Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 28, 2024
Abstract
Doxorubicin
(DOX),
a
potent
antineoplastic
agent,
is
commonly
associated
with
cardiotoxicity,
necessitating
the
development
of
strategies
to
reduce
its
adverse
effects
on
cardiac
function.
Previous
research
has
demonstrated
strong
correlation
between
DOX‐induced
cardiotoxicity
and
activation
oxidative
stress
pathways.
This
work
introduces
novel
antioxidant
therapeutic
approach,
utilizing
libraries
tannic
acid
N‐acetyl‐L‐cysteine‐protected
bimetallic
cluster
nanozymes.
Through
extensive
screening
for
antioxidative
enzyme‐like
activity,
an
optimal
nanozyme
(AuRu)
identified
that
possess
remarkable
characteristics,
mimicking
catalase‐like
enzymes.
Theoretical
calculations
reveal
surface
interactions
prepared
nanozymes
simulate
hydrogen
peroxide
decomposition
process,
showing
these
readily
undergo
OH⁻
adsorption
O₂
desorption.
To
enhance
targeting,
atrial
natriuretic
peptide
conjugated
AuRu
nanozyme.
These
cardiac‐targeted
nanozymes,
their
anchoring
capability,
effectively
cardiomyocyte
ferroptosis
PANoptosis
without
compromising
tumor
treatment
efficacy.
Thus,
approach
demonstrates
significant
reductions
in
chemotherapy‐induced
cell
death
improvements
function,
accompanied
by
exceptional
vivo
biocompatibility
stability.
study
presents
promising
avenue
preventing
offering
potential
clinical
benefits
cancer
patients.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(33)
Опубликована: Апрель 21, 2023
Nanozymes,
nanomaterials
with
enzyme-mimicking
activity,
have
attracted
tremendous
interest
in
recent
years
owing
to
their
ability
replace
natural
enzymes
various
biomedical
applications,
such
as
biosensing,
therapeutics,
drug
delivery,
and
bioimaging.
In
particular,
the
nanozymes
capable
of
regulating
cellular
redox
status
by
mimicking
antioxidant
mammalian
cells
are
great
therapeutic
significance
oxidative-stress-mediated
disorders.
As
distinction
physiological
oxidative
stress
(oxidative
eustress)
pathological
distress)
occurs
at
a
fine
borderline,
it
is
challenge
design
that
can
differentially
sense
two
extremes
cells,
tissues
organs
mediate
appropriate
chemical
reactions.
this
Review,
we
summarize
advances
development
redox-active
applications.
We
primarily
highlight
prooxidant
disease
model
systems,
cancer,
neurodegeneration,
cardiovascular
diseases.
The
future
perspectives
emerging
area
research
challenges
associated
applications
described.
Abstract
Nanozymes
have
emerged
as
a
promising
alternative
to
natural
enzymes,
effectively
addressing
enzymes'
inherent
limitation.
Versatility
and
potential
applications
of
nanozyme
span
across
various
fields,
with
catalytic
tumor
therapy
being
one
prominent
area.
This
has
sparked
significant
interest
exploration
in
the
utilization
nanozymes
for
targeted
cancer
treatment.
Recent
advancements
interdisciplinary
research,
nanotechnology,
biotechnology,
technology
led
emergence
multi‐metallic‐based
nanozymes,
which
exhibit
tremendous
further
development.
review
focuses
on
investigating
synergistic
effects
aiming
enhance
our
understanding
their
activities
facilitate
broader
applications.
We
comprehensively
survey
remarkable
achievements
synthesis,
mechanisms,
latest
therapy.
Furthermore,
we
identify
current
limitations
prospects
development
new
materials
application
novel
technologies,
along
challenges
associated
underscores
significance
emphasizes
need
continued
well
impact
realization
breakthroughs
Abstract
Atherosclerosis,
a
multifaceted
chronic
inflammatory
disease,
has
profound
impact
on
cardiovascular
health.
However,
the
critical
limitations
of
atherosclerosis
management
include
delayed
detection
advanced
stages,
intricate
assessment
plaque
stability,
and
absence
efficacious
therapeutic
strategies.
Nanotheranostic
based
nanotechnology
offers
novel
paradigm
for
addressing
these
challenges
by
amalgamating
imaging
capabilities
with
targeted
interventions.
Meanwhile,
iron
oxide
nanoparticles
have
emerged
as
compelling
candidates
theranostic
applications
in
due
to
their
magnetic
resonance
capability
biosafety.
This
review
delineates
current
state
prospects
nanoparticle‐based
nanotheranostics
realm
atherosclerosis,
including
pivotal
aspects
development,
pertinent
targeting
strategies
involved
disease
pathogenesis,
diagnostic
roles
nanoparticles.
Furthermore,
this
provides
comprehensive
overview
nanomedicine
approaches
employing
nanoparticles,
encompassing
chemical
therapy,
physical
stimulation
biological
therapy.
Finally,
proposes
discusses
associated
translating
innovative
into
clinically
viable
anti‐atherosclerosis
In
conclusion,
new
insights
future
theranostic,
showcasing
remarkable
potential
oxide‐based
versatile
tools
battle
against
atherosclerosis.
Nano Letters,
Год журнала:
2023,
Номер
23(10), С. 4660 - 4668
Опубликована: Май 8, 2023
Oxidative
stress
is
known
to
be
the
cause
of
several
neurovascular
diseases,
including
neurodegenerative
disorders,
since
increase
reactive
oxygen
species
(ROS)
levels
can
lead
cellular
damage,
blood-brain
barrier
leaking,
and
inflammatory
pathways.
Herein,
we
demonstrate
therapeutic
potential
5
nm
platinum
nanoparticles
(PtNPs)
effectively
scavenge
ROS
in
different
models
unit.
We
investigated
mechanism
underlying
PtNP
biological
activities,
analyzing
influence
evolving
environment
during
particle
trafficking
disclosing
a
key
role
protein
corona,
which
elicited
an
effective
switch-off
catalytic
properties,
promoting
their
selective
