Real-time quantification of microfluidic hydrogel crosslinking via gas-phase electrophoresis
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
684, С. 201 - 212
Опубликована: Янв. 7, 2025
Язык: Английский
A bibliometric analysis of hydrogel research in various fields: the trends and evolution of hydrogel application
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 31, 2025
Hydrogel,
a
polymer
material
with
three-dimensional
structure,
has
considerably
expanded
in
research
across
multiple
fields
lately.
However,
the
lack
of
comprehensive
review
integrating
status
hydrogel
diverse
hindered
development
hydrogel.
This
bibliometric
analysis
reviewed
hydrogel-related
over
past
decades,
emphasizing
evolution,
status,
and
future
directions
within
multitude
fields,
such
as
materials
science,
chemistry,
engineering,
physics,
biochemistry
molecular
biology,
pharmacology
pharmacy,
cell
biotechnology
applied
microbiology,
etc.
We
encapsulated
applications
potential
wound
healing,
drug
delivery,
encapsulation,
bioprinting,
tissue
electronic
products,
environment
applications,
disease
treatment.
study
integrated
current
matrix
system
characteristics
hydrogels,
aiming
to
offer
cross-field
reference
for
researchers
promote
advancement
research.
Furthermore,
we
proposed
novel
reproducible
paradigm,
which
can
provide
more
trends
trajectory
field.
Язык: Английский
Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160620 - 160620
Опубликована: Фев. 1, 2025
Язык: Английский
Topological cues of microparticles train stem cells for tissue repair via mechanotransduction
Bioactive Materials,
Год журнала:
2025,
Номер
48, С. 531 - 549
Опубликована: Март 3, 2025
Язык: Английский
NebulaPlate: a droplet microfluidic platform to analyze platelet aggregation
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 5, 2025
The
accurate
assessment
of
platelet
activity
is
crucial
in
clinical
practice
and
scientific
research
owing
to
the
pivotal
role
platelets
progression
cardiovascular
conditions,
such
as
arterial
thrombotic
diseases.
However,
conventional
methods
are
currently
limited
by
their
requirement
substantial
blood
samples
inadequate
high-throughput
capabilities,
therapeutic
resistance
induced
antiplatelet
agents
impedes
treatment
efficacy.
In
this
study,
we
developed
a
microdroplet-based
function
detection
method,
referred
NebulaPlate,
achieve
miniaturized
robust
assessment,
thereby
overcoming
current
challenges.
NebulaPlate
supports
merging
with
drugs
confined
picoliter
microdroplets
leverages
an
imaging-based
analysis
automatically
identify
platelets,
evaluate
aggregation,
determine
P-selectin
expression
within
anchored
microdroplets.
We
experimentally
confirmed
feasibility
aggregation
assays
on
using
various
representative
drugs.
Requiring
only
0.3
mL
whole
blood/chip,
which
corresponds
approximately
100
platelets/reaction,
reduced
consumption
single
assay.
This
represents
reduction
10
times
compared
that
techniques.
Moreover,
our
experimental
results
validity
reproducibility
performed
NebulaPlate.
Our
highlights
important
developments
field
provides
fresh
prospects
for
future
therapies
personalized
medicine.
it
introduces
new
possibilities
related
Язык: Английский
Recent advances of macroporous hydrogel microparticles: Fabrication and applications
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 161435 - 161435
Опубликована: Март 1, 2025
Язык: Английский
A Narrative Review of Bioactive Hydrogel Microspheres: Ingredients, Modifications, Fabrications, Biological Functions, and Applications
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Abstract
Hydrogel
microspheres
are
important
in
regenerative
medicine
and
tissue
engineering,
acting
as
cargos
of
cells,
drugs,
growth
factors,
bio‐inks
for
3D
printing,
medical
devices.
The
antimicrobial
anti‐inflammatory
characteristics
hydrogel
good
treating
injured
tissues.
However,
the
biological
properties
should
be
modified
optimal
treatment
various
body
parts
with
different
physiological
biochemical
environments.
In
addition,
specific
preparation
methods
required
to
produce
customized
shapes
sizes
clinical
applications.
Herein,
advances
biomedical
applications
reviewed.
Synthesis
precursor
solutions,
manufacturing
methods,
strategies
enhancing
functions
these
described.
involvement
bioactive
repair
is
also
discussed.
This
review
anticipates
fostering
more
insights
into
design,
production,
application
biomedicine.
Язык: Английский
Cerium Nanozyme‐Powered Hydrogel Microspheres Alleviate Thromboangiitis Obliterans via Enhanced Stem Cell Therapy
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Abstract
Thromboangiitis
obliterans
(TAO)
is
a
chronic
peripheral
vascular
condition
characterized
by
thrombotic
and
inflammatory
acceleration.
As
promising
therapeutic
modality
for
the
TAO,
mesenchymal
stem
cells
(MSCs)
transplantation
expected
to
circumvent
traditional
drug
therapy
surgical
interventions.
Nonetheless,
MSCs
hindered
owing
poor
survival,
retention,
engraftment
of
transplanted
cells.
The
objective
this
research
develop
MSCs‐
cerium
oxide
nanoparticles
(CeNPs)‐laden
injectable
methacrylated
gelatin
(GelMA)‐based
hydrogel
microspheres
using
microfluidics
discern
their
potential
regulate
oxidative
stress
inflammation
in
rat
model
TAO.
CeNPs‐loaded
photocroslinkable
GelMA
not
only
protected
against
but
also
facilitated
endothelial
functional
recovery,
revascularization
ischemic
limb,
suppression
factors
from
macrophages.
further
conferred
mechanical
support
prolonged
residence
time
enhance
efficacy
cell
therapy.
In
vivo
study
confirmed
that
combination
CeNPs
microsphere
exhibited
positive
synergistic
effect
on
tissue
recovery
angiogenesis.
Taken
together,
work
presents
novel
approach
based
integration
nano‐micron
combined
microspheres,
which
may
have
implications
TAO
Язык: Английский
Janus Hydrogels: Advanced Fabrication Techniques and Versatile Applications in Solar Evaporation, Biomedicine, and Electronic/Strain Sensors
ACS Applied Polymer Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Язык: Английский
High-throughput Generation of Collagen Microbeads for 3D Cell Culture and Extracellular Vesicle Production
Samantha Ali,
Fabiana Mastantuono,
Andrea Orozco-Torres
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 3, 2024
ABSTRACT
Collagen
type
I,
a
fundamental
component
of
natural
extracellular
matrices
across
species,
is
an
attractive
material
for
the
development
tissue
engineering
constructs.
Nevertheless,
poor
mechanical
properties
and
thermal
instability
hinder
its
use
specific
construction
3D
cultures
printing.
In
this
study,
we
present
microfluidic
high-throughput
approach
producing
high-quality
uniform
collagen
microbeads
without
introducing
any
chemical
modification.
We
achieved
rapid
droplet
fabrication
with
sizes
spanning
from
50
µm
to
1200
in
production
rate
up
10000
droplets
per
minute.
The
resulting
can
serve
as
numerous
microbioreactors
which
are
suspended
culture
medium
precipitation
ideal
cell
growth.
demonstrated
excellent
compatibility,
facilitating
attachment
proliferation,
well
promoting
vesicle
secretion
microbeads.
This
technology
facile
versatile
high
throughput
culture,
heterogeneous
modeling,
production,
essential
drug
delivery
screening.
Язык: Английский