Osteochondral
injuries
represent
prevalent
clinical
conditions
with
profound
implications
for
functional
impairment
and
diminished
quality
of
life.
Despite
the
considerable
potential
tissue
engineering
in
osteochondral
repair,
substantial
strides
implementation
remain
elusive.
Biomimetic
materials,
designed
to
emulate
natural
cartilage,
offer
a
stabilized
structure
microenvironment
capable
accommodating
diverse
properties
inherent
different
cartilage
regions.
Smart
endowed
ability
deliver
drugs,
metal
ions,
growth
factors
contingent
on
disease
progression,
exert
precise
control
over
cellular
epigenetic
behaviors.
This
review
scrutinizes
nuanced
characteristics
both
physiological
pathological
states.
Subsequently,
succinct
overview
recent
applications
biomaterials
bionic
smart
attributes
regeneration
repair
is
provided.
Finally,
we
propose
our
perspectives
application
biomimetic-smart
materials
emphasizing
their
translation.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июль 1, 2024
Osteoarthritis
(OA)
is
a
degenerative
disease
linked
to
aging
and
obesity.
The
global
population
has
led
an
increasing
number
of
OA
patients,
imposing
significant
economic
burden
on
society.
Traditional
drugs
treatment
methods
often
fail
achieve
satisfactory
outcomes.
With
the
rapid
advancement
nanomaterial
delivery
systems,
numerous
studies
have
focused
utilizing
nanomaterials
as
carriers
efficient
by
effectively
loading
delivering
bioactive
ingredients
(e.g.,
drugs,
nucleic
acids)
tailored
unique
pathological
conditions,
such
weakly
acidic
microenvironment
synovial
fluid
in
patients.
This
review
highlights
latest
advancements
use
pH-responsive
nanoparticles
for
treatment,
emphasizing
principle
targeted
drug
leveraging
inflamed
joints.
It
further
discusses
composition,
synthesis,
response
mechanism,
target
selection,
application,
recent
research
findings
nanoparticles,
while
also
addressing
challenges
future
directions
this
promising
field.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 6731 - 6756
Опубликована: Июль 1, 2024
Abstract:
Osteoarthritis
(OA)
is
the
most
common
degenerative
joint
disease,
affecting
more
than
595
million
people
worldwide.
Nanomaterials
possess
superior
physicochemical
properties
and
can
influence
pathological
processes
due
to
their
unique
structural
features,
such
as
size,
surface
interface,
photoelectromagnetic
thermal
effects.
Unlike
traditional
OA
treatments,
which
suffer
from
short
half-life,
low
stability,
poor
bioavailability,
high
systemic
toxicity,
nanotherapeutic
strategies
for
offer
longer
enhanced
targeting,
improved
reduced
toxicity.
These
advantages
effectively
address
limitations
of
therapies.
This
review
aims
inspire
researchers
develop
multifunctional
nanomaterials
promote
practical
application
in
treatment.
Keywords:
nanostructures,
osteoarthritis,
drug
delivery
systems,
nanomedicine,
precision
medicine
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 25, 2024
Notable
progress
has
been
made
in
"ferroptosis-based
nano
drug
delivery
systems
(NDDSs)"
over
the
past
11
years.
Despite
ongoing
absence
of
a
comprehensive
scientometric
overview
and
up-to-date
scientific
mapping
research,
especially
regarding
evolution,
critical
research
pathways,
current
landscape,
central
investigative
themes,
future
directions.
Photofunctional
nanomaterials
have
shown
great
potential
in
biomedical
applications
due
to
their
unique
optical
properties
and
size
effects.
This
chapter
focuses
on
"General
Introduction
Background
of
Nanomaterials
Biomedical
Applications."
First,
a
brief
introduction
is
given,
describing
basic
importance
various
fields.
Secondly,
the
concepts
photofunctional
physicochemical
effects
under
light
conditions,
such
as
photothermal
effect,
photoluminescence,
photovoltaic
photochemical
are
presented.
Next,
an
overview
nanobiomedicine
presented,
highlighting
for
applications.
Then,
different
types
nanomaterials,
including
fluorescent,
photothermal,
photodynamic,
photoelectrochemical
photoacoustic
discussed
detailed
classification
fields
bioimaging,
antimicrobial,
oncological
diagnosis
treatment,
biodetection
sensing
discussed.
Finally,
current
research
results
summarized
future
development
field
envisaged.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 17, 2025
Osteoarthritis
is
one
of
the
most
common
degenerative
joint
diseases,
which
seriously
affects
life
middle-aged
and
elderly
people.
Traditional
treatments
such
as
surgical
treatment
systemic
medication,
often
do
not
achieve
expected
or
optimal
results,
leads
to
severe
trauma
a
variety
side
effects.
Therefore,
there
an
urgent
need
develop
novel
therapeutic
options
overcome
these
problems.
Hydrogels
are
widely
used
in
biomedical
tissue
repairing
platform
for
loading
drugs,
proteins
stem
cells.
In
recent
years,
smart-responsive
hydrogels
have
achieved
excellent
results
drug
delivery
systems
osteoarthritis.
This
review
focuses
on
advances
endogenous
stimuli
(including
enzymes,
pH,
reactive
oxygen
species
temperature,
etc.)
responsive
exogenous
light,
shear,
ultrasound
magnetism,
osteoarthritis
treatment.
Finally,
current
limitations
application
future
prospects
smart
summarized.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Abstract
Abnormal
friction
forces,
compact
matrix
structure,
and
dynamic
acidic
microenvironment
in
osteoarthritis
(OA)
make
it
difficult
to
remodel
cartilage
regeneration
by
integrating
prominent
inflammatory
responses
anabolism.
Here,
pH‐responsive
PSBMA‐
b
‐PColBP@KGN
nanoparticles
(PSPK
NPs)
are
developed
a
simple
supramolecular
assembly
process.
PSPK
NPs
found
reduce
the
coefficient
of
(0.028)
under
high
loading
pressure
(10.41
MPa).
The
synergistic
effect
KGN
release
coupling
deep
penetration
promotes
generation
microenvironment.
Further,
vivo
studies
confirm
potential
restoring
homeostasis,
as
evidenced
reduced
osteophyte
volume,
aligned
structures,
abundant
matrix.
This
study
provides
novel
insights
into
effects
release,
penetration,
hydration
lubrication
on
OA
treatment,
offering
strategy
for
design
tissue‐adaptive
promote
tissue
inflammation‐related
diseases.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(24), С. 5769 - 5786
Опубликована: Янв. 1, 2024
Neuromodulation
aims
to
modulate
the
signaling
activity
of
neurons
or
neural
networks
by
precise
delivery
electrical
stimuli
chemical
agents
and
is
crucial
for
understanding
brain
function
treating
disorders.
Conventional
approaches,
such
as
direct
physical
stimulation
through
acoustic
methods,
confront
challenges
stemming
from
their
invasive
nature,
dependency
on
wired
power
sources,
unstable
therapeutic
outcomes.
The
emergence
stimulus-responsive
systems
harbors
potential
revolutionize
neuromodulation
strategies
controlled
release
neurochemicals
in
a
specific
region.
This
review
comprehensively
examines
biological
barriers
may
encounter
vivo
recent
advances
applications
these
neuromodulation.
We
elucidate
intricate
interplay
between
molecular
structure
response
mechanisms
furnish
insights
material
selection
design.
Additionally,
contemplates
prospects
associated
with
overarching
objective
propel
application
technology
analyzing
functions,
disorders,
providing
insightful
perspectives
exploiting
new
biomedical
applications.
