Analysis of global research hotspots and trends in immune cells in intervertebral disc degeneration: A bibliometric study DOI Creative Commons
Nan Wang,

Zehua Mi,

Shuang Chen

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(3)

Published: Nov. 9, 2023

Intervertebral disc degeneration is an important pathological basis for spinal degenerative diseases. The imbalance of the immune microenvironment and involvement cells has been shown to lead nucleus pulposus death. This article presents a bibliometric analysis studies on in IDD order clarify current status hotspots. We searched WOSCC, Scopus PubMed databases from 01/01/2001 08/03/2023. analyzed visualized content using software such as Citespace, Vosviewer bibliometrix. study found that number annual publications increasing year year. journal Spine had highest articles citations. country/regions showed China publications, USA citations total link strength. institutional Shanghai Jiao Tong University Huazhong Science Technology Tokai citations, Bern Sakai D Risbud MV publications. strength, results keyword suggested research hotspots future directions continue be mechanisms IDD, therapeutic role tissue engineering IDD.

Language: Английский

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy DOI Creative Commons

Ming‐Hui Fan,

Jin-Kui Pi,

Chen‐Yu Zou

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 1 - 30

Published: April 23, 2024

Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.

Language: Английский

Citations

21
Organoid and organoid extracellular vesicles for osteoporotic fractures therapy: Current status and future perspectives DOI Creative Commons
Han Liu, Jiacan Su

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(3)

Published: July 1, 2023

Abstract Osteoporosis is a systemic and degenerative disease characterized by low bone mass fragile microarchitecture, which predispose patients to fragility fractures, also known as osteoporotic fractures (OPF). OPF have become major social problem that threaten the health of elderly. Over past decade, organoids extracellular vesicles (OEVs) play significant role in repair. Organoids been widely used for treatment. Moreover, EVs are promising nanocarriers due their cell‐free system, stable drug loading capacity, nanometer size, good biocompatibility. Importanly, compared with traditional EVs, OEVs more quantity, better physiological effects, therapeutic effects. Therefore, development organoid treatment great significance. Here, we summarize current status future perspectives OEVs, will provide innovative solutions

Language: Английский

Citations

26
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration DOI Creative Commons
Hussein H. Genedy, P. Humbert,

Bilel Laoulaou

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115214 - 115214

Published: Feb. 22, 2024

Language: Английский

Citations

13
A new strategy for intervertebral disc regeneration: The synergistic potential of mesenchymal stem cells and their extracellular vesicles with hydrogel scaffolds DOI Open Access
Yan Zhao,

Huaize Dong,

Qiuqiu Xia

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 172, P. 116238 - 116238

Published: Feb. 3, 2024

Intervertebral disc degeneration (IDD) is a disease that severely affects spinal health and prevalent worldwide. Mesenchymal stem cells (MSCs) their derived extracellular vesicles (EVs) have regenerative potential emerged as promising therapeutic tools for treating degenerative discs. However, challenges such the harsh microenvironment of degenerated intervertebral discs EVs' limited stability efficacy hindered clinical application. In recent years, hydrogels attracted much attention in field IDD therapy because they can mimic physiologic provide solution by providing suitable growth environment MSCs EVs. This review introduced biological properties EVs, summarized research on application EVs IDD, current trial studies also explored mechanism action addition, plenty elaborated different classified tissue engineering, synergistic effect promoting regeneration, wide IDD. Finally, problems still faced hydrogel-loaded treatment are summarized, solutions proposed. paper outlines effects combination with aims to theoretical references future related studies.

Language: Английский

Citations

11
Injectable Hydrogel Based on Enzymatic Initiation of Keratin Methacrylate for Controlled Exosome Release in Intervertebral Disc Degeneration Therapy DOI
Linjie Chen, Ke Peng,

He Huang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: April 5, 2024

Abstract The treatment of intervertebral disc degeneration (IVDD) using bone marrow mesenchymal stem cell‐derived exosomes has shown success in alleviating inflammation and restoring the extracellular matrix (ECM), however, challenges persist due to deficiency mechanical support controlled release. Herein, a carbon‐carbon double bond modified keratin (KeMA) is synthesized by 2‐isocyanatoethyl modification for wrapping. This injectable KeMA hydrogel, initiated biocompatible glucose/ glucose oxidase/ horse radish peroxidase enzymatic cascade reaction with acetylacetone N‐vinylpyrrolidone, displayed rapid gelation, resembling nucleus pulposus (NP) elasticity, excellent cytocompatibility. In vitro studies showcased that exosomes‐loaded hydrogel (Exo@KeMA) enhanced exosome release kinetics, suppressed inflammation, fostered (ECM) regeneration, reinstated NP biomechanics. RNA‐seq analysis indicated Exo@KeMA's effects involved PI3K‐Akt signaling regeneration NF‐κB inhibition anti‐inflammation. vivo IVDD rat models demonstrated Exo@KeMA attenuated maintained water content, preserved height, promoted structural regeneration. research introduces an as promising therapy IVDD, facilitating biomechanics restoration, anti‐inflammatory response, ECM

Language: Английский

Citations

8
Innovating intervertebral disc degeneration therapy: Harnessing the power of extracellular vesicles DOI Creative Commons
Shanfeng Chen,

Yiming Dou,

Yiming Zhang

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 44 - 55

Published: Jan. 1, 2025

Language: Английский

Citations

1
Stem cell-derived extracellular vesicles as senotherapeutics DOI

Ekaterina Rudnitsky,

Alex Braiman,

Marina Wolfson

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102391 - 102391

Published: June 22, 2024

Language: Английский

Citations

6
Signaling pathways activated and regulated by stem cell-derived exosome therapy DOI Creative Commons

Ding Li,

Danni Li, Zhao Wang

et al.

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 20, 2024

Stem cell-derived exosomes exert comparable therapeutic effects to those of their parental stem cells without causing immunogenic, tumorigenic, and ethical disadvantages. Their advantages are manifested in the management a broad spectrum diseases, dosing versatility exemplified by systemic administration local delivery. Furthermore, activation regulation various signaling cascades have provided foundation for claimed curative exosomal therapy. Unlike other relevant reviews focusing on upstream aspects (e.g., yield, isolation, modification), downstream (e.g. phenotypic changes, tissue response, cellular behavior) exosome therapy, this unique review endeavors focus affected pathways. After meticulous dissection literature from past five years, we present comprehensive, up-to-date, disease-specific, pathway-oriented review. Exosomes sourced types can regulate major pathways PTEN/PI3K/Akt/mTOR, NF-κB, TGF-β, HIF-1α, Wnt, MAPK, JAK-STAT, Hippo, Notch cascades) minor during treatment numerous diseases encountered orthopedic surgery, neurosurgery, cardiothoracic plastic general specialties. We provide novel perspective future research through bridging gap between surgical indications when designing further preclinical studies clinical trials.

Language: Английский

Citations

6
PGC1α‐Inducing Senomorphic Nanotherapeutics Functionalized with NKG2D‐Overexpressing Cell Membranes for Intervertebral Disc Degeneration DOI Creative Commons
Sheng Liu,

Kanglu Li,

Yuxin He

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)

Published: March 30, 2024

Abstract Cellular senescence is a significant contributor to intervertebral disc aging and degeneration. However, the application of senotherapies, such as senomorphics targeting markers senescence‐associated secretory phenotype (SASP), remains limited due challenges in precise delivery. Given that natural killer group 2D (NKG2D) ligands are increased on surface senescent nucleus pulposus (NP) cells, NKG2D‐overexpressing NP cell membranes (NNPm) constructed, which expected achieve dual effect toward cells based homologous membrane fusion NKG2D‐mediated immunosurveillance mechanism. Then, mesoporous silica nanoparticles carrying peroxisome proliferator‐activated receptor‐ɣ coactivator 1α (PGC1α)inducer (SP) coated with NNPm (SP@NNPm) it found SP@NNPm selectively targets SP cores exhibit pH‐responsive drug release. Moreover, effectively induces PGC1α‐mediated mitochondrial biogenesis mitigates induced by oxidative stress SASP, thereby alleviating puncture‐induced This dual‐targeting nanotherapeutic system represents novel approach delivery for degeneration treatment.

Language: Английский

Citations

5
Spotlight on necroptosis: Role in pathogenesis and therapeutic potential of intervertebral disc degeneration DOI

Rui Ran,

Shun-Bai Zhang,

Yong-Qiang Shi

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112616 - 112616

Published: July 2, 2024

Language: Английский

Citations

5