Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 393 - 410
Опубликована: Дек. 25, 2024
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 19, 2024
Immunotherapy has emerged as a powerful weapon against lung cancer, yet only fraction of patients respond to the treatment. Poly(I:C) (PIC) effectively triggers both innate and adaptive immunity. It can also induce immunogenic cell death (ICD) in tumor cells. However, its efficacy is hindered by instability vivo limited cellular uptake. To address this, PIC encapsulated cRGD-functionalized polymersomes (t-PPIC), which significantly increases stability uptake, thus activating dendritic cells (DCs) inducing apoptosis vitro. In murine LLC model, systemic administration t-PPIC suppresses growth leads survival benefits, with 40% mice becoming tumor-free. Notably, provokes stronger ICD tissue elicits more potent stimulation DCs, recruitment natural killer (NK) cells, activation CD8
Язык: Английский
Процитировано
4
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Multidrug resistance (MDR) facilitates tumor recurrence and metastasis, which has become a main cause of chemotherapy failure in clinical. However, the current therapeutic effects against MDR remain unsatisfactory, mainly hampered by rigid structure drug-resistant cell membranes uncontrolled drug release. In this study, based on sequential release strategy, we engineered core–shell nanoparticle (DOX-M@CaP@ATV@HA) depleting cholesterol for reverse MDR. DOX-M@CaP@ATV@HA could accurately target cells due to active targetability hyaluronic acid (HA) toward CD44 receptors. The calcium phosphate (CaP) shell was cleaved lysosomal acidic environment so that cholesterol-lowering atorvastatin (ATV) rapidly released diminish P-glycoprotein (P-gp) level membrane, thereby boosting uptake. Next, doxorubicin (DOX) gradually from hydrophobic core mPEG-DSPE micelle, inflicting irreversible DNA damage triggering apoptosis. nanosystem proven both vitro vivo effectively exhibited remarkable efficacy tumors with high biosafety. conclusion, reverses via depletion, provides an innovative strategy treatment.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141737 - 141737
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136086 - 136086
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
3
MedComm, Год журнала: 2024, Номер 5(8)
Опубликована: Июль 20, 2024
Abstract Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli‐responsive nanomaterials that can respond endogenous or exogenous stimulus display strong potentials biomedical applications. In comparison with conventional nanomaterials, improve therapeutic efficiency reduce the toxicity of drugs toward normal tissues through specific targeting on‐demand release at pathological sites. this review, we summarize responsive mechanism a variety stimulus, including pH, redox, enzymes within microenvironment, as well such thermal effect, magnetic field, light, ultrasound. After that, applications (e.g., delivery, imaging, theranostics) diverse array common diseases, cardiovascular cancer, neurological disorders, inflammation, bacterial infection, are presented discussed. Finally, remaining challenges outlooks future research directions for also We hope review provide valuable guidance developing accelerate diseases diagnosis treatment.
Язык: Английский
Процитировано
2
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 5605 - 5618
Опубликована: Июнь 1, 2024
Patients diagnosed with glioma typically face a limited life expectancy (around 15 months on average), bleak prognosis, and high likelihood of recurrence. As such, is recognized as significant form malignancy. Presently, the treatment options for include traditional approaches such surgery, chemotherapy, radiotherapy. Regrettably, efficacy these treatments has been less than optimal. Nevertheless, promising development in lies use hydrogel nano-systems sophisticated delivery systems. These have demonstrated exceptional therapeutic effects by various responsive ways, including temperature-response, pH-response, liposome-response, ROS-response, light-response, enzyme-response. This study seeks to provide comprehensive summary both application managing underlying immune action mechanisms.
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 15, 2024
Abstract Temozolomide (TMZ) serves as the principal chemotherapeutic agent for glioma; nonetheless, its therapeutic efficacy is compromised by rapid emergence of drug resistance, inadequate targeting glioma cells, and significant systemic toxicity. ARV‐825 may play a role in modulating resistance degrading BRD4 protein, thereby exerting anti‐glioma effects. Therefore, to surmount TMZ achieve efficient specific delivery, dual‐targeted glutathione (GSH)‐responsive nanoparticle system (T+A@Glu‐NP) designed synthesized co‐delivery TMZ. As anticipated, T+A@Glu‐NPs significantly enhanced penetration blood‐brain barrier (BBB), facilitated uptake exhibited accumulation brain tissue. Additionally, augmented against both vitro vivo through induction apoptosis, inhibition proliferation, cell cycle arrest. Furthermore, mechanistic exploration revealed that degraded leading downregulation Notch1 gene transcription signaling pathway, augmenting chemotherapy. Taken together, findings suggest represents novel promising strategy
Язык: Английский
Процитировано
0
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 393 - 410
Опубликована: Дек. 25, 2024
Язык: Английский
Процитировано
0