Application of metal–organic framework materials in regenerative medicine

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(35), С. 8543 - 8576

Опубликована: Янв. 1, 2024

Applications of nano-MOFs in bone tissue engineering, wound healing, and others, including periodontitis, tendon repair, nerve cardiovascular disease. Created with BioRender.com.

Язык: Английский

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Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Abstract Maintaining microbiota balance and enhancing the antioxidant performance of nanozyme‐based probiotic systems are crucial for effective inflammatory bowel disease (IBD) therapy. Despite significant advancements, developing a green safe coating technology that functionalizes probiotics with nanozymes while preserving activity both components remains challenge. To address this, chitosan‐modified epigallocatechin gallate (EGCG‐CS, EC)is synthesized, leveraging intrinsic adhesive coordination properties polyphenols to capture gold (AuNPs), forming ECA complexes enhance nanozyme activity. When coated onto Escherichia coli Nissle 1917 (EcN), resulting ECA@EcN system effectively scavenged reactive oxygen species (ROS), improving viability promoting colon accumulation. Mechanistically, protected EcN by suppressing activation Flagellar Assembly Branched‐Chain Amino Acid Synthesis pathways, ultimately alleviating inflammation modulating intestinal microbial communities relieve IBD symptoms. Given biocompatibility its environmentally friendly assembly approach, this polyphenol‐nanozyme‐armored represents promising platform treatment.

Язык: Английский

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Baicalein based nano-delivery system restores mitochondrial homeostasis through PPAR signaling pathway to promote wound healing in diabetes

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Май 19, 2025

Wound healing in diabetes is a substantial clinical challenge due to the hyperglycemic microenvironment, high pH, bacterial infection, persistent inflammation, and impaired cellular functions, attributed mitochondrial dysfunction. Here, we have developed an injectable photo-crosslinking nanocomposite hydrogel (BA/GOx@ZIF-8@GelMA, BGZ@GelMA) with baicalein (BA) glucose oxidase (GOx) loaded Zinc metal-organic framework (ZIF-8) based on methacrylated gelatin (GelMA) accelerate diabetic infected wound by regulating subcellular functions. The combination of ZIF-8 BA gives excellent antibacterial properties. A blood sugar environment triggers release GOx BGZ@GelMA, reducing local producing hydrogen peroxide (H2O2), releasing ions (Zn2+). This process provides suitable microenvironment for healing. Zn2+ can significantly inhibit proliferation Staphylococcus aureus (S.aureus) Escherichia coli (E.coli). released clear ROS cells mitochondria, restore function stability, make fundamentally improve cell damage induced hyperglycemia, ultimately promote proliferation, migration angiogenesis. In general, our multifunctional new strategy at functional levels.

Язык: Английский

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Nanozymes With Osteochondral Regenerative Effects: An Overview of Mechanisms and Recent Applications

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)

Опубликована: Авг. 26, 2023

Abstract With the discovery of intrinsic enzyme‐like activity metal oxides, nanozymes garner significant attention due to their superior characteristics, such as low cost, high stability, multi‐enzyme activity, and facile preparation. Notably, in field biomedicine, primarily focus on disease detection, antibacterial properties, antitumor effects, treatment inflammatory conditions. However, potential for application regenerative medicine, which addresses wound healing, nerve defect repair, bone regeneration, cardiovascular treatment, is garnering interest well. This review introduces an innovative strategy within realm medicine. The primary this approach lies facilitation osteochondral regeneration through modulation pathological microenvironment. catalytic mechanisms four types representative are first discussed. microenvironment inhibiting followed by summarizing therapy mechanism barriers introduced. Further, therapeutic diseases included. To improve efficiency facilitate clinical translation, future applications also discussed some challenges addressed.

Язык: Английский

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Zeolite imidazolate framework-8 in bone regeneration: A systematic review

Journal of Controlled Release, Год журнала: 2023, Номер 365, С. 558 - 582

Опубликована: Дек. 6, 2023

Язык: Английский

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