Food Materials Research, Год журнала: 2020, Номер 0(0), С. 1 - 5
Опубликована: Янв. 1, 2020
Язык: Английский
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 21, 2024
Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.
Язык: Английский
Процитировано
44
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual delivery bioefficacy are extremely restricted by their poor solubility, interior gastrointestinal retention, base permeability. Herein, we developed controllable colon-targeting nanoparticles (NPs) composed a quaternary ammonium chitosan (HTCC) shell succinic acid-modified γ-cyclodextrin (SACD) core precise UC treatment. Egg white-derived peptides (EWDP, typical food-derived peptides) could not only function as potential cross-linkers to induce differential coassembly with above biopolymers but also aid hydrophobic curcumin (Cur) solubility well nutrition enhancers oral synergism therapy. More specifically, NPs higher EWDP efficiency exhibited better pH-sensitive colloidal tunability (e.g., smaller size, rigidity, roughness) robust (EWDP/Cur) coloading capacity (24.0–33.2% ≫ 10%, pH 2.0–7.0). Compared pure nutraceuticals, excellent cellular absorption (almost 10 times) bioavailability (4.19–5.05 enhancement via faster mucus permeation macropinocytosis transport, indirectly regulating systemic inflammatory response. The sustainable sequential release targeted accumulation profiles directly facilitated interactions colonic microenvironment, verified intestinal barrier recovery gut microbiota restoration. Moreover, critical role amino acid metabolism reconfirmed importance maintaining homeostasis. Overall, this study would provide facile, quantitative, versatile perspective into programmable design peptide EWDP) coassembled nanoplatforms UC.
Язык: Английский
Процитировано
10
Critical Reviews in Food Science and Nutrition, Год журнала: 2024, Номер unknown, С. 1 - 15
Опубликована: Июль 4, 2024
During the application of Whey proteins (WPs), they often have complex interactions with saccharides (Ss), another important biopolymer in food substrate. The texture and sensory qualities foods containing WPs Ss are largely influenced by WPs-Ss. Moreover, combination is possible to produce many excellent functional properties including emulsifying thermal stability. However, between WPs-Ss susceptible some processing conditions. In addition, different interaction ways, can be applied fields. Therefore, non-covalent mechanisms firstly summarized detail, electrostatic interaction, hydrogen bond, hydrophobic van der Waals force. Furthermore, existence modes introduced, coacervates, soluble complexes, segregation, co-solubility. covalent applications formed Maillard reaction (dry or wet heat reaction) occasionally through enzyme induction. Then, two common influencing factors, pH temperature, on non-covalent/covalent bonds introduced. Finally, complexes conjugations improving WP stability, delivery system, emulsification described. This review improve our understanding further promote their wider application.
Язык: Английский
Процитировано
13
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июль 27, 2024
This study focused on developing an optimal formulation of liposomes loaded with bee venom (BV) and coated PEG (BV-Lipo-PEG). The were characterized using dynamic light scattering, transmission electron microscopy, Fourier transform infrared spectroscopy. Among the liposomal formulations, F3 exhibited narrowest size distribution a low PDI value 193.72 ± 7.35, indicating minimal agglomeration-related issues more uniform distribution. BV-Lipo-PEG demonstrated remarkable stability over 3 months when stored at 4 °C. Furthermore, release drug from formulations was found to be pH-dependent. Moreover, favorable entrapment efficiencies, values reaching 96.74 1.49. anticancer potential nanocarriers evaluated through MTT assay, flow cytometry, cell cycle analysis, real-time experiments. functionalization system enhanced endocytosis. IC50 showed notable decrease compared both free BV-Lipo alone, signifying that is effective in inducing death A549 lines. higher apoptotic rate lines other samples. In treated BV-Lipo-PEG, expression levels MMP-2, MMP-9, Cyclin E genes decreased, whereas Caspase3 Caspase9 increased. These findings suggest delivering BV via PEGylated holds significant promise for treatment lung cancer.
Язык: Английский
Процитировано
9
Science China Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
7
Journal of Agriculture and Food Research, Год журнала: 2025, Номер 19, С. 101712 - 101712
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
1
Food Chemistry X, Год журнала: 2024, Номер 25, С. 102149 - 102149
Опубликована: Дек. 30, 2024
Various lipid and biopolymer-based nanocarriers have been developed to encapsulate food ingredients. The selection of nanocarrier type, preparation techniques, loading methods should consider the compatibility nutrient properties, composition, product requirements. This review focuses on for hydrophilic hydrophobic substances, along with a detailed exploration categorization, methods. Both lipid-based nanoparticles exhibit capability or substances. Liposomes nanoemulsions allow simultaneous encapsulation ingredients, while solid nanostructured carriers are suited three-dimensional network structure nanogels can efficiently load functional groups in polysaccharides improve capacity substances through intermolecular interactions. As protein nanoparticles, proteins solubility characteristics analogous bioactives is crucial achieve high efficiency.
Язык: Английский
Процитировано
6
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 265, С. 130897 - 130897
Опубликована: Март 14, 2024
Язык: Английский
Процитировано
5
Foods, Год журнала: 2024, Номер 13(16), С. 2596 - 2596
Опубликована: Авг. 19, 2024
Bioactive compounds (BACs) have attracted much attention due to their potential health benefits. However, such substances problems as difficulty dissolving in water, poor stability, and low intestinal absorption, leading serious limitations practical applications. Nowadays, food colloidal delivery carriers become a highly promising solution safety, controllability, efficiency. The use of natural macromolecules construct can not only regulate the solubility, absorption BACs but also effectively enhance nutritional added value functional foods, improve sensory properties, extend shelf life. Moreover, smart-responsive control release characteristics BACs, thus improving rate human body. This review describes several typical colloid carriers, focuses on physical properties from static structure dynamic release, summarizes applications systems, provides an outlook future development carriers. different compositions structures colloids tend affect stability behaviors, surface rheological predestine application scenarios. vivo effect media should be emphasized exploration safer more controllable carrier systems.
Язык: Английский
Процитировано
5
Food Bioscience, Год журнала: 2024, Номер 61, С. 104978 - 104978
Опубликована: Авг. 23, 2024
Язык: Английский
Процитировано
4