Expanded ROS Generation and Hypoxia Reversal: Excipient‐free Self‐assembled Nanotheranostics for Enhanced Cancer Photodynamic Immunotherapy
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 12, 2024
The
efficacy
of
photodynamic
therapy
(PDT)-related
cancer
therapies
is
significantly
restricted
by
two
irreconcilable
obstacles,
i.e.,
low
reactive
oxygen
species
(ROS)
generation
capability
and
hypoxia
which
constrains
the
immune
response.
Herein,
this
work
develops
a
self-assembled
clinical
photosensitizer
indocyanine
green
(ICG)
HSP90
inhibitor
17-dimethylaminoethylamino-17-demethoxygeldanamycin
(17-DMAG)
nanoparticles
(ISDN)
without
any
excipient.
This
discovers
that
hydrophobic
interaction
forces
between
ICG
17-DMAG
promote
photostability
its
intersystem
crossing
(ISC)
process,
thereby
improving
ROS
quantum
yield
from
0.112
to
0.46.
Augmented
enhances
PDT
further
immunogenic
cell
death
(ICD)
effects.
inhibits
HSP90/hypoxia-inducible
factor
1α
(HIF-1α)
axis
dramatically
reverse
immunosuppressive
tumor
microenvironment
caused
PDT-aggravated
hypoxia.
In
mouse
model
pancreatic
cancer,
ISDN
markedly
improve
cytotoxic
T
lymphocyte
infiltration
MHC
I
II
activation,
demonstrating
superior
ICD
effects
in
situ
powerful
systematic
antitumor
immunity
generation,
eventually
achieving
vigorous
recurrence
resistance.
study
proposes
an
unsophisticated
versatile
strategy
for
enhancing
systemic
potentially
extending
it
multiple
cancers.
Язык: Английский
Biomimetic MOF‐Based Nano‐Immunoactivator via Disruption of Ion Homeostasis for Strengthened Tumor Microwave‐Immunotherapy
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Март 4, 2024
Abstract
Immunogenic
cell
death
(ICD)
is
a
promising
strategy
for
anticancer
immunity
by
inducing
antigen‐presenting
maturation.
However,
the
traditional
ICD
inducers,
such
as
chemotherapeutic
agents,
have
largely
hampered
their
application
severe
side
effects
and
low
tumor
selectivity.
The
changes
intra/extracellular
ion
concentrations
affect
growth
metastasis
of
cells.
Interference
with
homeostasis
can
induce
elicit
immune
responses.
Here,
biomimetic
Ga‐based
metal–organic
framework
(MOF)
coated
red
blood
cell–platelet
fusion
membrane
(RPM),
that
is,
5‐fluorouracil@GaMOF@RPM
(5‐FUGR)
nano‐immunoactivator,
reported
highly
efficient
inducer
enhanced
microwave
(MW)‐immunotherapy.
Following
intravenous
administration,
5‐FUGR
accumulates
to
site
via
RPM
modification‐mediated
long
circulation
active
targeting.
structure
undergoes
degradation
releases
Ga
3+
.
MW
combined
high
disrupts
intracellular
homeostasis,
which
leads
oxidative
stress
Ca
2+
retention
promote
apoptosis
More
importantly,
not
only
completely
eradicates
4T1
primary
tumors,
but
also
induces
ICD,
initiation,
memory
inhibit
metastatic
recurrence
tumor.
Thus,
5‐FUGR,
strong
inducer,
provides
new
insights
into
achieving
in
combination
other
therapies.
Язык: Английский
Dual-upregulation of p53 for self-sensitized cuproptosis via microwave dynamic and NO gas therapy
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
unknown, С. 137421 - 137421
Опубликована: Март 1, 2025
Язык: Английский
Gold Nanostars and Nanourchins for Enhanced Photothermal Therapy, Bioimaging, and Theranostics
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Photothermal
therapy
(PTT),
a
recently
emerging
method
for
eradicating
tumors,
utilizes
hyperthermia
induced
by
photo-absorbing
materials
to
generate
heat
within
cancer
cells.
Gold
nanoparticles
(AuNPs)
have
gained
reliability
Язык: Английский
Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation
Rare Metals,
Год журнала:
2024,
Номер
43(10), С. 5186 - 5201
Опубликована: Июнь 18, 2024
Язык: Английский
Bioinspired Hf-based metal-organic framework radiosensitizer for nitric oxide-assisted radio-immunotherapy
Nano Today,
Год журнала:
2024,
Номер
58, С. 102447 - 102447
Опубликована: Авг. 17, 2024
Язык: Английский
Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
The
oxygen
consumption
during
chemodynamic
therapy
(CDT)
can
lead
to
severe
cellular
hypoxia,
resulting
in
an
increase
the
hypoxia
inducible
factor-1α
(HIF-1α)
level,
which
hinders
effectiveness
of
CDT
and
induces
tumor
metastasis.
Here,
we
propose
a
strategy
synergistic
between
HIF-1α
inhibitor
avoid
limitations
reduce
risk
Herein,
based
on
coordination
Fe3+
apigenin
(API,
inhibitor),
constructed
hyaluronic
acid
(HA)-modified
API-Fe
nanoparticles
(AF@HA
NPs)
for
synergetic
chemotherapy
glutathione
(GSH)-activated
self-enhancing
CDT.
AF@HA
NPs
have
high
drug
loading
capacity,
stability,
biocompatibility.
Furthermore,
overexpressed
GSH
cancer
cells
Fe2+,
weakened
API
Fe,
promoted
release
chemotherapy.
Fe2+
could
react
with
endogenous
H2O2
generate
hydroxyl
groups
In
addition,
released
inhibit
expression
sensitivity
reactive
species
(ROS),
thereby
achieving
effect
results
vitro
vivo
experiments
indicated
that
effectively
growth
suppress
lung
metastasis
cells.
Язык: Английский