Bioprinting, Journal Year: 2024, Volume and Issue: 40, P. e00343 - e00343
Published: April 26, 2024
Language: Английский
Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(11), P. 1559 - 1572
Published: May 9, 2024
Three-Dimensional (3D) microneedles have recently gained significant attention due to their versatility, biocompatibility, enhanced permeation, and predictable behavior. The incorporation of biological agents into these 3D constructs has advanced the traditional microneedle an effective platform for wide-ranging applications.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 9882 - 9882
Published: June 8, 2023
Skin interstitial fluid (ISF) has emerged as a fungible biofluid sample for blood serum and plasma disease diagnosis therapy. The sampling of skin ISF is highly desirable considering its easy accessibility, no damage to vessels, reduced risk infection. Particularly, can be sampled using microneedle (MN)-based platforms in the tissues, which exhibit multiple advantages including minimal invasion less pain, ease carrying, capacity continuous monitoring, etc. In this review, we focus on current development microneedle-integrated transdermal sensors collecting detecting specific biomarkers. Firstly, discussed classified microneedles according their structural design, solid MNs, hollow porous coated MNs. Subsequently, elaborate construction MN-integrated metabolic analysis with highlights electrochemical, fluorescent, chemical chromogenic, immunodiagnostic, molecular diagnostic sensors. Finally, discuss challenges future direction developing MN-based extraction sensing applications.
Language: Английский
Citations
16
Small, Journal Year: 2023, Volume and Issue: 19(26)
Published: March 22, 2023
This work reports a portable, origami-type paper device with plasmonic fluor-labeled microneedle sensing module for the multiplexed quantification of anemia biomarkers in whole blood. Sequential steps, including serum separation, target enrichment, and readout by gel imager, are rapidly accomplished flexible highly integrated device. The array enabled efficient sampling trace targets from ng mL-1 to pg level. Combined fluor label, signal is improved ≈7.6 folds compared flat substrate-based assay. applied simultaneously quantify hemoglobin (Hb), ferritin, folic acid (FA), vitamin B12 (VB12 ), which four distributed different environments concentration ranges. Featured small sample volume (150 µL), short assay time (20 min), low cost (2 $), robust stability, user-friendliness, promising rapid accurate diagnosis real practice.
Language: Английский
Citations
14
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(12)
Published: Dec. 10, 2023
Abstract Postoperative pain, as a common and significant healthcare issue, has always been the focus of attention in field anesthesia for its control treatment. In present study, pH‐responsive microneedle (MN) patch is developed sustained incisional analgesia after surgery. The MN 10 × array within 0.5 cm 2 area, each features complete core‐shell structure, with needle height ≈850 µm. Upon application, MNs fully implant skin 15 min due to rapid dissolution water‐soluble backing layer. acidic microenvironment at surgical site (pH 6.8–7.0) interacts pH‐reactive medium shell, triggering shell rupture. This process enables smooth release encapsulated local anesthetic drug (Ropivacaine, Rop) microcrystals, extending duration over 72 h concentration 100 mg mL −1 . Additionally, intelligently modulates based on postoperative pain behavior, which correlates pH value incision microenvironment. responsive feature results prolonged personalized analgesic effect, addressing limitations existing invasive treatments management.
Language: Английский
Citations
14
Bioprinting, Journal Year: 2024, Volume and Issue: 40, P. e00343 - e00343
Published: April 26, 2024
Language: Английский
Citations
5