Nanozyme-based biosensor for organophosphorus pesticide monitoring: Functional design, biosensing strategy, and detection application

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 165, С. 117152 - 117152

Опубликована: Июнь 20, 2023

Язык: Английский

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Research progress of nanozymes in colorimetric biosensing: Classification, activity and application

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150612 - 150612

Опубликована: Март 21, 2024

Язык: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

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Recent advances in multi‐metallic‐based nanozymes for enhanced catalytic cancer therapy

BMEMat, Год журнала: 2023, Номер unknown

Опубликована: Сен. 19, 2023

Abstract Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest exploration in the utilization nanozymes for targeted cancer treatment. Recent advancements interdisciplinary research, nanotechnology, biotechnology, technology led emergence multi‐metallic‐based nanozymes, which exhibit tremendous further development. review focuses on investigating synergistic effects aiming enhance our understanding their activities facilitate broader applications. We comprehensively survey remarkable achievements synthesis, mechanisms, latest therapy. Furthermore, we identify current limitations prospects development new materials application novel technologies, along challenges associated underscores significance emphasizes need continued well impact realization breakthroughs

Язык: Английский

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Unveiling the Glucose Oxidase‐Like and Catalase‐Like Activities of Highly Conjugated 3,4,9,10‐Perylenetetracarboxylic Dianhydride for Boosting Biofuel Cells

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Март 29, 2024

Abstract Carbon‐based nanozymes have received considerable attention due to their superior biosafety, enhanced tolerance extreme conditions, and ease of chemical modification. However, limited material diversity unconfirmed molecular structure, carbon‐based face challenges such as relatively low enzyme activity unclear catalytic mechanisms. The development materials with well‐defined structures controllable properties is crucial for promoting the rapid progress nanozymes. Herein, 3,4,9,10‐perylenetetracarboxylic dianhydride (PD) exhibits both glucose oxidase (GOx)‐like catalase (CAT)‐like activities, which may be fact that PD possesses features highly conjugated structure high electron mobility. In addition, it demonstrated enzymatic related degree aggregation via characterization its morphology size. Based on excellent GOx‐like CAT‐like activities PD, a self‐cascade system constructed application in biofuel cells (BFCs). It worth mentioning BFC still maintains stability after working 30 days. Therefore, this study expands enzyme‐like systems discovers nanomaterials mobility can mimic enzymes. Additionally, multi‐enzyme are utilized construct systems, effectively improve performance BFCs.

Язык: Английский

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Язык: Английский

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Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(13), С. 16011 - 16028

Опубликована: Март 26, 2024

Superbug infections and transmission have become major challenges in the contemporary medical field. The development of novel antibacterial strategies to efficiently treat bacterial conquer problem antimicrobial resistance (AMR) is extremely important. In this paper, a bimetallic CuCo-doped nitrogen–carbon nanozyme-functionalized hydrogel (CuCo/NC-HG) has been successfully constructed. It exhibits photoresponsive-enhanced enzymatic effects under near-infrared (NIR) irradiation (808 nm) with strong peroxidase (POD)-like oxidase (OXD)-like activities. Upon NIR irradiation, CuCo/NC-HG possesses photodynamic activity for producing singlet oxygen(1O2), it also high photothermal conversion effect, which not only facilitates elimination bacteria but improves efficiency reactive oxygen species (ROS) production accelerates consumption GSH. shows lower hemolytic rate better cytocompatibility than CuCo/NC positive charge macroporous skeleton restricting negatively charged range ROS destruction, strengthening efficiency. Comparatively, stronger bactericidal ability against methicillin-resistant Staphylococcus aureus (MRSA) ampicillin-resistant Escherichia coli (AmprE. coli) through destroying cell membranes negligible occurrence AMR. More importantly, plus can exhibit satisfactory performance absence H2O2, avoiding toxicity from high-concentration H2O2. vivo evaluation conducted using mouse wound infection model histological analyses, results show that upon suppress promote healing, without causing inflammation tissue adhesions.

Язык: Английский

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

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New horizons for the therapeutic application of nanozymes in cancer treatment

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Язык: Английский

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A Versatile PdRu Bimetallic Nanoenzyme-Integrated Enzyme-Linked Immunosorbent Assay for Highly Sensitive Escherichia coli O157:H7 Detection

Analytical Chemistry, Год журнала: 2023, Номер 95(24), С. 9237 - 9243

Опубликована: Май 26, 2023

Nanozymes have drawn much attention as an enzyme mimetic with low cost and stability in enhancing analytical performance. Herein, a peroxidase-mimicking nanozyme-improved enzyme-linked immunosorbent assay (ELISA) was developed employing the bimetallic PdRu nanozyme to replace natural enzymes catalytic carrier for sensing of Escherichia coli O157:H7 (E. O157:H7). The displayed ultrahigh activity, possessing rate that 5-fold higher than horseradish peroxidase (HRP). In addition, exhibited great biological affinity antibody (affinity constant about 6.75 × 1012 M) high stability. All those advantages ensure successful establishment construction novel colorimetric biosensor E. detection. PdRu-based ELISA not only achieved ultrasensitive detection sensitivity (8.7 102 CFU/mL) by approximately 288-fold compared traditional HRP-based also possessed satisfactory specificity reproducibility (relative standard deviation (RSD) < 10%). Furthermore, feasibility PdRu-ELISA further evaluated detecting actual samples recoveries, indicating its potential applications bioassays clinical diagnostics.

Язык: Английский

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