Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158946 - 158946
Опубликована: Дек. 1, 2024
Язык: Английский
Burns & Trauma, Год журнала: 2025, Номер 13
Опубликована: Янв. 1, 2025
Abstract Diabetic wounds present a significant challenge in clinical treatment and are characterized by chronic inflammation, oxidative stress, impaired angiogenesis, peripheral neuropathy, heightened risk of infection during the healing process. By creating small channels surface skin, microneedle technology offers minimally invasive efficient approach for drug delivery treatment. This article begins outlining biological foundation normal skin wound unique pathophysiological mechanisms diabetic wounds. It then delves into various types, materials, preparation processes microneedles. The focus is on application multifunctional microneedles treatment, highlighting their antibacterial, anti-inflammatory, immunomodulatory, antioxidant, angiogenic neural repair properties. These demonstrate synergistic therapeutic effects directly influencing microenvironment, ultimately accelerating advancement not only holds promise enhancing outcomes but also new strategies addressing other
Язык: Английский
Процитировано
2
Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1188 - 1188
Опубликована: Сен. 8, 2024
Skin and soft-tissue infections require significant consideration because of their prolonged treatment duration propensity to rapidly progress, resulting in severe complications. The primary challenge stems from the involvement drug-resistant microorganisms that can form impermeable biofilms, as well possibility infection extending deep into tissues, thereby complicating drug delivery. Dissolving microneedle patches are an innovative transdermal drug-delivery system effectively enhances penetration through stratum corneum barrier, increasing concentration at site infection. They offer highly efficient, safe, patient-friendly alternatives conventional topical formulations. This comprehensive review focuses on recent advances emerging trends dissolving-microneedle technology for antimicrobial skin-infection therapy. Conventional antibiotic microneedles compared with those based agents, such quorum-sensing inhibitors, peptides, antimicrobial-matrix materials. also highlights potential incorporating chemodynamic, nanoenzyme antimicrobial, photodynamic, photothermal antibacterial therapies. explores advantages various therapies emphasizes combined application improve efficacy microneedles. Finally, this analyzes druggability different discusses possible future developments.
Язык: Английский
Процитировано
5
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Electrospinning provides exceptional flexibility in fabricating wound dressings. However, constructing 3D fibrous dressings presents a challenge. Herein, multifunctional electrospinning fiber sponge (EFS) is developed by combining the humidity-controlled with freeze-drying solidification for chronic healing. The moisture-induced phase separation triggered spontaneous crimping and stacking of polylactic acid electrospun fibers into unique fluffy structure, endowing EFS excellent water absorption blood-absorbent hemostatic properties. Subsequent further enhances shape stability compression elasticity EFS. Compared to its membrane rival, drug (Curcumin Ciprofloxacin hydrochloride)-loaded (CC@EFS) exhibits superior antibacterial antioxidant capabilities due effective release therapeutic agents facilitated high porosity. In vivo experiments demonstrate that CC@EFS significantly accelerates infected healing killing bacteria, alleviating inflammation, promoting angiogenesis. Overall, this work paves an accessible way engineering innovative improved management.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 3, 2025
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 16, 2025
Probiotics such as Lactobacillus and Bifidobacterium spp. have been shown to be critical for maintaining host homeostasis. In recent years, key compounds of postbiotics derived from probiotic metabolism cellular secretion identified their role in organ immunity regulating intestinal inflammation. particular, probiotic-derived extracellular vesicles (PEVs) can act postbiotics, almost the same functional activity probiotics. They also strong biocompatibility loading capacity carry exogenous or parental active molecules reach distal organs play roles. This provides a new direction understanding intrinsic microbiota-host communication mechanism. However, most current studies on PEVs are limited effects/benefits, specific physicochemical properties, composition, mechanisms homeostasis, possible threats remain explored. Here, we review summarize unique properties bioactivities mediating communication, elucidate limitations research potential application postbiotics.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144882 - 144882
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0
Clinical Cosmetic and Investigational Dermatology, Год журнала: 2024, Номер Volume 17, С. 2417 - 2426
Опубликована: Окт. 1, 2024
Skin photoaging, resulting from prolonged exposure to ultraviolet (UV) radiation, is characterized by intricate biological changes involving oxidative damage and structural alterations. Despite an increasing demand for effective interventions, the current therapeutic options treating skin photoaging are limited. We discovered through literature data search on PubMed that recent research has shifted its focus application of microneedle patches as innovative approach address this concern. Microneedle patches, serving a novel transdermal delivery system, exhibit potential deliver bioactive substances such cytokines, cellular vesicles, gene fragments even alive algae mitigate effects photoaging. This review aims provide comprehensive overview advancements in about utilizing treatment future directions leveraging clinical agents rejuvenation. Ultimately, we believe have broader prospect fields medical cosmetology anti-photoaging.
Язык: Английский
Процитировано
1
Extracellular Vesicle, Год журнала: 2024, Номер 4, С. 100057 - 100057
Опубликована: Ноя. 26, 2024
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158946 - 158946
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1