Abstract
Diabetic
wounds
pose
a
persistent
challenge
due
to
their
slow
healing
nature,
primarily
caused
by
bacterial
infection
and
excessive
reactive
oxygen
species
(ROS)‐induced
inflammation.
In
this
study,
carbon
dots
with
synergistic
antibacterial
antioxidant
properties,
referred
as
AA‐CDs,
are
developed
specifically
for
diabetic
wound
using
straightforward
solvothermal
method.
By
utilizing
cost‐effective
precursors
like
citric
acid
ascorbic
acid,
AA‐CDs
engineered
possess
tailored
functions
of
photothermal
sterilization
ROS
scavenging.
The
resulting
demonstrats
broad‐spectrum
activity,
particularly
against
multidrug‐resistant
strains,
along
efficient
scavenging
both
in
solution
within
cells.
Additionally,
exhibits
protective
effect
oxidative
stress‐induced
damage.
Notably,
high
conversion
efficiency
(41.18%),
displays
heat‐enhanced
performance,
providing
not
only
augmented
but
also
additional
protection
stress,
yielding
true
“1
+
1
>
2”
effect.
To
facilitate
use
vivo,
incorporated
into
thermally
responsive
hydrogel,
which
evident
anti‐inflammatory
properties
modulating
inflammatory
factors
significantly
promots
the
wounds.
This
study
underscores
value
integrated
platforms
highlights
potential
versatile
CDs
promising
therapeutic
agents
biomedical
applications.
Journal of Nanoparticle Research,
Год журнала:
2025,
Номер
27(2)
Опубликована: Янв. 31, 2025
Abstract
Carbon
dots
represent
a
rapidly
advancing
and
expanding
research
field,
with
large
number
of
literature
reports
on
their
potential
technological
applications
including
those
relevant
to
food
safety.
In
this
article,
the
dot
samples
prepared
by
deliberate
chemical
functionalization
preexisting
small
carbon
nanoparticles
or
thermal
carbonization
various
organic
precursors
under
different
processing
conditions
are
highlighted
critiqued
for
similarities
differences
in
sample
structure-morphology
properties,
especially
antimicrobial
properties
safety–related
uses.
Also
discussed
representative
recent
examples
use
inactivate
foodborne
pathogens,
disrupt
biofilms
prevent
formation,
extend
shelf
life
products,
which
involve
antibacterial
mechanisms.
Some
perspectives
further
development
dots–based/derived
platform
related
excellent
application
opportunities
safety
provided.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101553 - 101553
Опубликована: Фев. 5, 2025
Wounds
infected
by
bacteria
pose
a
considerable
challenge
in
the
field
of
healthcare,
particularly
with
increasing
prevalence
antibiotic-resistant
pathogens.
Traditional
antibiotics
often
fail
to
achieve
effective
results
due
limited
penetration,
resistance
development,
and
inadequate
local
concentration
at
wound
sites.
These
limitations
necessitate
exploration
alternative
strategies
that
can
overcome
drawbacks
conventional
therapies.
Nanomaterials
have
emerged
as
promising
solution
for
tackling
bacterial
infections
facilitating
healing,
thanks
their
distinct
physicochemical
characteristics
multifunctional
capabilities.
This
review
highlights
latest
developments
nanomaterials
demonstrated
enhanced
antibacterial
efficacy
improved
healing
outcomes.
The
mechanisms
are
varied,
including
ion
release,
chemodynamic
therapy,
photothermal/photodynamic
electrostatic
interactions,
delivery
drugs,
which
not
only
combat
but
also
address
challenges
posed
biofilms
antibiotic
resistance.
Furthermore,
these
create
an
optimal
environment
tissue
regeneration,
promoting
faster
closure.
By
leveraging
unique
attributes
nanomaterials,
there
is
significant
opportunity
revolutionize
management
wounds
markedly
improve
patient
Abstract
The
global
pandemic
and
excessive
use
of
antibiotics
have
raised
concerns
about
environmental
health,
efforts
are
being
made
to
develop
alternative
bactericidal
agents
for
disinfection.
Metal‐based
nanomaterials
their
derivatives
emerged
as
promising
candidates
antibacterial
due
broad‐spectrum
activity,
friendliness,
excellent
biocompatibility.
However,
the
reported
mechanisms
these
materials
complex
lack
a
comprehensive
understanding
from
coherent
perspective.
To
address
this
issue,
new
perspective
is
proposed
in
review
demonstrate
toxic
activities
metal‐based
terms
energy
conversion
electron
transfer.
First,
antimicrobial
different
discussed,
advanced
research
progresses
summarized.
Then,
biological
intelligence
applications
materials,
such
biomedical
implants,
stimuli‐responsive
electronic
devices,
monitoring,
concluded
based
on
trappable
electrical
signals
Finally,
current
improvement
strategies,
future
challenges,
possible
resolutions
outlined
provide
insights
into
behaviors
offer
valuable
inspiration
instructional
suggestions
building
intelligent
health.
