Опубликована: Янв. 1, 2024
Язык: Английский
RSC Advances, Год журнала: 2025, Номер 15(6), С. 4031 - 4078
Опубликована: Янв. 1, 2025
Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective disease-modifying treatments.
Язык: Английский
Процитировано
0
Molecular Brain, Год журнала: 2025, Номер 18(1)
Опубликована: Март 3, 2025
Following intracerebral hemorrhage, mitigating oxidative stress and removing excess iron are critical strategies for reducing secondary brain injury improving neurological outcomes. In vitro, we synthesized quercetin-ethylenediamine carbon quantum dots (QECQDs) with diameters of 2-11 nm found that QECQDs effectively scavenge ABTS+· DPPH· free radicals, defending HT22 cells against hemin-induced stress. vivo, predominantly accumulate in the pia mater, subarachnoid space, dura mater after intrathecal injection. Compared to ICH group, treatment improves cerebral blood flow, inhibits damage, reduces neuron death. Importantly, reduced hemorrhage volume, alleviated edema, improved function. This lays a foundation developing multi-target drugs treating ICH.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161784 - 161784
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125584 - 125584
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 19, 2024
Alzheimer's disease (AD) is a common neurodegenerative characterized by progressive cognitive and physical impairment. Neuroinflammation related to AD, the misfolding aggregation of amyloid protein in brain creates an inflammatory microenvironment. Microglia are predominant contributors neuroinflammation, abnormal activation microglia induces release large amount factors, promotes neuronal apoptosis, leads In this study, we used microglial membranes containing caffeic acid-coupled carbon quantum dots prepare novel biomimetic nanocapsule (CDs-CA-MGs) for treatment AD. The application CDs-CA-MGs via nasal administration can bypass blood‒brain barrier (BBB) directly target site inflammation. After with CDs-CA-MGs, AD mice showed reduced inflammation brain, decreased significantly improved learning memory abilities. addition, affect inflammation-related JAK-STAT Toll-like receptor signaling pathways mice. downregulated interleukins (IL-1β IL-6) tumor necrosis factor (TNF-α). This finding suggested that may improve impairment modulating responses. conclusion, use provides possible therapeutic strategy
Язык: Английский
Процитировано
3
Clinical and Translational Discovery, Год журнала: 2023, Номер 3(6)
Опубликована: Ноя. 15, 2023
Abstract In order to overcome the formidable challenges posed by intricate physiological barriers of brain, employment intranasal administration (INA) has emerged as an unconventional method for drug delivery, offering distinct advantages such non‐invasiveness and enhanced pharmacokinetic characteristics within brain. Primarily exploiting conduit offered olfactory and/or trigeminal nerve systems, INA route effectively delivers therapeutic agents. With introducing appropriate improvements formulation, incorporation nanocarriers, efficacious delivery via approach gained considerable traction treatment neurological disorders. This concise review highlights notable progress in explores potential modalities inherent this promising paradigm.
Язык: Английский
Процитировано
8
Materials Horizons, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder marked by permanent impairment of brain function across the whole brain. This condition results in deterioration cognitive patients and frequently associated with psychological symptoms such as agitation anxiety, imposing significant burden on both their families. Nanomaterials possess numerous distinctive physical chemical features that render them extensively utilized. In biomedical domain, nanomaterials can be utilized for prevention therapy, including medication delivery systems, biosensors, tissue engineering. article explores etiology potential molecular processes AD, well application carbon-based diagnosis treatment AD. Some are carbon quantum dots, nanotubes, graphene, among others. These materials physicochemical highly promising applications biosensing, drug delivery, neuroprotection, photothermal treatment. addition, this review explored various therapeutic approaches AD terms reducing inflammation, preventing oxidative damage, inhibiting Aβ aggregation. The advent nanotechnology has facilitated development novel disease. strategies provide early diagnosis, effective intervention neuroprotection
Язык: Английский
Процитировано
2
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 91, С. 105265 - 105265
Опубликована: Дек. 16, 2023
Язык: Английский
Процитировано
6
The Journal of Physical Chemistry B, Год журнала: 2024, Номер 128(30), С. 7427 - 7437
Опубликована: Июль 18, 2024
The current study explores the synergistic application of biophysical chemistry and nanotechnology in therapeutic treatments, focusing specifically on development advanced biomaterials to repurpose FDA-approved Alzheimer's disease (AD) drugs as potent antioxidants. By integration AD into graphene oxide (GO) nanocomposites, an attempt enhance acetylcholinesterase (AChE) inhibition increase radical scavenging activity is proposed. This bionano synergy designed leverage unique properties both nanomaterial surface bioactive compounds, improving treatment effectiveness. nanocomposites also promise targeted drug delivery, GO can traverse blood-brain barrier inhibit AChE more effectively patients. Furthermore, drug-GO nanocomposite exhibits enhanced capabilities, offering additional benefits. elucidates a molecular level understanding how are modified when integrated with GO, enabling effective materials. interdisciplinary approach presented this exploits potential delivery systems achieve superior outcomes through synergy.
Язык: Английский
Процитировано
1