International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(12), С. 9882 - 9882
Опубликована: Июнь 8, 2023
Skin
interstitial
fluid
(ISF)
has
emerged
as
a
fungible
biofluid
sample
for
blood
serum
and
plasma
disease
diagnosis
therapy.
The
sampling
of
skin
ISF
is
highly
desirable
considering
its
easy
accessibility,
no
damage
to
vessels,
reduced
risk
infection.
Particularly,
can
be
sampled
using
microneedle
(MN)-based
platforms
in
the
tissues,
which
exhibit
multiple
advantages
including
minimal
invasion
less
pain,
ease
carrying,
capacity
continuous
monitoring,
etc.
In
this
review,
we
focus
on
current
development
microneedle-integrated
transdermal
sensors
collecting
detecting
specific
biomarkers.
Firstly,
discussed
classified
microneedles
according
their
structural
design,
solid
MNs,
hollow
porous
coated
MNs.
Subsequently,
elaborate
construction
MN-integrated
metabolic
analysis
with
highlights
electrochemical,
fluorescent,
chemical
chromogenic,
immunodiagnostic,
molecular
diagnostic
sensors.
Finally,
discuss
challenges
future
direction
developing
MN-based
extraction
sensing
applications.
Journal of Materials Chemistry A,
Год журнала:
2024,
Номер
12(9), С. 5348 - 5356
Опубликована: Янв. 1, 2024
A
porous
hydrogel
was
constructed
through
polymerization-induced
phase
separation
and
DLP
3D
printing.
After
in
situ
formation
of
an
interconnected
polypyrrole
network,
the
hybrid
shows
exceptional
electrical
conductivity
264
S
m
−1
.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(11), С. 1559 - 1572
Опубликована: Май 9, 2024
Three-Dimensional
(3D)
microneedles
have
recently
gained
significant
attention
due
to
their
versatility,
biocompatibility,
enhanced
permeation,
and
predictable
behavior.
The
incorporation
of
biological
agents
into
these
3D
constructs
has
advanced
the
traditional
microneedle
an
effective
platform
for
wide-ranging
applications.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(12)
Опубликована: Дек. 10, 2023
Abstract
Postoperative
pain,
as
a
common
and
significant
healthcare
issue,
has
always
been
the
focus
of
attention
in
field
anesthesia
for
its
control
treatment.
In
present
study,
pH‐responsive
microneedle
(MN)
patch
is
developed
sustained
incisional
analgesia
after
surgery.
The
MN
10
×
array
within
0.5
cm
2
area,
each
features
complete
core‐shell
structure,
with
needle
height
≈850
µm.
Upon
application,
MNs
fully
implant
skin
15
min
due
to
rapid
dissolution
water‐soluble
backing
layer.
acidic
microenvironment
at
surgical
site
(pH
6.8–7.0)
interacts
pH‐reactive
medium
shell,
triggering
shell
rupture.
This
process
enables
smooth
release
encapsulated
local
anesthetic
drug
(Ropivacaine,
Rop)
microcrystals,
extending
duration
over
72
h
concentration
100
mg
mL
−1
.
Additionally,
intelligently
modulates
based
on
postoperative
pain
behavior,
which
correlates
pH
value
incision
microenvironment.
responsive
feature
results
prolonged
personalized
analgesic
effect,
addressing
limitations
existing
invasive
treatments
management.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(12), С. 9882 - 9882
Опубликована: Июнь 8, 2023
Skin
interstitial
fluid
(ISF)
has
emerged
as
a
fungible
biofluid
sample
for
blood
serum
and
plasma
disease
diagnosis
therapy.
The
sampling
of
skin
ISF
is
highly
desirable
considering
its
easy
accessibility,
no
damage
to
vessels,
reduced
risk
infection.
Particularly,
can
be
sampled
using
microneedle
(MN)-based
platforms
in
the
tissues,
which
exhibit
multiple
advantages
including
minimal
invasion
less
pain,
ease
carrying,
capacity
continuous
monitoring,
etc.
In
this
review,
we
focus
on
current
development
microneedle-integrated
transdermal
sensors
collecting
detecting
specific
biomarkers.
Firstly,
discussed
classified
microneedles
according
their
structural
design,
solid
MNs,
hollow
porous
coated
MNs.
Subsequently,
elaborate
construction
MN-integrated
metabolic
analysis
with
highlights
electrochemical,
fluorescent,
chemical
chromogenic,
immunodiagnostic,
molecular
diagnostic
sensors.
Finally,
discuss
challenges
future
direction
developing
MN-based
extraction
sensing
applications.
