Radiation-activated PD-L1 aptamer-functionalized nanoradiosensitizer to potentiate antitumor immunity in combined radioimmunotherapy and photothermal therapy DOI
Bo Zhi Chen,

Yinbo He,

Long Bai

и другие.

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(47), С. 12220 - 12231

Опубликована: Янв. 1, 2024

This gold–MnO 2 nanoradiosensitizer enhances radioimmunotherapy by boosting ROS production, triggering immunogenic cell death, and effectively suppressing tumor growth metastasis.

Язык: Английский

The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions DOI Open Access
Guang Lei, Li Zhuang, Boyi Gan

и другие.

Cancer Cell, Год журнала: 2024, Номер 42(4), С. 513 - 534

Опубликована: Апрель 1, 2024

Язык: Английский

Процитировано

137

Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine DOI
Yanhong Su, Bing Liu, Binghan Wang

и другие.

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 14, 2024

Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.

Язык: Английский

Процитировано

20

A Multifunctional Covalent Organic Framework Nanozyme for Promoting Ferroptotic Radiotherapy against Esophageal Cancer DOI
Lele Zhou, Qun Guan, Wei Zhou

и другие.

ACS Nano, Год журнала: 2023, Номер 17(20), С. 20445 - 20461

Опубликована: Окт. 6, 2023

Radiotherapy is inevitably accompanied by some degree of radiation resistance, which leads to local recurrence and even therapeutic failure. To overcome this limitation, herein, we report the room-temperature synthesis an iodine- ferrocene-loaded covalent organic framework (COF) nanozyme, termed TADI-COF-Fc, for enhancement radiotherapeutic efficacy in treatment radioresistant esophageal cancer. The iodine atoms on COF not only exerted a direct effect radiotherapy, increasing its X-ray absorption, but also promoted radiolysis water, increased production reactive oxygen species (ROS). In addition, ferrocene surface decoration disrupted redox homeostasis levels hydroxyl lipid peroxide radicals depleting intracellular antioxidants. Both vitro vivo experiments substantiated excellent response TADI-COF-Fc. This study demonstrates potential COF-based multinanozymes as radiosensitizers suggests possible integration strategy combination oncotherapy.

Язык: Английский

Процитировано

37

Targeting Nrf2 for ferroptosis-based therapy: Implications for overcoming ferroptosis evasion and therapy resistance in cancer DOI Creative Commons
Jaewang Lee, Jong‐Lyel Roh

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2023, Номер 1869(7), С. 166788 - 166788

Опубликована: Июнь 10, 2023

Язык: Английский

Процитировано

31

Radiotherapy-induced ferroptosis for cancer treatment DOI Creative Commons
Giovanni Luca Beretta, Nadia Zaffaroni

Frontiers in Molecular Biosciences, Год журнала: 2023, Номер 10

Опубликована: Июнь 14, 2023

Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which very relevant for cancer therapy. Radiotherapy-induced ferroptosis critical tumor suppression several preclinical studies have demonstrated that the combination of ionizing radiation with small molecules or nano-systems effective in combating growth overcoming drug resistance. Here, we briefly overview mechanisms cross-talk existing between cellular pathways activated those induced radiotherapy. Lastly, discuss recently reported combinational involving radiotherapy, as well report recent findings achieved this field treatment tumors.

Язык: Английский

Процитировано

25

Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization DOI Creative Commons

Rui Qiao,

Zhongwen Yuan,

Meijin Yang

и другие.

Advanced Science, Год журнала: 2024, Номер 11(29)

Опубликована: Июнь 3, 2024

Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy

Язык: Английский

Процитировано

14

From ferroptosis to cuproptosis, and calcicoptosis, to find more novel metals-mediated distinct form of regulated cell death DOI
Jie Gu,

Chuanzhi Guo,

Jiacheng Ruan

и другие.

APOPTOSIS, Год журнала: 2024, Номер 29(5-6), С. 586 - 604

Опубликована: Фев. 7, 2024

Язык: Английский

Процитировано

13

Peptide‐Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy DOI

Xiaolin Duan,

Pin Wang,

Lulu He

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(37)

Опубликована: Фев. 9, 2024

Abstract The diagnosis and treatment of solid tumors have undergone significant advancements marked by a trend toward increased specificity integration imaging therapeutic functions. multifaceted nature inorganic oxide nanomaterials (IONs), which boast optical, magnetic, ultrasonic, biochemical modulatory properties, makes them ideal building blocks for developing multifunctional nanoplatforms. A promising class materials that emerged in this context are peptide‐functionalized (PFIONs), demonstrated excellent performance therapy, making potential candidates advancing tumor treatment. Owing to the functionalities peptides targeting, penetration, responsiveness, well‐designed PFIONs can specifically accumulate release or agents at sites, enabling precise effective This review provides an overview recent advances use tumors, highlighting superiority as well synergistic Moreover, discusses challenges prospects depth, aiming promote intersection interdisciplinary facilitate their clinical translation development personalized diagnostic systems optimizing material systems.

Язык: Английский

Процитировано

13

Cu2WS4‐PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno‐Radiotherapy by Inducing Ferroptosis DOI Creative Commons
Shiyan Fu,

Yong Li,

Li Shen

и другие.

Small, Год журнала: 2024, Номер 20(26)

Опубликована: Фев. 7, 2024

Unavoidable damage to normal tissues and tumor microenvironment (TME) resistance make it challenging eradicate breast carcinoma through radiotherapy. Therefore, is urgent develop radiotherapy sensitizers that can effectively reduce radiation doses reverse the suppressive TME. Here, a novel biomimetic PEGylated Cu

Язык: Английский

Процитировано

11

Oxygen Vacancy‐Rich Manganese Nanoflowers as Ferroptosis Inducers for Tumor Radiotherapy DOI
Ying Liu,

Fen Pi,

Lizhen He

и другие.

Small, Год журнала: 2024, Номер 20(32)

Опубликована: Март 20, 2024

Abstract The combination of ferroptosis and innovative tumor therapy methods offers another promising answer to the problem tumors. In order generate effective in cells, iron‐based nanomaterials are commonly utilized introduce foreign iron as a trigger for ferroptosis. However, this usually necessitates injection larger doses into body. These exogenous increases likely create concealed concerns symptoms such liver damage allergy. Herein, an iron‐free radiosensitizer is introduced, oxygen‐vacancy‐rich MnO 2 nanoflowers ( ovs ‐MnO ), that promotes modifies microenvironment assist radiotherapy. with enriched oxygen vacancies on surface induces release intracellular free (Fe 2+ which functions activator Fenton reaction enhances accumulation reactive species. On other hand, Fe also triggers lipid peroxides. Subsequently, depletion glutathione peroxidation cells leads inactivation peroxidase 4 (GPX4) ferroptosis, thereby enhancing therapeutic efficacy nanoplatform provides novel strategy generating nanomedicines ferroptosis‐assisted

Язык: Английский

Процитировано

11