MedMat.,
Journal Year:
2024,
Volume and Issue:
1(2), P. 74 - 94
Published: Dec. 1, 2024
Cuproptosis,
a
newly
discovered
copper-dependent
mode
of
cell
death,
has
received
extensive
attention
in
the
field
cancer
therapy
due
to
its
specific
activation
pathway.
Rapid
accumulation
large
amounts
copper
ions
within
cells
achieve
overload
is
key
activating
cuproptosis.
Advanced
nanotechnology
offers
considerable
promise
for
delivering
cells,
which
copper-based
nanomaterials
have
been
proposed
evoke
cuproptosis-mediated
therapy.
However,
it
still
great
challenge
induce
specifically
tumors
and
efficiently
activate
subsequent
cuproptosis-related
molecular
pathways.
Therefore,
necessary
summarize
strategies
used
effectively
or
amplify
cuproptosis
based
on
currently
developed
nanomaterials,
providing
ideas
design
future.
In
this
review,
that
can
be
are
systematically
classified
selection.
Subsequently,
sensitization
using
provided
therapeutic
efficiency.
Meanwhile,
combination
therapies
maximizing
treatment
efficacy
delineated.
Ultimately,
remaining
challenges
feasible
future
directions
use
tumor
also
discussed.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(44)
Published: May 25, 2024
Abstract
The
vigorous
development
of
cancer
nanomedicine
has
revolutionized
traditional
oncology
medicine,
but
it
is
also
limited
by
the
continuous
mutation
cunning
cells,
leading
to
apoptosis
insensitivity
and
therapeutic
disappointment.
Inflammatory‐regulated
cell
death
(RCD),
especially
pyroptosis‐related
death,
demonstrates
huge
potential
for
sensitization
due
its
unique
biochemical
characteristics.
aim
this
research
present
a
thorough
synopsis
current
knowledge
on
pyroptosis‐associated
inflammatory
including
pyroptosis,
cuproptosis,
PANoptosis,
synergistic
function
in
nano
therapy.
Paradigm
studies
death‐mediated
apoptosis‐sensitizing
tumor
nanotherapeutics
are
introduced
detail,
coordination
mechanisms
based
nanomaterials
discussed.
In
addition,
multi‐angle
analysis
future
prospects
pyroptosis‐sensitized
various
emphasized
further
expand
application
scope
RCD.
It
believed
that
emerging
auxiliary
treatments
RCD
will
greatly
promote
progress
nanomedicine.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
A
novel
calcium-based
nanoinducer
that
simultaneously
induces
pyroptosis
and
remodels
tumor-associated-macrophages
effectively
overcomes
the
immunosuppression
for
enhancing
systemic
antitumor
immunity.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Abstract
Targeted
regulation
of
pyroptosis
to
modulate
the
immune
landscape
has
emerged
as
a
novel
design
strategy
for
cancer
immunotherapy
and
anti‐inflammatory
therapy.
However,
acts
double‐edged
sword,
making
it
important
optimize
strategies
functional
materials
appropriately
activate
effective
disease
treatment.
This
paper
summarizes
discusses
structure,
pore
formation,
molecular
mechanisms
“executor”
Gasdermins,
well
events
preceding
following
these
processes.
Subsequently,
focus
is
on
reviewing
that
directly
regulate
Gasdermin
formation
target
those
indirectly
before
after
control
activity.
Finally,
advantages,
disadvantages,
future
prospects
designing
such
are
provided,
aiming
facilitate
precise
design,
pharmacological
investigation,
clinical
translation
pyroptosis‐related
materials.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
During
the
treatment
of
solid
tumors,
local
therapeutic
approaches
carry
risk
incomplete
radical
cure,
which
may
lead
to
rapid
tumor
growth.
Incomplete
microwave
ablation
(iMWA)
can
induce
tumors
exhibit
highly
invasive
and
uncontrollable
growth,
is
related
immunosuppressive
microenvironment.
A
multifunctional
bimetallic
Ca/Zn
nanoagonist
(PZH/Zn@CaNA)
with
a
biomimetic
liposome-modified
surface
tissues
after
iMWA
developed.
In
response
acidic
microenvironment,
released
traditional
Chinese
medicine
preparation
Pien
Tze
Huang
(PZH)
reduced
protein
expressions
JAK2-STAT3
signaling
pathway,
thereby
slowing
down
proliferation
growth
hepatocellular
carcinoma
(HCC).
Furthermore,
ions
Ca2⁺
Zn2⁺
cascade
enhance
killing
effect
oxidative
stress,
generating
substantial
amounts
reactive
oxygen
species.
This
process
induces
pyroptosis
releases
significant
quantities
damage
associated
molecular
patterns,
triggering
immune
activation
mechanisms
STING
pathway
that
reshape
HCC
microenvironment
resulting
from
iMWA.
strategy
markedly
differs
previous
chemoimmunotherapies,
not
only
effectively
addressed
problem
conventional
drugs
showing
heterogeneous
distribution
in
regions,
but
also
verified
critical
role
played
by
PZH/Zn@CaNA
inhibiting
iMWA-induced
regulating
stress
remodeling
