Biomaterials, Год журнала: 2024, Номер 316, С. 123006 - 123006
Опубликована: Дек. 11, 2024
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 20, 2025
The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes
Язык: Английский
Процитировано
3
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer
Язык: Английский
Процитировано
2
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 11, 2025
Sonodynamic therapy (SDT) is a noninvasive approach to tumor treatment, with ongoing efforts being focused on developing highly effective sonosensitizers low toxicity. Herein, liquid-phase stripping technique was introduced as simple reflux method for synthesizing ultrasmall Mn-PCN-224 nanodots (MM NDs). Compared PCN-224 nanodots, the synthesized MM NDs, which function renal-clearable nanoagents, produced 2.42 times more reactive oxygen species (ROS) under identical ultrasound (US) irradiation conditions. In vivo and in vitro experiments revealed that A549 lung cancer cells treated NDs US H2O2 exhibited relative cell viability of ∼9% inhibition rate ∼91%. This result demonstrates can efficiently increase effectiveness SDT by leveraging their catalase-like activity size (4 nm) prevent ROS quenching. Furthermore, these nanoagents could be effectively utilized photoacoustic (PA) imaging track accumulation tumors monitor alleviation hypoxic microenvironment. Notably, ND-mediated demonstrated superior penetration depth compared PDT, making it inhibiting contralateral while facilitating deep-tissue treatment. Thus, this study introduces promising potential PA-guided SDT, thereby paving way treatment strategies.
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2025, Номер 508, С. 160962 - 160962
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
1
Journal of Nanotheranostics, Год журнала: 2025, Номер 6(2), С. 10 - 10
Опубликована: Апрель 9, 2025
Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160713 - 160713
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Despite its antitumor promise, sonodynamic therapy (SDT)'s efficacy in immune activation requires enhancement, primarily due to the hypoxic tumor microenvironment (TME) and insufficient targeting of sonosensitizers specific subcellular regions. Herein, we developed macrophage membrane (MM)-intermingled fusogenic liposomes (MFL) optimize sonoimmunotherapy that encapsulate catalase (CAT) within core incorporate sonosensitizer chlorin e6 (Ce6) outer shell (CAT@MM-MFL-Ce6). The MM confers evasion properties promotes nanoparticles' targeted accumulation tissue. fusion effect enables Ce6 anchor onto cancer cell facilitates direct delivery CAT into cytoplasm, bypassing endosomal degradation. Upon ultrasound stimulation, generated reactive oxygen species directly damage plasma membrane, initiating Caspase 3/Gasdermin E-mediated pyroptosis pathway. Concurrently, encapsulated efficiently decompose H₂O₂ thus enhancing local levels tumors. Contributed by these effects, combination nanosonosensitizer-augmented SDT checkpoint agent successfully reverse immunosuppressive TME, driving a potent response inhibits primary growth, distant metastasis, lung metastases an orthotopic triple-negative breast model. This study demonstrates potential novel SDT-based combinatorial approach modulate immune-cold TMEs, advancing proof-of-concept therapeutics.
Язык: Английский
Процитировано
0
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 253, С. 114718 - 114718
Опубликована: Апрель 21, 2025
Язык: Английский
Процитировано
0
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Hepatocellular carcinoma (HCC) is the most common primary malignant disease of liver. Although immunotherapy offers new opportunities for treating advanced HCC, its therapeutic effect still limited by immunosuppressive tumor microenvironment (TME). Herein, a nanosensitizer RGD@Ce6@MSA-2@Liposome (RCM-Lip) synthesized to specifically initiate HCC immune through sonodynamic therapy (SDT)-triggered immunogenic cell death (ICD) and MSA-2-activated cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway. RCM-Lip consists sonosensitizer (Chlorin e6, Ce6) with STING agonist (MSA-2) targeting peptide RGD inserted on outer liposome surface. Under ultrasound irradiation, generates reactive oxygen species that induce cytotoxicity apoptosis cells. Meanwhile, antigens released are taken up dendritic cells (DCs), while activated in DCs MSA-2. Moreover, DC maturation stimulated, further enhancing systematic anti-tumor responses. Sono-immunotherapy mediated promotes infiltration CD8+T cells, increasing inflammatory cytokine secretion. Consequently, immunologically "cold" TME successfully turned into "hot" one, leading significant suppression good bio-safety. These results suggest promising method precise synergistic cancer sono-immunotherapy. STATEMENT OF SIGNIFICANCE: Our study addressed dilemma hepatocellular as an immunological application (SDT) agonist. The cGAS-STING signaling pathway plays pivotal role innate immunity against cancer, but clinical agonists were hampered responses due off-target activation. innovative solution introduces RGD-targeted encapsulate agonist, strengthening effects reducing systemic toxicity. targeted sono-immunotherapy promoted producing intense tumor-killing mice model As result, one.
Язык: Английский
Процитировано
0