Nano Today, Год журнала: 2024, Номер 60, С. 102559 - 102559
Опубликована: Ноя. 22, 2024
Язык: Английский
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 21, 2024
Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.
Язык: Английский
Процитировано
34
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 300, С. 140186 - 140186
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
2
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160171 - 160171
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Treatment of osteoarthritis (OA) remains challenging owing to its complex pathological microenvironment, which involves reactive oxygen species, chronic inflammation, mitochondrial dysfunction, energy deficiency, and cartilage degeneration. Herein, we report for extracellular vesicles (SP-EVs) derived from the photosynthetic microorganism Spirulina platensis contain antioxidative ATP-dependent active metabolic-related compounds OA treatment. SP-EVs were effectively delivered chondrocytes, demonstrating potential modulating cellular communication homeostasis. To facilitate sustained delivery SP-EVs, rhein hydrogel system was used intra-articular injection (Rh Gel@SP-EVs), demonstrated pH responsiveness under mildly acidic conditions synergistic anti-inflammatory effects. Rh Gel@SP-EVs significantly rescued dysfunction by ameliorating inflammation-mediated oxidative stress restoring membrane in chondrocytes. Improved function facilitates replenishment ATP levels, further contributing balance anabolic catabolic processes within matrix, eventually decelerating progression. also modulated Janus kinase-signal transducer activator transcription 3 signaling pathway, implicated suppressing inflammatory responses. This therapeutic strategy utilized a microalgae-based herbal modulate release offering an effective approach treating regulating metabolism mechanisms.
Язык: Английский
Процитировано
1
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Bone fractures, especially large and complex defects, continue to pose significant challenges in the medical field. Current treatments often rely on autografts or allografts for structural support, which can lead problems such as reduced bioactivity, infection risks, potential pathogen transmission. Nature herbal medicine (NHM), including herbs extracts, offers a promising alternative by effectively modulating inflammatory responses, enhancing osteoblast function, inhibiting bone resorption, thereby facilitating fracture repair. However, traditional drug delivery methods NHM encounter interactions, poor tissue distribution, patient compliance. Biomaterials, engineered interact with biological systems, play essential roles repair, mechanical delivery. When used carriers, biomaterials be combined form stable systems that further promote regeneration. Here applications of are reviewed, hydrogels, extracellular vesicles, cement, conjunction regulating homeostasis aiming provide valuable insights guidance future research therapeutic strategies.
Язык: Английский
Процитировано
0
Acta Materia Medica, Год журнала: 2025, Номер 4(2)
Опубликована: Янв. 1, 2025
The concept of food and medicine homology (FMH) is deeply embedded in traditional Chinese carries historical importance. recent rigorous definition FMH pertains to substances that exhibit both pharmacological nutritional functions, have active ingredients are fundamentally non-toxic appropriate for extended consumption. With the progression modern biotechnology, application this treating diseases has markedly expanded, its intrinsic mechanisms been examined detail. use cancer therapy, as either a primary treatment or an adjuvant paved way low-toxicity treatments. This commentary examines theoretical underpinnings, potential advantages, practical applications prevention, treatment, support enhancement. Advantages including low toxicity, long-term edibility, minimal adverse effects, high patient compliance discussed. Moreover, owing multicomponent multitarget characteristics, may provide novel opportunities therapy. Given lethality associated ethical implications, current research should prioritize fundamental studies investigating Concurrently, preliminary preclinical would be establish solid foundation subsequent clinical trials.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 49, С. 378 - 398
Опубликована: Март 15, 2025
Язык: Английский
Процитировано
0
Biomaterials Advances, Год журнала: 2025, Номер unknown, С. 214294 - 214294
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159988 - 159988
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0