Chemical Science, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Modulation of coordination configuration is crucial for boosting the biomimetic catalytic activity nanozymes, but remains challenging. Here, we found that non-first-shell amino group in ligand was capable steering N/S number through remote induction to enable formation a low-coordinated CuN
Язык: Английский
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 178, С. 117862 - 117862
Опубликована: Июль 10, 2024
Язык: Английский
Процитировано
19
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Язык: Английский
Процитировано
3
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Дек. 30, 2024
Metal–organic frameworks (MOFs) have emerged as innovative nanozyme mimics, particularly in the area of oxidase catalysis, outperforming traditional MOF-based peroxidase and other nanomaterial-based systems. This review explores various advantages that MOFs offer terms catalytic activity, low-cost, stability, structural versatility. With a primary focus on their application biochemical sensing, oxidases demonstrated remarkable utility, prompting thorough exploration design modification strategies. Moreover, aims to provide comprehensive analysis strategies employed rational MOF structures optimize key parameters such sensitivity, selectivity, stability context sensors. Through an exhaustive examination recent research developments, this article seeks insights into nuanced interplay between performance, shedding light mechanisms underpin effectiveness mimics. Finally, addresses challenges opportunities associated with aiming drive further advancements structure development highly effective sensors for diverse applications.
Язык: Английский
Процитировано
9
Small Structures, Год журнала: 2024, Номер 5(7)
Опубликована: Апрель 26, 2024
Nanozymes, nanomaterials exhibiting enzyme‐mimicking activities, have gained considerable interest in biomedicine due to their stability, adjustability, and cost‐efficiency. Among these, metal–organic framework (MOF)‐based nanozymes distinguish themselves by distinct structure customizable characteristics. Researchers explored MOF‐based as a platform for developing stimuli‐responsive behaviors. This work first presents the categorization of nanozymes, which are designed mimic catalytic functions oxidases, peroxidases, catalase, superoxide dismutase, hydrolases, multifunctional enzymes. Crafting includes customizing reactions particular stimuli, including pH, temperature, light, or biomolecular triggers, ensuring enhanced specificity potency performance amid environmental changes. Moreover, these exhibit immense potential biomedical applications, playing crucial roles therapeutic interventions like cancer therapy tissue regeneration. Finally, article delves into future opportunities challenges within emerging research frontiers. These offer novel avenues advanced strategies, providing prospects innovative applications.
Язык: Английский
Процитировано
6
Analytical Chemistry, Год журнала: 2024, Номер 96(37), С. 14944 - 14952
Опубликована: Авг. 29, 2024
The long-term operation feature of enzymatic biofuel cell-based self-powered biosensor (EBFC-SPB) endows them with the potential to execute dual-signal biosensing without having integrate an extra signal acquisition device. Herein, cobalt and manganese codoped CeO2 nanospheres (CoMn-CeO2 NSs) glucose-oxidase-like peroxidase-like activities have been developed as substrate-switched dual-channel transduction components in EBFC-SPB for a assay aflatoxin B1 (AFB1). CoMn-CeO2 NSs modified aptamer are anchored complementary DNA-attached bioanode by base pairing, which catalyze glucose oxidation together oxidase (GOx) on bioanode. Once AFB1 appears, will be released from due binding specificity aptamer, resulting decreased catalytic efficiency first declining stage EBFC-SPB. Accompanied introduction H2O2, residual switch activity mediate production benzo-4-chlorohexadienone (4-CD) precipitate, increases steric hindrance yields another By assessing variation amplitudes during these two stages, has realized satisfying results. This work not only breaks ground bioassays but also deepens application nanozymes
Язык: Английский
Процитировано
4
Microchemical Journal, Год журнала: 2025, Номер 209, С. 112661 - 112661
Опубликована: Янв. 4, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141346 - 141346
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Abstract Mimicking the structure of natural enzyme active sites offers a promising strategy for rational design nanozymes. However, this biomimetic approach predominantly focuses on replicating configuration metal center in enzymes, often overlooking critical influence catalytic site's microenvironment. Here, inspired by and coordination microenvironment organophosphorus hydrolase (OPH), Ce 2 O CN /NC, novel cerium‐based nanozyme is first reported to mimic OPH. In species serve as sites, while adjacent N site ([N═C═N] 2− ) functions general base, mimicking histidine enzymes facilitate hydrolysis process. Using paraoxon model target, /NC demonstrates rapid dephosphorylation phosphotriester across wide range temperatures pH values, significantly outperforming OPH CeO nanoparticles. The systematic experiments theoretical calculations reveal underlying mechanisms responsible enhanced OPH‐mimicking performance. Capitalizing its phosphatase‐like activity, successfully employed develop colorimetric biosensor selective detection pesticides. This study holds great promise developing efficient nanozymes broadens Ce‐based
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Язык: Английский
Процитировано
0