Abstract
Ferroptosis
is
a
new
form
of
regulated
cell
death
featuring
iron‐dependent
lipid
peroxides
accumulation
to
kill
tumor
cells.
A
growing
body
evidence
has
shown
the
potential
ferroptosis‐based
cancer
therapy
in
eradicating
refractory
malignancies
that
are
resistant
apoptosis‐based
conventional
therapies.
In
recent
years,
studies
have
reported
number
ferroptosis
inducers
can
increase
vulnerability
cells
by
regulating
ferroptosis‐related
signaling
pathways.
Encouraged
rapid
development
ferroptosis‐driven
therapies,
interdisciplinary
fields
combine
ferroptosis,
pharmaceutical
chemistry,
and
nanotechnology
focused.
First,
prerequisites
metabolic
pathways
for
briefly
introduced.
Then,
detail
emerging
designed
boost
ferroptosis‐induced
therapy,
including
metal
complexes,
metal‐based
nanoparticles,
metal‐free
nanoparticles
summarized.
Subsequently,
application
synergistic
strategies
with
apoptosis
other
emphasis
on
use
both
cuproptosis
induce
redox
dysregulation
intracellular
bimetallic
copper/iron
metabolism
disorders
during
treatment
discussed.
Finally,
challenges
associated
clinical
translation
future
directions
potentiating
therapies
highlighted.
ACS Nano,
Год журнала:
2023,
Номер
17(20), С. 20445 - 20461
Опубликована: Окт. 6, 2023
Radiotherapy
is
inevitably
accompanied
by
some
degree
of
radiation
resistance,
which
leads
to
local
recurrence
and
even
therapeutic
failure.
To
overcome
this
limitation,
herein,
we
report
the
room-temperature
synthesis
an
iodine-
ferrocene-loaded
covalent
organic
framework
(COF)
nanozyme,
termed
TADI-COF-Fc,
for
enhancement
radiotherapeutic
efficacy
in
treatment
radioresistant
esophageal
cancer.
The
iodine
atoms
on
COF
not
only
exerted
a
direct
effect
radiotherapy,
increasing
its
X-ray
absorption,
but
also
promoted
radiolysis
water,
increased
production
reactive
oxygen
species
(ROS).
In
addition,
ferrocene
surface
decoration
disrupted
redox
homeostasis
levels
hydroxyl
lipid
peroxide
radicals
depleting
intracellular
antioxidants.
Both
vitro
vivo
experiments
substantiated
excellent
response
TADI-COF-Fc.
This
study
demonstrates
potential
COF-based
multinanozymes
as
radiosensitizers
suggests
possible
integration
strategy
combination
oncotherapy.
Frontiers in Molecular Biosciences,
Год журнала:
2023,
Номер
10
Опубликована: Июнь 14, 2023
Ferroptosis
is
a
regulated
cell
death
mechanism
controlled
by
iron,
amino
acid
and
reactive
oxygen
species
metabolisms,
which
very
relevant
for
cancer
therapy.
Radiotherapy-induced
ferroptosis
critical
tumor
suppression
several
preclinical
studies
have
demonstrated
that
the
combination
of
ionizing
radiation
with
small
molecules
or
nano-systems
effective
in
combating
growth
overcoming
drug
resistance.
Here,
we
briefly
overview
mechanisms
cross-talk
existing
between
cellular
pathways
activated
those
induced
radiotherapy.
Lastly,
discuss
recently
reported
combinational
involving
radiotherapy,
as
well
report
recent
findings
achieved
this
field
treatment
tumors.
Abstract
Exploring
efficient
and
low‐toxicity
radiosensitizers
to
break
through
the
bottleneck
of
radiation
tolerance,
immunosuppression
poor
prognosis
remains
one
critical
developmental
challenges
in
radiotherapy.
Nanoheterojunctions,
due
their
unique
physicochemical
properties,
have
demonstrated
excellent
radiosensitization
effects
energy
deposition
lifting
tumor
radiotherapy
inhibition.
Herein,
they
doped
selenium
(Se)
into
prussian
blue
(PB)
construct
a
nano‐heterojunction
(Se@PB),
which
could
promote
increase
Fe
2+
/Fe
3+
ratio
conversion
Se
high
valence
state
with
introduction.
The
‐Se‐Fe
electron
transfer
chain
accelerates
rate
on
surface
nanoparticles,
turn
endows
it
X‐ray
transport
capability,
enhances
physical
sensitivity.
Furthermore,
Se@PB
induces
glutathione
(GSH)
depletion
accumulation
pro‐Fenton
reaction,
thereby
disturbs
redox
balance
cells
biochemical
sensitivity
As
an
radiosensitizer,
effectively
induced
mitochondrial
dysfunction
DNA
damage,
promotes
cell
apoptosis
synergistic
cervical
cancer
This
study
elucidates
mechanism
Se‐doped
nanoheterojunction
from
perspective
biochemistry
provides
low‐toxic
strategy
Advanced Materials,
Год журнала:
2024,
Номер
36(37)
Опубликована: Фев. 9, 2024
Abstract
The
diagnosis
and
treatment
of
solid
tumors
have
undergone
significant
advancements
marked
by
a
trend
toward
increased
specificity
integration
imaging
therapeutic
functions.
multifaceted
nature
inorganic
oxide
nanomaterials
(IONs),
which
boast
optical,
magnetic,
ultrasonic,
biochemical
modulatory
properties,
makes
them
ideal
building
blocks
for
developing
multifunctional
nanoplatforms.
A
promising
class
materials
that
emerged
in
this
context
are
peptide‐functionalized
(PFIONs),
demonstrated
excellent
performance
therapy,
making
potential
candidates
advancing
tumor
treatment.
Owing
to
the
functionalities
peptides
targeting,
penetration,
responsiveness,
well‐designed
PFIONs
can
specifically
accumulate
release
or
agents
at
sites,
enabling
precise
effective
This
review
provides
an
overview
recent
advances
use
tumors,
highlighting
superiority
as
well
synergistic
Moreover,
discusses
challenges
prospects
depth,
aiming
promote
intersection
interdisciplinary
facilitate
their
clinical
translation
development
personalized
diagnostic
systems
optimizing
material
systems.
Unavoidable
damage
to
normal
tissues
and
tumor
microenvironment
(TME)
resistance
make
it
challenging
eradicate
breast
carcinoma
through
radiotherapy.
Therefore,
is
urgent
develop
radiotherapy
sensitizers
that
can
effectively
reduce
radiation
doses
reverse
the
suppressive
TME.
Here,
a
novel
biomimetic
PEGylated
Cu
Abstract
The
combination
of
ferroptosis
and
innovative
tumor
therapy
methods
offers
another
promising
answer
to
the
problem
tumors.
In
order
generate
effective
in
cells,
iron‐based
nanomaterials
are
commonly
utilized
introduce
foreign
iron
as
a
trigger
for
ferroptosis.
However,
this
usually
necessitates
injection
larger
doses
into
body.
These
exogenous
increases
likely
create
concealed
concerns
symptoms
such
liver
damage
allergy.
Herein,
an
iron‐free
radiosensitizer
is
introduced,
oxygen‐vacancy‐rich
MnO
2
nanoflowers
(
ovs
‐MnO
),
that
promotes
modifies
microenvironment
assist
radiotherapy.
with
enriched
oxygen
vacancies
on
surface
induces
release
intracellular
free
(Fe
2+
which
functions
activator
Fenton
reaction
enhances
accumulation
reactive
species.
On
other
hand,
Fe
also
triggers
lipid
peroxides.
Subsequently,
depletion
glutathione
peroxidation
cells
leads
inactivation
peroxidase
4
(GPX4)
ferroptosis,
thereby
enhancing
therapeutic
efficacy
nanoplatform
provides
novel
strategy
generating
nanomedicines
ferroptosis‐assisted