although the promising advancements of current therapeutic approaches is available for squamous cell carcinoma (SCC) patients, clinical treatment SCC still faces many difficulties. The surgical irreparable disfigurement and postoperative wound infection largely hamper recovery, chemo/radiotherapy leads to toxic side effects. Results Herein, a novel pH/Hyaluronidase (HAase) dual-stimuli triggered smart nanoprobe Fe III TA@HA has been designed through biomineralization 3+ polyphenol tannic acid (TA) under control hyaluronic (HA) matrix. With HA residues on outer surface, nanoprobes can specifically target cells over-expressed CD44, accumulate in region after intravenously administration. abundant HAase microenvironment will trigger degradation molecules, thereby exposing TA complex. After ingesting by tumor via CD44 mediated endocytosis, acidic lysosomal condition further protonation finally leading release nanoprobe, inducing hybrid ferroptosis/apoptosis peroxidase activity glutathione depletion. In addition, Owing outstanding T 1 magnetic resonance imaging (MRI) performance phototermal conversion efficiency nanoprobes, MRI-guided photothermal therapy (PTT) be also combined complement -induced cancer therapy. Meanwhile, it was found that promote recruitment CD4 + CD8 inhibit growth cytokines secretion. eliminated from body no obvious adverse effect histological analysis, which confirmed biosafety them. Conclusion huge potential translation field precise diagnosis intelligent synergistic superficial SCC. This strategy promisingly avoid defects, reduce systemic traditional chemotherapy, paving new way future treatment. Graphical
Язык: Английский
Процитировано
19
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(15), С. 18411 - 18421
Опубликована: Апрель 8, 2024
Cell necroptosis has presented great potential, acting as an effective approach against tumor apoptotic resistance, and it could be further enhanced via accompanying reactive oxygen species (ROS) overexpression. However, whether overproduced ROS assists the necroptotic pathway remains unclear. Thus, iron-palladium nanozyme (FePd NZ)- shikonin (SKN)-encapsulated functional lipid nanoparticles (FPS-LNPs) were designed to investigate overexpression-enhanced SKN-induced necroptosis. In this system, SKN acts inducer for cancer cells, FePd NZ, a sensitive Fenton reaction catalyst, produces extra-intracellular reinforce pathway. Both in vitro vivo antitumor evaluation revealed that FPS-LNPs best growth inhibition efficacy compared with FP-LNPs or SKN-LNPs alone. Meanwhile, induced by can trigger release of damage-associated molecular patterns (DAMPs) antigens from dying cells activate innate immune response. Taking biosafety into consideration, study provided potential nanoplatform nanotherapy inducing avoid apoptosis resistance CD8+ T cell
Язык: Английский
Процитировано
8
Advanced Functional Materials, Год журнала: 2024, Номер 34(18)
Опубликована: Янв. 14, 2024
Abstract Immunotherapy has significantly improved cancer treatment, yet the immunosuppressive tumor microenvironment (TME) remains a substantial impediment to therapeutic efficacy. Nanomodulators have emerged as promising tools address factors within TME, enhancing clinical interventions such immunotherapy, chemotherapy, and radiotherapy while minimizing associated safety risks with immune modulators. In this review, recent advancements are spotlighted in TME‐targeted nanomodulators from drug delivery drug‐free concepts. First, designed synergize various immunomodulatory agents, including gene (mRNA, siRNA, miRNA, plasmid DNA, CRISPER system), cytokines, agonists, inhibitors analyzed. Subsequently, recently developed modulate physicochemical biological properties of solid tumors succinctly presented. Finally, integrative perspectives on future development challenges assisting immunotherapy offered conclusions.
Язык: Английский
Процитировано
7
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(4), С. 2022 - 2040
Опубликована: Март 20, 2024
Chirality, one of the most fundamental properties natural molecules, plays a significant role in biochemical reactions. Nanomaterials with chiral characteristics have superior properties, such as catalytic optoelectronic and photothermal which potential for specific applications nanomedicine. Biomolecular modifications nucleic acids, peptides, proteins, polysaccharides are sources chirality nanomaterials great application addition to intrinsic chirality, artificial macromolecules, metals. Two-dimensional (2D) nanomaterials, opposed other dimensions, due proper surface area, extensive modification sites, drug loading potential, simplicity preparation, prepared utilized diagnostic applications, delivery research, tumor therapy. Current advanced studies on 2D biomedicine focused novel development, structural control, materials sustainability applications. However, despite advances biomedical still confront challenges difficulty synthesis, quality batch stability, recognition selectivity. This review aims provide comprehensive overview origins, biomolecules cargo highlight their roles biomedicine.
Язык: Английский
Процитировано
6
International Journal of Pharmaceutics, Год журнала: 2024, Номер 658, С. 124231 - 124231
Опубликована: Май 15, 2024
Язык: Английский
Процитировано
5