Опубликована: Янв. 1, 2024
Язык: Английский
Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 519 - 534
Опубликована: Янв. 11, 2024
Язык: Английский
Процитировано
37
Journal of Controlled Release, Год журнала: 2024, Номер 367, С. 366 - 384
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
17
Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(9)
Опубликована: Сен. 1, 2024
Abstract Graphene quantum dots (GQDs), owing to their unique optical, electrical, and chemical properties, have emerged as promising nanomaterials for various biomedical applications. This review provides a comprehensive overview of the latest advancements in utilization GQDs tissue engineering, wound healing, drug delivery systems, other therapies. The inherent properties GQDs, including high biocompatibility, tunable photoluminescence, significant surface area, make them ideal candidates enhancing medical treatments diagnostics. In improve mechanical biological performance scaffolds, promoting cell proliferation differentiation. For enhance antimicrobial activity facilitate faster regeneration. Their potential DDS is highlighted by ability deliver therapeutic agents efficiently, ensuring targeted controlled release. Additionally, play crucial role therapies, particularly cancer treatment, efficacy reducing side effects. While offer diagnostics, challenges such understanding long‐term cytotoxicity at higher concentrations, need standardized synthesis methods remain critical areas further research. also discusses future directions opportunities emphasizing transformative advancing modern healthcare solutions. insights presented here contribute expanding field GQD research, highlighting significantly patient outcomes drive innovations.
Язык: Английский
Процитировано
11
Cells, Год журнала: 2024, Номер 13(10), С. 789 - 789
Опубликована: Май 7, 2024
Modern medicine has allowed for many advances in neurological and neurodegenerative disease (ND). However, the number of patients suffering from brain diseases is ever increasing treatment remains an issue, as drug efficacy dramatically reduced due to existence unique vascular structure, namely blood–brain barrier (BBB). Several approaches enhance delivery have been investigated but proven be unsuccessful limited transport or damage induced BBB. Alternative molecular revealed recent studies through pathways that regulate passage peripheral molecules. In this review, we present advancements basic research these well examples promising ventures overcome hurdles will therapeutic interventions potentially save lives millions patients.
Язык: Английский
Процитировано
8
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106623 - 106623
Опубликована: Янв. 1, 2025
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)
Опубликована: Март 21, 2024
Alzheimer's disease (AD) is a chronic, insidious, and progressive neurodegenerative that remains clinical challenge for society. The fully approved drug lecanemab exhibits the prospect of therapy against pathological processes, while debatable adverse events conflict with concentration required anticipated therapeutic effects. Reactive oxygen species (ROS) are involved in progression AD, as has been demonstrated much research regarding oxidative stress (OS). contradiction between dosage event may be resolved through targeted transport by biomaterials get effects via regulation ROS. Besides, fix delivery issues promoting penetration drugs across blood-brain barrier (BBB), protecting from peripheral degradation, elevating bioavailability. goal to comprehensively understand mechanisms ROS AD potential ROS-related treatment AD. This review focuses on OS its connection novel recent years inspire biomaterial development. Revisiting these associated thorough investigations presents considerable bright future improving effective interventions
Язык: Английский
Процитировано
7
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134962 - 134962
Опубликована: Авг. 22, 2024
Язык: Английский
Процитировано
6
Alcohol, Год журнала: 2024, Номер 117, С. 27 - 41
Опубликована: Март 18, 2024
Язык: Английский
Процитировано
5
Nanoscale Horizons, Год журнала: 2024, Номер 9(11), С. 1855 - 1895
Опубликована: Янв. 1, 2024
Chiral graphene, a “superlattice structure,” effectively engages with target substances. Its superconductivity, tunable electronic structure, and topological states could significantly contribute to advanced materials science technologies.
Язык: Английский
Процитировано
4
Heliyon, Год журнала: 2025, Номер 11(3), С. e42412 - e42412
Опубликована: Фев. 1, 2025
Alzheimer's disease (AD) is a progressive condition marked by multiple underlying mechanisms. Therefore, the investigation of natural products that can target pathways presents potential gate for understanding and management AD. This study aimed to assess neuroprotective effects hydroalcoholic extract Dracocephalum moldavica (DM) on cognitive impairment, biomarker changes, putative metabolic in rat model AD induced intracerebroventricular streptozotocin (ICV-STZ). The DM was standardized quantified based examining total phenolic, flavonoid, rosmarinic acid, quercetin contents using colorimetry high-performance liquid chromatography (HPLC) methods. antioxidant evaluated 2,2-Diphenyl-1-picrylhydrazyl nitric oxide radical scavenging assays. Male Wistar rats were injected with STZ (3 mg/kg, single dose, bilateral ICV) induce sporadic (sAD) model. Following induction, orally administered (100, 200, 400 mg/kg/day) or donepezil (5 21 days. Cognitive function assessed radial arm water maze behavioral test. histopathological evaluations conducted cortex hippocampus regions. Matrix-assisted laser desorption/ionization-time flight mass spectrometry (MALDI-TOF MS) used metabolite changes various brain significantly attenuated dysfunction ICV-STZ according investigations. Thirty-two discriminating metabolites related amino acid metabolism; glutamate/gamma-aminobutyric acid/glutamine cycle; nucleotide lipid metabolism (glycerophospholipids, sphingomyelins, ceramides, phosphatidylserines, prostaglandins), glucose identified brains sAD simultaneously first time this Polyphenols may contribute regulation these pathways. After treatment extract, 10 from 32 ones altered tissue sAD, most commonly at doses 200 mg/kg. In conclusion, demonstrates upregulation/downregulation pathophysiological biomarkers such as adenine, glycerophosphoglycerol, inosine, prostaglandins, sphingomyelin sAD. These findings are consistent results outcomes.
Язык: Английский
Процитировано
0