Advances in photocrosslinked natural hydrogel‐based microspheres for bone repair

Journal of Polymer Science, Год журнала: 2024, Номер 62(22), С. 4966 - 4992

Опубликована: Авг. 9, 2024

Abstract In recent years, the prevalence of bone diseases is showing an increasing trend, which mainly attributed to aging global population. However, repair and regeneration are still unsolved problem in treatment diseases, include a series biological events. Photocrosslinked natural hydrogel‐based microspheres (PNHMs) spherical particles composed photocrosslinked hydrogel components. Due their morphology, injectability, biocompatibility, PNHMs widely used tissue regeneration, particularly for defects. this article, we review available materials PNHMs, then introduce preparation methods. After that, summarize important advanced functionalities PNHMs. For example, can be loaded with different active ingredients exert anti‐inflammatory, antibacterial, antioxidant effects, while also realizing lubrication due specific shape size distribution. addition, function capturing ions realized via coordination. When applied engineering, promote angiogenesis osteogenesis, great potential diseases. Finally, challenges prospects discussed.

Язык: Английский

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Phenylboronic-tannin nanocolloids that scavenge subchondral reactive oxygen microenvironment and inhibit RANKL induced osteoclastogenesis for osteoarthritis treatment

Nano Research, Год журнала: 2024, Номер 17(11), С. 9898 - 9907

Опубликована: Авг. 13, 2024

Язык: Английский

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Enzyme-responsive microgel with controlled drug release, lubrication and adhesion capability for osteoarthritis attenuation

Acta Biomaterialia, Год журнала: 2024, Номер 190, С. 191 - 204

Опубликована: Окт. 18, 2024

Язык: Английский

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Recent advancements in microspheres mediated targeted delivery for therapeutic interventions in osteoarthritis

Journal of Microencapsulation, Год журнала: 2024, Номер 41(6), С. 434 - 455

Опубликована: Июль 5, 2024

Osteoarthritis (OA), affecting around 240 million people globally is a major threat. Currently, available drugs only treat the symptoms of OA; they cannot reverse disease's progression. The delivery to afflicted joints challenging because poor vasculature articular cartilage results in their less bioavailability and quick elimination from joints. Recently approved such as KGN IL-1 receptor antagonists also encounter challenges inadequate formulations. Therefore, microspheres could be potential player for intervention OA owing its excellent physicochemical properties. This review primarily focuses on distinct biomaterials acting cargo biologicals via different routes effective management OA. Microspheres can improve efficacy therapeutics by targeting strategies at specific body locations. highlights clinical trials conducted last few decades.

Язык: Английский

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Injectable hydrogel microsphere-bomb for MRSA-infected chronic osteomyelitis

Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 337 - 353

Опубликована: Окт. 18, 2024

Язык: Английский

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