Nanozyme as a rising star for metabolic disease management

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 6, 2024

Abstract Nanozyme, characterized by outstanding and inherent enzyme-mimicking properties, have emerged as highly promising alternatives to natural enzymes owning their exceptional attributes such regulation of oxidative stress, convenient storage, adjustable catalytic activities, remarkable stability, effortless scalability for large-scale production. Given the potent regulatory function nanozymes on stress coupled with fact that reactive oxygen species (ROS) play a vital role in occurrence exacerbation metabolic diseases, nanozyme offer unique perspective therapy through multifunctional achieving essential results treatment diseases directly scavenging excess ROS or regulating pathologically related molecules. The rational design strategies, nanozyme-enabled therapeutic mechanisms at cellular level, therapies several typical underlying are discussed, mainly including obesity, diabetes, cardiovascular disease, diabetic wound healing, others. Finally, pharmacokinetics, safety analysis, challenges, outlooks application also presented. This review will provide some instructive perspectives promote development strategies disease therapy. Graphical

Language: Английский

---

Prussian Blue Nanoparticle: From a Photothermal Conversion Agent and a Drug Delivery System, to a Bioactive Drug

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(6), P. 687 - 698

Published: April 5, 2024

ConspectusNanomedicine is an interdisciplinary science that involves chemistry, materials, physics, engineering, biology, and medicine. The main focus of nanomedicine on drug carriers: how to improve efficacy reduce side effects. In order further the synergistic detoxifying effects nanomedicines, scientists have adopted a multifunctional integration strategy. However, versatility brings complex components ignores between components. lack in-depth research bioactivities nanocarriers hinders development clinical translation nanomedicine.In past decade, gradually discovered nanomaterials show excellent bioactivities, becoming enormous treasure trove for disease prevention treatment. Among numerous bioactive Prussian blue (PB) antidote approved by US Food Drug Administration, showing biosafety. clinically PB owns many drawbacks, it difficult satisfy requirements When size reduces nanoscale, nano shows both unique properties enhancement its performance bioactivities. Due easy-to-regulate structure rich iron suspended bonds, may be potential delivery system. Electron transition in Fe-CN-Fe endows with strong absorbance near-infrared region, photothermal conversion agent. Furthermore, due redox catalytic activities, great translational clinic prospect.In this Account, we describe our exploration as agent, system treatment over decade. We first summarize application agent cancer, then recent progress diseases (such tumors, neurodegeneration, cerebrovascular disease, bone-related degenerative gastrointestinal skin lesions). Finally, look forward open challenges future developments rapidly developing field. hope Account will help readers understand not only carrier but also drug, thus realizing These studies provide paradigm nanomaterials. As other teams continue explore promising material, characteristics represented bring exciting

Language: Английский

---

Nanozymes: Potential Therapies for Reactive Oxygen Species Overproduction and Inflammation in Ischemic Stroke and Traumatic Brain Injury

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16450 - 16467

Published: June 19, 2024

Nanozymes, which can selectively scavenge reactive oxygen species (ROS), have recently emerged as promising candidates for treating ischemic stroke and traumatic brain injury (TBI) in preclinical models. ROS overproduction during the early phase of these diseases leads to oxidative damage, has been a major cause mortality worldwide. However, clinical application ROS-scavenging enzymes is limited by their short vivo half-life inability cross blood-brain barrier. mimic catalytic function natural enzymes, several advantages, including cost-effectiveness, high stability, easy storage. These advantages render them superior disease diagnosis therapeutic interventions. This review highlights recent advancements nanozyme applications TBI, emphasizing potential mitigate detrimental effect overproduction, inflammation, barrier compromise. Therefore, nanozymes represent treatment modality conditions future medical practices.

Language: Английский

---

Machine learning in nanozymes: from design to application

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(9), P. 2229 - 2243

Published: Jan. 1, 2024

Nanozymes, a distinctive class of nanomaterials with enzyme-like activity and kinetics akin to enzyme-catalysed reactions, present several advantages over natural enzymes, including cost-effectiveness, heightened stability, adjustable activity.

Language: Английский

---

Nb2CTx MXene coating with inhibition of oxidative stress prepared by Marangoni effect for hemodialysis therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 150047 - 150047

Published: Feb. 27, 2024

Language: Английский

---

Targeted nanozyme-enabled treatment of cardiovascular diseases

Acta Materia Medica, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 1, 2025

Cardiovascular diseases (CVDs) pose a significant threat to human health due the high mortality and morbidity rates. Traditional drugs often have limited efficacy inherent constraints, such as low bioavailability notable side effects. As highly regarded therapeutic strategy, nanotechnology offers new perspectives means for treating CVDs. Nanozyme-based targeted specifically address biological processes in areas affected by CVDs, thereby achieving precise treatment. Compared traditional drugs, nanozymes offer advantages, efficiency, specificity, controllability, fewer effects, showing great This paper first explores design strategies mechanisms of nanozyme-based therapy, then introduces its application key ischemic stroke, myocardial infarction, coronary heart disease. Finally, discusses challenges introducing into clinical applications future development prospects treatment

Language: Английский

---

Breakthroughs in nanozyme-inspired application diversity

Materials Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 7(1), P. 44 - 64

Published: Nov. 22, 2022

The rapid advancement of nanomaterials has promoted the booming nanozymes capable mimicking natural enzymes.

Language: Английский

---

The applications of nanozymes in neurological diseases: From mechanism to design

Theranostics, Journal Year: 2023, Volume and Issue: 13(8), P. 2492 - 2514

Published: Jan. 1, 2023

Nanozymes are a class of nanomaterials with enzyme-like catalytic activities.Due to their multiple activities, as well good stability, modifiable activity and other advantages over natural enzymes, they have wide range application prospects in sterilization, the treatment inflammation, cancer, neurological diseases, fields.In recent years, it has been found that various nanozymes antioxidant activity, allowing them simulate endogenous system play an important role cell protection.Therefore, can be applied reactive oxygen species (ROS)-related diseases.Another advantage is customized modified variety ways increase beyond classical enzymes.In addition, some unique properties, such ability effectively penetrate blood-brain barrier (BBB) or depolymerize otherwise eliminate misfolded proteins, making potentially useful therapeutic tools for diseases.Here, we review mechanisms antioxidant-like nanozymes, latest research progress strategies designing aiming promote development more effective diseases future.

Language: Английский

---

Platinum Nanozymes Counteract Photoreceptor Degeneration and Retina Inflammation in a Light-Damage Model of Age-Related Macular Degeneration

ACS Nano, Journal Year: 2023, Volume and Issue: 17(22), P. 22800 - 22820

Published: Nov. 7, 2023

Degeneration of photoreceptors in age-related macular degeneration (AMD) is associated with oxidative stress due to the intense aerobic metabolism rods and cones that if not properly counterbalanced by endogenous antioxidant mechanisms can precipitate photoreceptor degeneration. In spite being a priority eye disease for its high incidence elderly, no effective treatments AMD exist. While systemic administration antioxidants has been unsuccessful slowing down degeneration, locally administered rare-earth nanoparticles were shown be preventing retinal photo-oxidative damage. However, because inherent problems dispersion biological media, limited power, short lifetimes, these NPs are still confined preclinical stage. Here we propose platinum (PtNPs), potent nanozymes, as therapeutic tool AMD. PtNPs exhibit catalytic activity at minimal concentrations protect primary neurons against insults ensuing apoptosis. We tested efficacy intravitreally injected or mitigating light damage produced dark-reared albino Sprague–Dawley rats vivo electroretinography (ERG) ex retina morphology electrophysiology. found both preventive postlesional increased amplitude ERG responses stimuli. Ex recordings demonstrated selective preservation ON ganglion cell stimulation lesioned retinas treated PtNPs. after significantly preserved number inhibited inflammatory response while treatment had milder effect. The data indicate effectively break vicious cycle linking stress, inflammation exerting anti-inflammatory actions. survival visual performances degenerated retinas, together their biocompatibility, make potential strategy cure

Language: Английский

---

Reduction of Reactive Oxygen Species Accumulation Using Gadolinium-Doped Ceria for the Alleviation of Atherosclerosis

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(8), P. 10414 - 10425

Published: Feb. 20, 2023

Atherosclerosis is a common cardiovascular disease with increasing morbidity and mortality. The pathogenesis of atherosclerosis strongly related to endothelial dysfunction, which induced by severe oxidative stress damage derived from reactive oxygen species (ROS). Thus, ROS plays critical role in the progression atherosclerosis. In this work, we demonstrated that gadolinium doping CeO2 (Gd/CeO2) nanozymes as effective scavengers delivered high performance for antiatherosclerosis. It was found chemical Gd promoted surface proportion Ce3+ thereby enhanced overall scavenging ability. vitro vivo experiments unambiguously showed Gd/CeO2 efficiently scavenged harmful at cellular histological levels. Further, were significantly reduce vascular lesions reducing lipid accumulation macrophage decreasing inflammatory factor levels, inhibiting exacerbation Moreover, can serve T1-weighted magnetic resonance imaging contrast agents, generate sufficient distinguish location plaque during living imaging. Through those efforts, may potential diagnostic treatment nanomedicine ROS-induced

Language: Английский

---