Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(16), С. 3857 - 3880
Опубликована: Янв. 1, 2024
Nanomedicine-induced pyroptosis for efficient antitumor immunotherapy has been increasingly prominent at the current stage. In this review, we provide a comprehensive summary and deep discussion on very-recent progresses achieved in field.
Язык: Английский
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Язык: Английский
Процитировано
7
Advanced Functional Materials, Год журнала: 2024, Номер 34(44)
Опубликована: Май 25, 2024
Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.
Язык: Английский
Процитировано
9
Nanoscale, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
A novel calcium-based nanoinducer that simultaneously induces pyroptosis and remodels tumor-associated-macrophages effectively overcomes the immunosuppression for enhancing systemic antitumor immunity.
Язык: Английский
Процитировано
5
Acta Biomaterialia, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
5
Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113580 - 113580
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
0
Cellular Signalling, Год журнала: 2025, Номер 131, С. 111776 - 111776
Опубликована: Март 30, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101745 - 101745
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 30, 2025
During the treatment of solid tumors, local therapeutic approaches carry risk incomplete radical cure, which may lead to rapid tumor growth. Incomplete microwave ablation (iMWA) can induce tumors exhibit highly invasive and uncontrollable growth, is related immunosuppressive microenvironment. A multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) with a biomimetic liposome-modified surface tissues after iMWA developed. In response acidic microenvironment, released traditional Chinese medicine preparation Pien Tze Huang (PZH) reduced protein expressions JAK2-STAT3 signaling pathway, thereby slowing down proliferation growth hepatocellular carcinoma (HCC). Furthermore, ions Ca2⁺ Zn2⁺ cascade enhance killing effect oxidative stress, generating substantial amounts reactive oxygen species. This process induces pyroptosis releases significant quantities damage associated molecular patterns, triggering immune activation mechanisms STING pathway that reshape HCC microenvironment resulting from iMWA. strategy markedly differs previous chemoimmunotherapies, not only effectively addressed problem conventional drugs showing heterogeneous distribution in regions, but also verified critical role played by PZH/Zn@CaNA inhibiting iMWA-induced regulating stress remodeling
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, acts double‐edged sword, making it important optimize strategies functional materials appropriately activate effective disease treatment. This paper summarizes discusses structure, pore formation, molecular mechanisms “executor” Gasdermins, well events preceding following these processes. Subsequently, focus is on reviewing that directly regulate Gasdermin formation target those indirectly before after control activity. Finally, advantages, disadvantages, future prospects designing such are provided, aiming facilitate precise design, pharmacological investigation, clinical translation pyroptosis‐related materials.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162048 - 162048
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0