A tandem-unlocked cascade nanoreactor for high-contrast magnetic resonance imaging-guided enhanced ferroptosis-chemo synergistic therapy

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101852 - 101852

Опубликована: Май 1, 2025

Язык: Английский

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Ultra-small copper oxide with peroxidase-like activity for colorimetric detection of doxorubicin in chicken and fish

Journal of Food Composition and Analysis, Год журнала: 2024, Номер 132, С. 106282 - 106282

Опубликована: Апрель 26, 2024

Язык: Английский

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Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

Journal of Medicinal Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 30, 2024

Innovative strategies for targeted anticancer therapies have gained significant momentum, with metal complexes emerging as tunable catalysts more effective and safer treatments. Rational design engineering of enable the development tailored molecular structures optimized precision oncology. The strategic incorporation complex within combinatorial amplifies their properties. This perspective highlights advancements in synthetic rational since 2019, showing how are by designing to release or

Язык: Английский

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A metal-organic framework functionalized CaO2-based cascade nanoreactor induces synergistic cuproptosis/ferroptosis and Ca2+ overload-mediated mitochondrial damage for enhanced sono-chemodynamic immunotherapy

Acta Biomaterialia, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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Bioengineering stimuli-responsive organic-inorganic nanoarchitetures based on carboxymethylcellulose-poly-l-lysine nanoplexes: Unlocking the potential for bioimaging and multimodal chemodynamic-magnetothermal therapy of brain cancer cells

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 290, С. 138985 - 138985

Опубликована: Дек. 19, 2024

Язык: Английский

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Topological structures and adsorption properties of the [Fe4S4] clusters

Physica Scripta, Год журнала: 2024, Номер 99(8), С. 085413 - 085413

Опубликована: Июль 22, 2024

Abstract The [Fe 4 S ] compositions are ubiquitous in biological systems as integral parts of the complex catalytic mechanisms hydrogenases and nitrogenases. current reports about species based on cube-like structure framework. Here, topological structures, stability electronic properties gas phase + , 0 − analyzed. It is found that ground state structures these three clusters have similar cubic cages but different symmetries spin multiplicities. molecular dynamics simulations demonstrate cage remains thermodynamically stable at 700 K. density states show charge key to affect behaviors them even under same structural orbitals LUMO distributed throughout whole showing great delocalized characteristics, especially for anionic while HOMO orbits mainly localized Fe-S bonds, which also confirmed by electron localization function analyses. After one CO molecule adsorbed clusters, it prefers locate Fe atoms. Moreover, C–O bond length vibration frequency -CO undergone a significant red shift. Our work shows may act potential catalyst activating bond.

Язык: Английский

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Cytotoxicity assessment of Cu0.5Zn0.5Fe2O4 nanoparticles prepared via rapid combustion-calcination process on SGC-7901 and HGC-27 gastric cancer cells

Materials Today Communications, Год журнала: 2024, Номер 40, С. 110098 - 110098

Опубликована: Авг. 1, 2024

Язык: Английский

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In situ supramolecular self-assembly of a perylene diimide derivative in mitochondria for cancer cell ferroptosis

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(21), С. 6055 - 6063

Опубликована: Янв. 1, 2024

An in situ supramolecular self-assembly system that could lead to the ferroptosis of cancer cells was successfully constructed mitochondria.

Язык: Английский

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Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+ T cells for triple-negative breast cancer therapy

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер unknown, С. 100970 - 100970

Опубликована: Окт. 1, 2024

Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of antioxidant system resulting from iron accumulation in triple-negative breast cancer (TNBC) therapy. However, ferroptosis accompanied with down-regulation glutathione peroxidase 4 (GPX4) lead to CD36-mediated tumor-infiltrating CD8+ T cells uptaking fatty acids, negative action on immunotherapeutic efficacy. Herein, albumin nanoparticles, abbreviated LHS NPs, were designed by co-assembly hemin, linoleic acid-cystamine, CD36 inhibitor sulfosuccinimide oleate, bi-directionally manipulated tumor TNBC NPs exerted more efficient reactive oxygen species generation, depletion malondialdehyde production combinatory classical non-classical modes, which amplified positive cells. Meanwhile, inhibiting mediated-lipid cells, thereby activating efficacy improvements induction immunogenic death, proliferation CD4+CD8+ natural killer alleviation immunosuppressive regulatory myeloid-derived suppressor repolarization M2- M1-phenotype tumor-associated macrophages. Thus, demonstrated an improved antitumor suppressing growth lung metastasis 4T1-tumor mice. Our work gives novel insights manipulating chemoimmunotherapy.

Язык: Английский

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Glucose oxidase-driven self-accelerating drug release nanosystem based on metal-phenolic networks orchestrates tumor chemotherapy and ferroptosis-based therapy

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139103 - 139103

Опубликована: Дек. 1, 2024

Язык: Английский

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