ACS Applied Bio Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 11, 2024
Multielemental transition metal compounds represent a class of promising candidates for the biomedical field due to their unique structure and application potential. However, synthesis process remains challenging, which was subject high-temperature treatment multimetallic elements integrated within one system. Herein, first time, we have fabricated nanotripod,
Язык: Английский
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis usually asynchronous due to opposite effect transport them. Herein, systematic glucose deprivation, by inhibiting upstream uptake promoting downstream consumption, is proposed synchronously evoke ferroptosis. As an example, Au nanodots Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles (FeOOH@Fe-Ap@Au NSs) employed regulate SLC7A11/GSH/GPX4 axis performing disulfidptosis- ferroptosis-mediated therapy synchronously. In this scenario, exhibit oxidase-like activity when consuming massive glucose. Meanwhile, Ap can inhibit downregulating 1, depriving fundamentally. The systematical deprivation limits supplement NADPH suppresses axis, thus solving contradiction addition, efficient delivery exogenous iron ions FeOOH@Fe-Ap@Au NSs self-supplied H2O2 through nanodots-catalytic oxidation facilitate Fenton reaction therewith help amplify a result synchronous occurrence ferroptosis, good efficacy in ovarian cancer therapeutic model.
Язык: Английский
Процитировано
0
Journal of Colloid and Interface Science, Год журнала: 2025, Номер 693, С. 137611 - 137611
Опубликована: Апрель 15, 2025
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Abstract The peroxynitrite anion (ONOO − ) is the product of a specific reaction between nitric oxide (NO) and superoxide (O 2 •− ), showing great potential for treating multidrug‐resistant bacterial infections. However, antibacterial materials with highly efficient ONOO controlled release properties are lacking. In this study, hollow copper single atom nanozyme (Cu HSAz) oxidase (OXD)‐mimicking property rationally designed used first time as effective delivery carrier NO donor N, N ′‐di‐sec‐butyl‐ ′‐dinitroso‐1, 4‐phenylenediamine (BNN6), obtaining Cu HSAz@BNN6. Upon near infrared (NIR)‐II laser irradiation, HSAz@BNN6 simultaneously releases substantial amounts O , which subsequently lead to boosting via cascade reaction. Remarkably, displays excellent efficiency by considerably inhibiting activity methicillin‐resistant Staphylococcus aureus ( MRSA activity. Moreover, in ‐associated wound infections promoting healing. An mechanism study reveals that triggers death firstly damaging membrane, followed destructing metabolism cut adenosine triphosphate energy supply boosts intracellular reactive oxygen species generation, depletes glutathione caused DNA breakage.
Язык: Английский
Процитировано
0
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 320, С. 124565 - 124565
Опубликована: Май 31, 2024
Язык: Английский
Процитировано
1
Analytical Chemistry, Год журнала: 2024, Номер 96(32), С. 13308 - 13316
Опубликована: Июль 30, 2024
NAD(P)H: quinone oxidoreductase-1 (NQO1) plays critical roles in antioxidation and abnormally overexpresses tumors. Developing a fast sensitive method of monitoring NQO1 will greatly promote cancer diagnosis clinical practice. This study introduces transformative colorimetric detection strategy for NQO1, harnessing an innovative competitive substrate mechanism between new NADH oxidase (NOX) mimic, cobalt-nitrogen-doped carbon nanozyme (CoNC). ingeniously exploits the differential consumption presence to modulate generation H
Язык: Английский
Процитировано
1
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Дек. 18, 2024
The innate immune system serves as the host's first line of defense against invading pathogens. Stimulator interferon genes (STING) is a key component this system, yet its relationship with glucose metabolism, particularly in antiviral immunity, remains underexplored. Metabolomics analysis was used for detecting metabolic alterations spleens from STING knockout (KO) and wild-type (WT) mice. Co-immunoprecipitation employed determining ubiquitination TKT. Mass spectrometry interaction proteins STING. Enzyme activity kits were activities TKT G6PD. In study, we demonstrate that herpes simplex virus (HSV) infection activates pentose phosphate pathway (PPP) host cells, thereby initiating an response. Using STING-manipulated cells systemic mice, show positively regulates PPP, which, turn, limits HSV infection. Inhibition PPP significantly reduced production factors dampened STING-induced responses. Mechanistically, discovered interacts transketolase (TKT), enzyme non-oxidative branch reduces via E3 ubiquitin ligase UBE3A, stabilizing Silencing or inhibiting oxythiamine diminished factor production. Our findings reveal plays synergistic role generating during viral suggest activation could serve adjunct strategy therapy.
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 29, 2024
Abstract Nicotinamide adenine dinucleotide (NADH) oxidase (NOX) is key in converting NADH to NAD + , crucial for various biochemical pathways. However, natural NOXs are costly and unstable. NOX nanozymes offer a promising alternative with potential applications bio‐sensing, antibacterial treatments, anti‐aging, anticancer therapies. This review provides comprehensive overview of the types, functional mechanisms, biomedical applications, future research perspectives nanozymes. It also addresses primary challenges directions development nanozymes, underscoring critical need continued investigation this area. These include optimizing catalytic efficiency, ensuring biocompatibility, achieving targeted delivery controlled activity within biological systems. Additionally, exploration novel materials hybrid structures holds great enhancing capabilities Future can involve integrating advanced computational modeling experimental techniques better understand underlying mechanisms design more effective nanozyme candidates. Collaborative efforts across disciplines such as nanotechnology, biochemistry, medicine will be essential unlock full applications.
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 11, 2024
Multielemental transition metal compounds represent a class of promising candidates for the biomedical field due to their unique structure and application potential. However, synthesis process remains challenging, which was subject high-temperature treatment multimetallic elements integrated within one system. Herein, first time, we have fabricated nanotripod,
Язык: Английский
Процитировано
0