International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139103 - 139103
Опубликована: Дек. 1, 2024
Язык: Английский
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Май 1, 2024
Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known death mechanisms. This process involves the interaction copper with lipoylated tricarboxylic acid cycle enzymes, causing protein aggregation death. Recently, growing number studies have explored link between cuproptosis cancer development. review comprehensively examines systemic metabolism copper, including tumor-related signaling pathways influenced by copper. It delves into discovery mechanisms connection various cancers. Additionally, suggests potential treatments using ionophores that induce combination small molecule drugs, for precision therapy specific types.
Язык: Английский
Процитировано
18
Nano Letters, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Dual atomic nanozymes (DAzymes) are promising for applications in the field of tumor catalytic therapy. Here, integrating with ultrasmall Fe5C2 nanoclusters, asymmetric coordination featuring Janus Zn-Fe dual-atom sites an O2N2-Fe-Zn-N4 moiety embedded a carbon vacancy-engineered hollow nanobox (Janus ZnFe DAs-Fe5C2) was elaborately developed. Theoretical calculation revealed that synergistic effects Zn centers acting as both adsorption and active sites, oxygen-heteroatom doping, vacancy, nanoclusters jointly downshifted d-band center Fe 3d orbitals, optimizing desorption behaviors intermediates *OH, thereby significantly promoting activity. Upon 1064 nm laser irradiation, DAs-Fe5C2 superior photothermal conversion efficiency (η = 62.5%) showed thermal-augmented Fascinatingly, multienzymatic properties can suppress expression glutathione peroxidase 4 accelerate accumulation lipid peroxides, through which ferroptosis is triggered. Overall, tannin-involved will inspire more inventions biodegradable DAzymes therapy application.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160751 - 160751
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 20, 2025
Nitric oxide (NO)-based gas therapy has attracted increasing attention as a promising approach for tumor treatment, but elevated levels of glutathione (GSH) in the microenvironment significantly limit their therapeutic effectiveness. In this study, type engineered photoactivatable nanomicelles Ce6/NI@PEP@HA (CNPH) were developed combinational photodynamic and NO therapy. CNPH was capable targeted accumulation to tumors, where it depleted GSH released effectively produce reactive oxygen species (ROS) with oxidative damage under laser irradiation at 660 nm. The consumption induced deactivation peroxidase activity, leading enhanced toxic lipid peroxide enabled ferroptosis-like outcome. Additionally, effective production ROS resulted mitochondrial dysfunction, characterized by disruption membrane potential decreased adenosine triphosphate concentration. vivo animal experiments indicated that achieved inhibition 89.1%, proven be more strategy contrast any single modality. consequence, opened up new horizon cutting-edge noninvasive paradigm advanced treatments.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 26, 2025
Abstract Background Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge. Methods We explore approach that enables induction through external radiation. The key component of this technology 7-dehydrocholesterol (7DHC), natural biosynthetic precursor cholesterol. To facilitate delivery, we demonstrate 7DHC, like cholesterol, can be incorporated into the layer liposomes. enhance targeting, also introduced NTS mut , ligand for neurotensin receptor 1 (NTSR1), which overexpressed multiple malignancies, Results Under radiation, 7DHC reacts with radiation-induced reactive oxygen species (ROS), initiating radical chain reaction polyunsaturated fatty acids (PUFAs) membranes. This process results direct peroxidation and subsequent ferroptotic death. In vivo studies -conjugated, 7DHC-loaded liposomes (N-7DHC-lipos) effectively accumulate tumors significantly efficacy radiation therapy. Conclusion While conventional radiosensitizers primarily target DNA its repair mechanisms, our study introduces strategy to radiotherapy specifically activating within irradiated area, thereby minimizing systemic toxicity. Such controlled activation offers favorable therapeutic index potentially opens avenues clinical application.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161307 - 161307
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116667 - 116667
Опубликована: Май 3, 2024
Regulated cell death (RCD) is a form of that can be regulated by numerous biomacromolecules. Accumulating evidence suggests dysregulated expression and altered localization related proteins in RCD promote the development cancer. Targeting subroutines with pharmacological small-molecule compounds becoming promising therapeutic avenue for anti-tumor treatment, especially hematological malignancies. Herein, we summarize aberrant mechanisms apoptosis, necroptosis, pyroptosis, PANoptosis, ferroptosis In particular, focus on relationship between tumorigenesis, immunotherapy, drug resistance Furthermore, discuss emerging strategies targeting different subroutines. This review aims to significance potential malignancies, along utilization pertinent strategies.
Язык: Английский
Процитировано
3
Heliyon, Год журнала: 2024, Номер 10(18), С. e37613 - e37613
Опубликована: Сен. 1, 2024
Oxaliplatin (OXA)-based therapy is effective in the treatment of multiple cancers. However, primary or acquired OXA resistance remains an emerging challenge for its clinical application. Ferroptosis iron-dependent mode cell death that has been demonstrated to play essential role chemoresistance many drugs, including OXA. In particular, dysregulation SLC7A11-GPX4, one major antioxidant systems ferroptosis, was found colorectal cancer (CRC) and hepatocellular carcinoma (HCC). addition, Nrf2, upstream regulator GPX4 other factors, also involved CRC HCC. Inhibition SLC7A11-GPX4 Nrf2 by genetic deletion pharmaceutical inhibition could significantly reverse resistance. Long noncoding RNA (lncRNA) participates ferroptosis cells. Specifically, LINC01134 promotes recruitment promoter GPX4, thereby exerting transcriptional regulation which eventually increases sensitivity HCC through upregulation ferroptosis. On hand, a novel lncRNA DACT3-AS1 sensitizes gastric cells miR-181a-5p/sirtuin 1(SIRT1)-mediated Therapies based on combination enhancers provide new therapeutic insights overcome present review, we current understanding ferroptosis-related resistance, highlight pathogenesis chemoresistance, summarize available therapies target enhancing
Язык: Английский
Процитировано
2
Journal of Medicinal Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Chemoresistance remains an arduous challenge in oncology, but ferroptosis shows potential for overcoming it by stimulating the immune system. Herein, a novel high-performance ruthenium(II)-based arene complex [Ru(η
Язык: Английский
Процитировано
2
Journal of Food Composition and Analysis, Год журнала: 2024, Номер 132, С. 106282 - 106282
Опубликована: Апрель 26, 2024
Язык: Английский
Процитировано
1