Nano Research, Год журнала: 2023, Номер 16(12), С. 13056 - 13076
Опубликована: Июль 15, 2023
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Май 6, 2024
Abstract Nanozyme, characterized by outstanding and inherent enzyme-mimicking properties, have emerged as highly promising alternatives to natural enzymes owning their exceptional attributes such regulation of oxidative stress, convenient storage, adjustable catalytic activities, remarkable stability, effortless scalability for large-scale production. Given the potent regulatory function nanozymes on stress coupled with fact that reactive oxygen species (ROS) play a vital role in occurrence exacerbation metabolic diseases, nanozyme offer unique perspective therapy through multifunctional achieving essential results treatment diseases directly scavenging excess ROS or regulating pathologically related molecules. The rational design strategies, nanozyme-enabled therapeutic mechanisms at cellular level, therapies several typical underlying are discussed, mainly including obesity, diabetes, cardiovascular disease, diabetic wound healing, others. Finally, pharmacokinetics, safety analysis, challenges, outlooks application also presented. This review will provide some instructive perspectives promote development strategies disease therapy. Graphical
Язык: Английский
Процитировано
16
Accounts of Materials Research, Год журнала: 2024, Номер 5(6), С. 687 - 698
Опубликована: Апрель 5, 2024
ConspectusNanomedicine is an interdisciplinary science that involves chemistry, materials, physics, engineering, biology, and medicine. The main focus of nanomedicine on drug carriers: how to improve efficacy reduce side effects. In order further the synergistic detoxifying effects nanomedicines, scientists have adopted a multifunctional integration strategy. However, versatility brings complex components ignores between components. lack in-depth research bioactivities nanocarriers hinders development clinical translation nanomedicine.In past decade, gradually discovered nanomaterials show excellent bioactivities, becoming enormous treasure trove for disease prevention treatment. Among numerous bioactive Prussian blue (PB) antidote approved by US Food Drug Administration, showing biosafety. clinically PB owns many drawbacks, it difficult satisfy requirements When size reduces nanoscale, nano shows both unique properties enhancement its performance bioactivities. Due easy-to-regulate structure rich iron suspended bonds, may be potential delivery system. Electron transition in Fe-CN-Fe endows with strong absorbance near-infrared region, photothermal conversion agent. Furthermore, due redox catalytic activities, great translational clinic prospect.In this Account, we describe our exploration as agent, system treatment over decade. We first summarize application agent cancer, then recent progress diseases (such tumors, neurodegeneration, cerebrovascular disease, bone-related degenerative gastrointestinal skin lesions). Finally, look forward open challenges future developments rapidly developing field. hope Account will help readers understand not only carrier but also drug, thus realizing These studies provide paradigm nanomaterials. As other teams continue explore promising material, characteristics represented bring exciting
Язык: Английский
Процитировано
15
ACS Nano, Год журнала: 2024, Номер 18(26), С. 16450 - 16467
Опубликована: Июнь 19, 2024
Nanozymes, which can selectively scavenge reactive oxygen species (ROS), have recently emerged as promising candidates for treating ischemic stroke and traumatic brain injury (TBI) in preclinical models. ROS overproduction during the early phase of these diseases leads to oxidative damage, has been a major cause mortality worldwide. However, clinical application ROS-scavenging enzymes is limited by their short vivo half-life inability cross blood-brain barrier. mimic catalytic function natural enzymes, several advantages, including cost-effectiveness, high stability, easy storage. These advantages render them superior disease diagnosis therapeutic interventions. This review highlights recent advancements nanozyme applications TBI, emphasizing potential mitigate detrimental effect overproduction, inflammation, barrier compromise. Therefore, nanozymes represent treatment modality conditions future medical practices.
Язык: Английский
Процитировано
15
Biomaterials Science, Год журнала: 2024, Номер 12(9), С. 2229 - 2243
Опубликована: Янв. 1, 2024
Nanozymes, a distinctive class of nanomaterials with enzyme-like activity and kinetics akin to enzyme-catalysed reactions, present several advantages over natural enzymes, including cost-effectiveness, heightened stability, adjustable activity.
Язык: Английский
Процитировано
14
Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 150047 - 150047
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
11
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 22, 2024
Conventional bone tissue engineering materials struggle to reinstate physiological remodeling in a diabetic context, primarily due the compromised repolarization of proinflammatory macrophages anti-inflammatory macrophages. Here, leveraging single-cell RNA sequencing (scRNA-seq) technology, pivotal role nitric oxide (NO) and reactive oxygen species (ROS) is unveiled impeding macrophage during amidst diabetes. Guided by scRNA-seq analysis, we engineer multienzymatic hydrogel scaffold (MEBTHS) composed engineered methylpropenylated gelatin integrated with ruthenium nanozymes, possessing both Ru
Язык: Английский
Процитировано
9
Acta Materia Medica, Год журнала: 2025, Номер 4(1)
Опубликована: Янв. 1, 2025
Cardiovascular diseases (CVDs) pose a significant threat to human health due the high mortality and morbidity rates. Traditional drugs often have limited efficacy inherent constraints, such as low bioavailability notable side effects. As highly regarded therapeutic strategy, nanotechnology offers new perspectives means for treating CVDs. Nanozyme-based targeted specifically address biological processes in areas affected by CVDs, thereby achieving precise treatment. Compared traditional drugs, nanozymes offer advantages, efficiency, specificity, controllability, fewer effects, showing great This paper first explores design strategies mechanisms of nanozyme-based therapy, then introduces its application key ischemic stroke, myocardial infarction, coronary heart disease. Finally, discusses challenges introducing into clinical applications future development prospects treatment
Язык: Английский
Процитировано
1
Analytica Chimica Acta, Год журнала: 2025, Номер unknown, С. 343716 - 343716
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Abstract Doxorubicin (DOX), a potent anthracycline chemotherapeutic agent, is widely used in cancer treatment but associated with significant adverse effects, particularly DOX‐induced cardiomyopathy (DIC). DIC pathogenesis involves the generation of reactive oxygen species (ROS) and ferroptosis induction. Novel therapeutic strategies targeting antioxidant defenses inhibition are essential for mitigating DIC. An innovative bimetallic metal‐organic framework (MOF), NiCu‐MOF (NCM), developed, exhibiting multifaceted enzyme‐mimicking activities that effectively scavenge broad spectrum ROS. Additionally, NCM exhibits excellent iron‐chelating ability. In vitro experiments demonstrate significantly reduces cardiomyocyte death by attenuating ROS levels inhibiting ferroptosis. Furthermore, mouse model DIC, results substantial myocardial protection, evidenced improved cardiac function structural integrity. This protective effect attributed to suppression ferroptosis, preservation mitochondrial function, attenuation inflammatory responses. Collectively, these findings highlight biocompatible NCM's potential as novel cardioprotective agent offer promising strategy managing
Язык: Английский
Процитировано
1
Materials Chemistry Frontiers, Год журнала: 2022, Номер 7(1), С. 44 - 64
Опубликована: Ноя. 22, 2022
The rapid advancement of nanomaterials has promoted the booming nanozymes capable mimicking natural enzymes.
Язык: Английский
Процитировано
31