New horizons for the therapeutic application of nanozymes in cancer treatment

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Language: Английский

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A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Language: Английский

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Renal-Clearable Metalloporphyrin Complex-Based Nanosonosensitizers Using Photoacoustic Imaging Guiding to Enhance Sonodynamic Cancer Therapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Sonodynamic therapy (SDT) is a noninvasive approach to tumor treatment, with ongoing efforts being focused on developing highly effective sonosensitizers low toxicity. Herein, liquid-phase stripping technique was introduced as simple reflux method for synthesizing ultrasmall Mn-PCN-224 nanodots (MM NDs). Compared PCN-224 nanodots, the synthesized MM NDs, which function renal-clearable nanoagents, produced 2.42 times more reactive oxygen species (ROS) under identical ultrasound (US) irradiation conditions. In vivo and in vitro experiments revealed that A549 lung cancer cells treated NDs US H2O2 exhibited relative cell viability of ∼9% inhibition rate ∼91%. This result demonstrates can efficiently increase effectiveness SDT by leveraging their catalase-like activity size (4 nm) prevent ROS quenching. Furthermore, these nanoagents could be effectively utilized photoacoustic (PA) imaging track accumulation tumors monitor alleviation hypoxic microenvironment. Notably, ND-mediated demonstrated superior penetration depth compared PDT, making it inhibiting contralateral while facilitating deep-tissue treatment. Thus, this study introduces promising potential PA-guided SDT, thereby paving way treatment strategies.

Language: Английский

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Recent advances in sonodynamic-derived synergistic strategies against bacterial infections

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 508, P. 160962 - 160962

Published: Feb. 25, 2025

Language: Английский

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Nanotheranostics Revolutionizing Gene Therapy: Emerging Applications in Gene Delivery Enhancement

Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(2), P. 10 - 10

Published: April 9, 2025

Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.

Language: Английский

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Ultrasound-responsive nanoweapons: covalent organic frameworks for cancer sonodynamic therapy

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.

Language: Английский

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Charge separation engineering modulates self-oxygenating nano-heterojunctions to induce ferroptosis for sonodynamic-immunotherapy of tumors

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160713 - 160713

Published: Feb. 1, 2025

Language: Английский

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Membrane‐Anchoring and Oxygen‐Generating Mediated Nanosonosensitizer for Optimizing Cancer Immunotherapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Despite its antitumor promise, sonodynamic therapy (SDT)'s efficacy in immune activation requires enhancement, primarily due to the hypoxic tumor microenvironment (TME) and insufficient targeting of sonosensitizers specific subcellular regions. Herein, we developed macrophage membrane (MM)-intermingled fusogenic liposomes (MFL) optimize sonoimmunotherapy that encapsulate catalase (CAT) within core incorporate sonosensitizer chlorin e6 (Ce6) outer shell (CAT@MM-MFL-Ce6). The MM confers evasion properties promotes nanoparticles' targeted accumulation tissue. fusion effect enables Ce6 anchor onto cancer cell facilitates direct delivery CAT into cytoplasm, bypassing endosomal degradation. Upon ultrasound stimulation, generated reactive oxygen species directly damage plasma membrane, initiating Caspase 3/Gasdermin E-mediated pyroptosis pathway. Concurrently, encapsulated efficiently decompose H₂O₂ thus enhancing local levels tumors. Contributed by these effects, combination nanosonosensitizer-augmented SDT checkpoint agent successfully reverse immunosuppressive TME, driving a potent response inhibits primary growth, distant metastasis, lung metastases an orthotopic triple-negative breast model. This study demonstrates potential novel SDT-based combinatorial approach modulate immune-cold TMEs, advancing proof-of-concept therapeutics.

Language: Английский

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A multifunctional nanoplatform based on chlorin e6 for fluorescence imaging-guided sonodynamic and chemodynamic cancer therapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114718 - 114718

Published: April 21, 2025

Language: Английский

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Targeted Nanosensitizer-Augmented Sono-Immunotherapy with STING Agonist to Remodel the Immune Microenvironment in Hepatocellular Carcinoma

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Hepatocellular carcinoma (HCC) is the most common primary malignant disease of liver. Although immunotherapy offers new opportunities for treating advanced HCC, its therapeutic effect still limited by immunosuppressive tumor microenvironment (TME). Herein, a nanosensitizer RGD@Ce6@MSA-2@Liposome (RCM-Lip) synthesized to specifically initiate HCC immune through sonodynamic therapy (SDT)-triggered immunogenic cell death (ICD) and MSA-2-activated cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway. RCM-Lip consists sonosensitizer (Chlorin e6, Ce6) with STING agonist (MSA-2) targeting peptide RGD inserted on outer liposome surface. Under ultrasound irradiation, generates reactive oxygen species that induce cytotoxicity apoptosis cells. Meanwhile, antigens released are taken up dendritic cells (DCs), while activated in DCs MSA-2. Moreover, DC maturation stimulated, further enhancing systematic anti-tumor responses. Sono-immunotherapy mediated promotes infiltration CD8+T cells, increasing inflammatory cytokine secretion. Consequently, immunologically "cold" TME successfully turned into "hot" one, leading significant suppression good bio-safety. These results suggest promising method precise synergistic cancer sono-immunotherapy. STATEMENT OF SIGNIFICANCE: Our study addressed dilemma hepatocellular as an immunological application (SDT) agonist. The cGAS-STING signaling pathway plays pivotal role innate immunity against cancer, but clinical agonists were hampered responses due off-target activation. innovative solution introduces RGD-targeted encapsulate agonist, strengthening effects reducing systemic toxicity. targeted sono-immunotherapy promoted producing intense tumor-killing mice model As result, one.

Language: Английский

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