Recent Applications of PLGA in Drug Delivery Systems

Polymers, Год журнала: 2024, Номер 16(18), С. 2606 - 2606

Опубликована: Сен. 14, 2024

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, end caps, that significantly influence release profiles degradation times. This review also covers extensive literature on application PLGA delivering small-molecule drugs, proteins, peptides, antibiotics, antiviral drugs. Furthermore, discuss role PLGA-based DDSs treating various diseases, cancer, neurological disorders, pain, inflammation. The incorporation drugs into nanoparticles microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, improve patient compliance. Overall, holds great promise for advancement treatment management multiple chronic conditions.

Язык: Английский

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Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 104 - 104

Опубликована: Янв. 15, 2025

Cytokine-mediated inflammation is increasingly recognized for playing a vital role in the pathophysiology of wide range brain disorders, including neurodegenerative, psychiatric, and neurodevelopmental problems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) cause neuroinflammation, alter function, accelerate disease development. Despite progress understanding these pathways, effective medicines targeting are still limited. Traditional anti-inflammatory immunomodulatory drugs peripheral inflammatory illnesses. Still, they face substantial hurdles when applied to central nervous system (CNS), blood-brain barrier (BBB) unwanted systemic effects. This review highlights developing treatment techniques modifying cytokine-driven focusing on advances that selectively target critical involved pathology. Novel approaches, cytokine-specific inhibitors, antibody-based therapeutics, gene- RNA-based interventions, sophisticated drug delivery systems like nanoparticles, show promise with respect lowering neuroinflammation greater specificity safety. Furthermore, developments biomarker discoveries neuroimaging improving our ability monitor responses, allowing more accurate personalized regimens. Preclinical clinical trial data demonstrate therapeutic potential tailored techniques. However, significant challenges remain, across BBB reducing off-target As research advances, creation personalized, cytokine-centered therapeutics has therapy landscape illnesses, giving patients hope better results higher quality life.

Язык: Английский

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Potent antitumor effect of intranasally administrable pH-sensitive and photothermal polymeric oncolytic adenovirus for the treatment of brain cancer

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159770 - 159770

Опубликована: Янв. 1, 2025

Язык: Английский

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Bringing intranasal drug delivery for malignancies in the brain to market

Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Keywords: Blood-brain barrierbrain cancergliomameningiomaNEO100nose-to-brain pathwayperillyl alcoholtemozolomide

Язык: Английский

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Design and synthesis of drug hydrogels containing carboxymethylcellulose with honeycomb structure and pH-sensitivity as drug delivery systems for adriamycin, metformin, and naproxen

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 271, С. 132568 - 132568

Опубликована: Май 21, 2024

Язык: Английский

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A brain-targeted and ROS-responsive natural polysaccharide nanogel for enhancing antidepressant therapy

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160719 - 160719

Опубликована: Фев. 1, 2025

Язык: Английский

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Therapeutic drug delivery system for ischemic heart disease based on hydrogel carriers

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106782 - 106782

Опубликована: Март 1, 2025

Язык: Английский

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Uniform Spray Dried Loxapine Microparticles Potentially for Nasal Delivery: Exploring Discriminatory In Vitro Release Evaluation Methods

The AAPS Journal, Год журнала: 2025, Номер 27(2)

Опубликована: Март 12, 2025

Язык: Английский

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Intranasal pramlintide matches intraperitoneal effects on food intake and gastric emptying in mice

Endocrine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Язык: Английский

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Lessons Learned from the COVID-19 Pandemic: The Intranasal Administration as a route for treatment – A Patent Review

Pharmaceutical Development and Technology, Год журнала: 2025, Номер unknown, С. 1 - 33

Опубликована: Апрель 5, 2025

The COVID-19 pandemic exposed the fragility of today's marketed treatments for respiratory infections. As a primary site infection, upper airways may represent key access route control and treatment these conditions. present study aims to explore identify, through patent review, novelty therapies that use intranasal drug administration. A search was carried out in Wipo Espacenet, using descriptors "COVID-19 OR SARS-CoV 2" AND "treatment therapy" NOT "vaccine immunizing" classification "A61K9/0043". Of 151 patents identified, we excluded 73 duplicates, 36 documents meet criteria adopted exclusion (not nasally administered formulations, vaccines, post treatments, uncertain administration or form). We identified 78 unique on databases, which 42 were selected this review. revealed pathway not only repositioning but also plant-derived biological molecules. Overall, new formulations variety known drugs natural products incorporated carrier systems devices delivery Thus, remains promising strategy delivery, offering direct infection warranting further exploration.

Язык: Английский

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