Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101553 - 101553

Опубликована: Фев. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Язык: Английский

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Reactive Oxygen Species-Responsive Pillararene-Embedded Covalent Organic Frameworks with Amplified Antimicrobial Photodynamic Therapy for the Targeted Elimination of Periodontitis Pathogens

Nano Letters, Год журнала: 2024, Номер 24(43), С. 13708 - 13717

Опубликована: Окт. 17, 2024

Reactive oxygen species (ROS)-responsive drug delivery systems possess immense potential for targeted and controlled release of therapeutics. However, the rapid responsiveness to ROS sustained antibacterial drugs are often limited by challenging microenvironment periodontitis. Integrating ROS-responsive with photocatalytic technologies presents a strategic approach overcome these limitations. Herein, pillararene-embedded covalent organic framework (PCOF) incorporating prodrug thioacetal (TA) has been developed treat This drug-loaded nanoplatform, namely TA-loaded PCOF, utilizes self-amplifying property enhance therapeutic efficacy. PCOFs demonstrate exceptional photosensitivity generation capabilities when employed as carriers. When exposed ROS, TA within nanoplatform was activated cleaved into cinnamaldehyde (CA), highly potent compound. By leveraging visible light activate site-specific infection targeting, PCOF effectively alleviated periodontitis, thereby advancing field systems.

Язык: Английский

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Developing functional hydrogels for treatment of oral diseases

Smart Medicine, Год журнала: 2024, Номер 3(3)

Опубликована: Июль 25, 2024

Oral disease is a severe healthcare challenge that diminishes people's quality of life. Functional hydrogels with suitable biodegradability, biocompatibility, and tunable mechanical properties have attracted remarkable interest been developed for treating oral diseases. In this review, we present up-to-date research on the management dental caries, endodontics, periapical periodontitis, depending progression The strategies mucosal diseases salivary gland are then classified. After that, focus application related to tumor therapy tissue defects. Finally, review prospects restrictions perspectives utilization in treatment. We believe will promote advancement more amicable, functional personalized approaches

Язык: Английский

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Dietary Natural Melanin Nanozymes Delay Aging and Ameliorate Neurodegeneration via Improving Gut Microbiota and Redox Homeostasis

ACS Omega, Год журнала: 2025, Номер 10(4), С. 3610 - 3621

Опубликована: Янв. 22, 2025

Aging is an inevitable multifactor process that causes a decline in organ function and increases the risk of age-related diseases death. Thus, development highly effective safe therapeutic strategies to delay aging urgently required. In this study, we isolated natural melanin nanozymes (NMNs) from ink sacs live octopuses. The NMNs exhibited excellent superoxide-dismutase-mimicking radical scavenging activities. SAMP8 mice, treatment with improved their cognition memory functions while restoring aging-impaired liver lipid metabolism, thereby prolonging lifespan. Moreover, reversed metabolic changes aged brains reconstructed gut microbiota composition by enhancing microbial community diversity. Our findings indicate could be promising approach for delaying preventing age-associated physiological humans.

Язык: Английский

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3D printing of GelMA/nanohydroxyapatite/melanin nanoparticles composite hydrogel scaffolds for bone regeneration through immunomodulation

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141453 - 141453

Опубликована: Фев. 1, 2025

Язык: Английский

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Plant and animal-derived fusion nanovesicles rescue inflammation-compromised osteogenic potential of periodontal ligament stem cells

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 27, 2025

Periodontitis is a chronic inflammatory disease affecting the supporting tissues of teeth and has emerged as global public health issue. Current therapies primarily address pathogenic factors alleviate symptoms, with limited options available for complete restoration reconstruction already absorbed periodontal bone tissue. In this study, we developed nanotherapeutic strategy utilizing fusion nanovesicles (FVs) to modulate microenvironment create regenerative niche ligament stem cells (PDLSCs), which play crucial role in tissue repair. The FVs are composed Scutellaria baicalensis (SBNVs) anti-Porphyromonas gingivalis (P. gingivalis) anti-inflammatory properties, combined PDLSC membrane-derived genetically engineered express TNFR1. These preserved biological activity SBNVs immunomodulatory function PDLSCs. Additionally, effectively captured cleared TNF-α from through Moreover, alleviated response PDLSCs induced by P. gingivalis-LPS (Pg-LPS) TNF-α, restoring their proliferation, migration, osteogenic differentiation capabilities. Hence, holds great potential treating periodontitis.

Язык: Английский

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Dual-functional Zn@melanin nanoparticles for enhanced antibacterial activity and prolonged fruit preservation

Food Chemistry, Год журнала: 2025, Номер 479, С. 143844 - 143844

Опубликована: Март 10, 2025

Язык: Английский

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Pd Icosahedral Nanoparticles Promote Skin Wound Healing by Enhancing SP1-HBEGF Axis-Mediated Keratinocytes Proliferation

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 3067 - 3081

Опубликована: Март 1, 2025

Introduction: Impaired wound healing leads to compromised cutaneous barrier and dysfunction, which still remains a challenging problem. However, safe efficient materials treatments for promoting are lacking. Metal nanoparticles especially palladium (Pd NPs) have attracted tremendous interests in medical application recent years, due its unique physicochemical properties biological inertness. Thereinto, Pd icosahedra Icos octahedra Oct superior catalytic activity compared other shapes but the skin not been studied reported. Methods: NPs were synthesized by seed-mediated growth method one-step synthesis characterized series physical chemical assays. The acute full-thickness excision mouse model was used access potential screen out effective materials—Pd NPs. Next evaluate biotoxicity safety of both HaCaT cells vivo. Further examine related molecules expression RT-qPCR WB tissues with treatment. Then knockout vivo validate molecular mechanism these phenotype promoted Results: surface tensile strain rather than can promote healing. upregulates HBEGF production transcription factor SP1, contributes keratinocytes proliferation accelerating Discussion: represent an material healing, suggesting novel therapeutic strategy. Keywords: icosahedral nanoparticles, keratinocytes, cell proliferation, HBEGF, SP1

Язык: Английский

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Applications of Matrix Metalloproteinase-9-Related Nanomedicines in Tumors and Vascular Diseases

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 479 - 479

Опубликована: Апрель 7, 2025

Matrix metalloproteinase-9 (MMP-9) is implicated in tumor progression and vascular diseases, contributing to angiogenesis, metastasis, extracellular matrix degradation. This review comprehensively examines the relationship between MMP-9 these pathologies, exploring underlying molecular mechanisms signaling pathways involved. Specifically, we discuss contribution of epithelial–mesenchymal transition, as well its involvement a spectrum including macrovascular, cerebrovascular, ocular diseases. focuses on recent advances MMP-9-targeted nanomedicine strategies, highlighting design application responsive nanoparticles for enhanced drug delivery. These nanotherapeutic strategies leverage overexpression achieve targeted release, improved penetration, reduced systemic toxicity. We explore various nanoparticle platforms, such liposomes polymer nanoparticles, their action, degradation, targeting specificity. Finally, address challenges posed by heterogeneity expression implications personalized therapies. Ultimately, this underscores diagnostic therapeutic potential nanomedicines against tumors

Язык: Английский

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Flexible Photothermal Phase Change Material with High Photothermal Properties Achieved by Promoted Dispersion of Hydrophobically Modified Eumelanin and its Photovoltaic Applications

Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract Photothermal phase change materials (PPCMs) are prevalent in energy harvesting and thermal management, owing to their dual functionality of solar‐to‐heat conversion latent heat storage capacity. However, conventional PPCMs still face challenges, including reliance on non‐renewable photothermal agents, low efficiency, leakage issues, inflexibility, which collectively hinder widespread application. Here, a flexible with high properties is prepared by modifying eumelanin oleoyl chloride improved interfacial compatibility Styrene‐butadiene rubber (SBR), followed uniform incorporation paraffin wax (PW) into the matrix via physical mixing. The composite exhibits considerable elongation at break 412.0%, acceptable tensile strength 1 MPa, outstanding efficiency up 81.7% only 2 wt.% modified eumelanin. Furthermore, material maintains meagre rate 0.81% PW content 70 wt.%, accompanied favorable melting 144.98 J g −1 freezing 145.30 . Thanks these excellent properties, obtained has potential applications management. Moreover, its integration Seebeck thermoelectric generator produces enough output power range small appliances, miniature fans, electronic clocks light bulbs.

Язык: Английский

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