Zeitschrift für anorganische und allgemeine Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 31, 2024
Abstract
In
recent
years,
MOFs
hydrogels
have
attracted
extensive
attention
due
to
their
unique
structure
and
excellent
performance.
MOF‐based
combine
the
highly
ordered
pore
tunability
of
MOF
with
biocompatibility
flexibility
hydrogels,
are
widely
used
in
environmental
governance,
sensors,
biomedicine.
this
review,
we
mainly
summarize
synthesis
methods,
structural
characteristics
mechanical
properties
specific
applications
different
fields
including
adsorption
heavy
metal
ions
pollutant
gases
stress
strain
sensor
drug
delivery.
Finally,
analyze
existing
problems,
provide
suggestions
for
development
direction
future.
This
paper
aims
help
readers
quickly
understand
current
hydrogels.
Abstract
Chronic
wounds
are
that
difficult
to
heal
or
do
not
follow
the
normal
healing
process.
These
include
pressure
ulcers,
diabetic
venous
and
arterial
incomplete
ulcers.
Unlike
acute
wounds,
chronic
often
even
heal.
Its
pathogenesis
involves
many
factors;
bacterial
infection
is
main
cause
of
wound.
With
increase
in
population
aging,
incidence
has
become
a
critical
issue
current
medical
health
field.
Management
faced
with
problems
long
treatment
time,
difficulty,
high
cost,
repeated
attacks
disability
rate,
which
seriously
threaten
patients'
ability
take
care
themselves
life
heavy
burden
individuals,
families
society.
Over
past
few
years,
development
antibacterial
hydrogels
for
infections
received
lot
attention.
Since
only
have
mechanical
properties
hydrogels,
biocompatibility
adjustable
functional
structure,
but
also
excellent
properties,
they
may
be
an
ideal
dressing
solve
problem
wound
healing.
This
article
introduces
types
their
characteristics,
challenges
treating
wounds.
It
classifies
antimicrobial
based
on
modes
further
discusses
advancements
smart
along
benefits
obstacles
using
explores
directions
management.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101553 - 101553
Опубликована: Фев. 5, 2025
Wounds
infected
by
bacteria
pose
a
considerable
challenge
in
the
field
of
healthcare,
particularly
with
increasing
prevalence
antibiotic-resistant
pathogens.
Traditional
antibiotics
often
fail
to
achieve
effective
results
due
limited
penetration,
resistance
development,
and
inadequate
local
concentration
at
wound
sites.
These
limitations
necessitate
exploration
alternative
strategies
that
can
overcome
drawbacks
conventional
therapies.
Nanomaterials
have
emerged
as
promising
solution
for
tackling
bacterial
infections
facilitating
healing,
thanks
their
distinct
physicochemical
characteristics
multifunctional
capabilities.
This
review
highlights
latest
developments
nanomaterials
demonstrated
enhanced
antibacterial
efficacy
improved
healing
outcomes.
The
mechanisms
are
varied,
including
ion
release,
chemodynamic
therapy,
photothermal/photodynamic
electrostatic
interactions,
delivery
drugs,
which
not
only
combat
but
also
address
challenges
posed
biofilms
antibiotic
resistance.
Furthermore,
these
create
an
optimal
environment
tissue
regeneration,
promoting
faster
closure.
By
leveraging
unique
attributes
nanomaterials,
there
is
significant
opportunity
revolutionize
management
wounds
markedly
improve
patient
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Abstract
Diabetes‐associated
skin
defects
represent
a
significant
global
health
challenge.
While
flap
grafts
have
been
preferred
treatment
for
soft‐tissue
injuries
in
diabetic
patients,
their
survival
is
often
compromised
by
impaired
vascularization,
infection,
and
the
adverse
pathological
microenvironment.
To
address
these
limitations,
hybrid
photo‐crosslinkable
hydrogel
(HPC)
integrated
hemangioma
stem
cell‐derived
nanovesicle
(HemV)‐loaded
dual‐metal‐polyphenol
network
(dMPN)
(HemV@dMPN/HPC)
developed.
HemVs,
derived
from
highly
vascularized
infantile
tissues,
play
key
role
promoting
cell
proliferation
angiogenesis.
The
dMPN
facilitates
gradual
release
of
copper
(Cu
2+
)
magnesium
ions
(Mg
),
stimulating
angiogenesis
mitigating
inflammation.
HPC
further
sustains
ion
while
preserving
therapeutic
efficacy
HemVs.
Moreover,
both
Cu
act
to
confer
antibacterial
properties,
accelerating
wound
healing.
This
multifunctional
HemV@dMPN/HPC
platform
offers
promising
strategy
treating
large
can
potentially
improve
graft
survival.
Abstract
Wound
healing
is
a
dynamic
process
often
accompanied
by
bacterial
infection.
Bacterial
proliferation
and
induced
excessive
inflammation
hinder
the
in
infectious
wounds,
leading
to
refractory
wounds.
Addressing
challenges
of
wounds
requires
development
multifunctional
dressings
capable
eliminating
infection,
relieving
inflammation,
restoring
wound
microenvironment.
In
this
study,
Ag
+
‐ion
functionalized
Cu
2+
UiO‐67
metal‐organic
framework
(MOF‐Ag
MOF‐Cu)
are
incorporated
into
an
oxidized
dextran
gelatin
mixture
fabricate
hydrogel,
termed
as
OGAC.
The
resulting
OGAC
exhibited
injectable,
adhesive,
hemostatic,
antibacterial,
anti‐inflammatory
properties,
along
with
good
biocompatibility.
hydrogel
precursor
could
be
injected
situ
at
site
cover
wound,
serving
physical
barrier
protect
Moreover,
demonstrates
efficient
antibacterial
anti‐biofilm
activity,
against
both
Escherichia
coli
Staphylococcus
aureus
.
Additionally,
has
superoxide
dismutase‐like
glutathione
peroxidase‐like
activity
for
anti‐oxidation,
which
conducive
reduce
wound.
reveals
high
performance
infected
mouse
model.
These
findings
suggest
that
promising
candidate
multiple
functionalities
clinical
management.
