Mechanical Stimulation of Anti‐Inflammatory and Antioxidant Hydrogels for Rapid Re‐Epithelialization

Advanced Materials, Год журнала: 2024, Номер 36(18)

Опубликована: Янв. 26, 2024

Abstract The epithelium, an essential barrier to protect organisms against infection, exists in many organs. However, rapid re‐epithelialization restore tissue integrity and function adverse environment is challenging. In this work, a long‐term anti‐inflammatory antioxidant hydrogel with mechanical stimulation for re‐epithelialization, mainly composed of the small molecule thioctic acid, biocompatible glycine, γ‐Fe 2 O 3 nanoparticles reported. Glycine‐modified supramolecular acid stable possesses outstanding properties. incorporating providing potential contrast magnetic resonance imaging observation, can propel reconfiguration enhance properties underwater due water‐initiated release Fe 3+ . vitro experiments show that hydrogels effectively reduced intracellular reactive oxygen species, guided macrophages toward M2 polarization, alleviated inflammation. effect ultimately demonstrated long urethral injury model vivo, achieves effective functional replacement accurate remodeling epithelium. Notably, proposed strategy provides advanced alternative treatment patients need large‐area epithelial reconstruction.

Язык: Английский

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Versatile Stretchable Conductor with Exceptional Resilience and Rapid Rebound Capabilities: Toward Sustainable and Damage‐Resistant Soft Electronics

Advanced Functional Materials, Год журнала: 2023, Номер 34(16)

Опубликована: Дек. 29, 2023

Abstract Stretchable conductors (SCs) have garnered significant attention in both academia and industry, owing to their promising applications flexible electronics. However, achieving a highly resilient rapidly rebounding SC that enables prompt electrical response applied strain, while also being fully recyclable self‐healable, remains challenge. Here, the design preparation of high‐performance based on small bio‐molecule (α‐Lipoic acid) are reported, using straightforward, cost‐effective, scalable method. The engineered exhibits ≈100% rebound ratio fast speed (≈0.4 s) under repeated high strains, along with outstanding sensitivity deformation temperature variation. This ensures possesses precision real‐time sensing attributes. Moreover, features optical transparency (>97%), robust reversible adhesion diverse surfaces (up 5.0 MPa), efficient room‐temperature self‐healing properties, full recyclability. superior properties fundamentally attributed installed hierarchical dynamic bonding at molecular level, which continuous energy dissipation is analyzed through DFT calculations. developed holds great potential for soft electronics human–machine interfaces.

Язык: Английский

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Biological applications of lipoic acid-based polymers: an old material with new promise

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(19), С. 4574 - 4583

Опубликована: Янв. 1, 2024

Lipoic acid (LA) is a versatile antioxidant that has been used in the treatment of various oxidation-reduction diseases over past 70 years. Owing to its large five-membered ring tension, dynamic disulfide bond LA highly active, enabling formation poly(lipoic acid) (PLA) via ring-opening polymerization (ROP). Herein, we first summarize disulfide-mediated ROP strategies, providing basic routes for designing and preparing PLA-based materials. PLA, as biologically derived, low toxic, easily modified material, possesses bonds universal non-covalent carboxyl groups. We also shed light on biomedical applications materials based their biological structural features further divide recent works into six categories: antibacterial, anti-inflammation, anticancer, adhesive, flexible electronics, 3D-printed tissue scaffolds. Finally, challenges future prospects associated with PLA are discussed.

Язык: Английский

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High-performance solid-state ion-conductive elastomer based on multiple noncovalent interactions for flexible sensors

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159776 - 159776

Опубликована: Янв. 1, 2025

Язык: Английский

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Biomass and Transparent Supramolecular Elastomers for Green Electronics Enabled by the Controlled Growth and Self‐Assembly of Dynamic Polymer Networks

Small, Год журнала: 2024, Номер 20(45)

Опубликована: Июль 18, 2024

Determining the optimal method for preparing supramolecular materials remains a profound challenge. This process requires combination of renewable raw to create with multiple functions and properties, including simple fabrication, sustainability, dynamic nature, good toughness, transparency. In this work, strategy is presented toughening networks based on solid-phase chain extension. environmentally friendly. addition, series biobased elastomers are designed prepared adjustable performance characteristics. can significantly improve transparency, tensile strength, toughness synthesized elastomer. The have great ductility, repairability, recyclability, they show adhesion dielectric properties. A ionic skin assembled from these elastomers. Assembled sensitively detect external stimuli (such as stretching, bending, compression, or temperature changes) monitor human movement. conductive layers both obtained materials. research provides novel molecular design approaches material selection methods promoting development green electronic devices

Язык: Английский

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Thioctic Acid-Based Solvent-Free and Recoverable Adhesive for Dry/Wet Environments

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Сен. 24, 2024

Metal adhesive synthesis typically involves heating and solvents, the resultant adhesives lack degradability suffer from recycling sustainable problems. Herein, we developed a solvent-free chemically degradable biobased (p(Elp-TA)+PVP) thioctic acid (TA), its derivative (Elp), polyvinylpyrrolidone (PVP). Through rapid acid-triggered cationic ring-opening polymerization of dithiolane at ambient conditions, p(Elp-TA)+PVP could build up strong lap shear strength 1123 kPa in air an underwater 534 to copper plate. Molecular dynamics simulations show that compared p(Elp-TA), presence appropriate amount PVP can significantly enhance binding energy molecules metal substrate, adhesion substrates was achieved through synergistically dynamic adaptive network enhanced by hydrogen bonding, reversible coordination bonding 40 ps. More importantly, applied be easily degraded reverted small-molecular-weight lipoic species. Upon exposure dithiothreitol, green reducing agent, average molecular weight quickly decrease 1603 kDa 274 Da. This constructed simple method provides promising general strategy for developing controlled recoverable natural resources.

Язык: Английский

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Nucleotide‐Tackified Degradable and Closed‐Loop Recyclable Underwater Adhesive

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 28, 2024

Abstract Sustainable underwater adhesives have drawn much interest in promising applications and environmental engineering. However, developing a convenient strategy to combine recyclability adhesion into adhesive materials remains formidable challenge. In this work, degradable closed‐loop recyclable tackifier is designed by nucleotide, via the ring‐opening polymerization of thioctic acid presence 5′‐adenosine monophosphate methacrylatoethyl trimethyl ammonium chloride. The nucleotide‐tackified present an excellent for various materials, tissues, on‐demand detachment behavior. demonstrate reusability, degradability, dual monomers monophosphate. Interestingly, waste residues processability can be employed again construction tough interfaces both air underwater, with further expanding sustainability. It envisioned that sustainable would offer insights advancing materials.

Язык: Английский

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Study on fabricating transparent, stretchable, and self-healing ionic conductive elastomers from biomass molecules through solvent-free synthesis

Journal of Materials Chemistry A, Год журнала: 2023, Номер 11(30), С. 16074 - 16083

Опубликована: Янв. 1, 2023

We propose a simple and effective strategy for increasing the conductivity of polyTA by copolymerization reactions, series autonomously self-healing, transparent, liquid-free ionic conductors was prepared.

Язык: Английский

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Bioinspired Polymers: Transformative Applications in Biomedicine and Regenerative Medicine

Life, Год журнала: 2023, Номер 13(8), С. 1673 - 1673

Опубликована: Авг. 1, 2023

Bioinspired polymers have emerged as a promising field in biomaterials research, offering innovative solutions for various applications biomedical engineering. This manuscript provides an overview of the advancements and potential bioinspired tissue engineering, regenerative medicine, biomedicine. The discusses their role enhancing mechanical properties, mimicking extracellular matrix, incorporating hydrophobic particles self-healing abilities, improving stability. Additionally, it explores antibacterial optical sensing applications, cancer therapy, wound healing. emphasizes significance expanding addressing healthcare challenges, outcomes. By highlighting these achievements, this highlights transformative impact engineering sets stage further research development field.

Язык: Английский

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High-sensitivity and ultralow-hysteresis fluorine-rich ionogel strain sensors for multi-environment contact and contactless sensing

Materials Horizons, Год журнала: 2023, Номер 10(12), С. 5907 - 5919

Опубликована: Янв. 1, 2023

Information transduction via soft strain sensors under harsh conditions such as marine, oily liquid, vacuum, and extreme temperatures without excess encapsulation facilitates modern scientific military exploration. However, most reported struggle to meet these requirements, especially in complex environments. Herein, a class of fluorine-rich ionogels with tunable ultimate strain, high conductivity, multi-environment tolerance are designed. Abundant ion-dipole dipole-dipole interactions lead excellent miscibility between the hydrophobic ionic liquid fluorinated polyacrylate matrix, well adhesion diverse substrates amphibious The ionogel-based sensors, even encapsulation-free form, exhibit stable operation negligible hysteresis (as low 0.119%) sensitivity (gauge factor up 6.54) conditions. Multi-environment sensing instances contact contactless forms also demonstrated. This study opens door for artificial syntheses skins robust applications electronics robotics.

Язык: Английский

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