Biomaterials Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
A nanocoordinator (HTA) combining Aza and TiO 2 induces pyroptosis by restoring GSDME expression generating ROS under ultrasound. This strategy enhances anti-tumor immunity boosts sonodynamic therapy efficacy in breast cancer.
Язык: Английский
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159771 - 159771
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(11), С. 4665 - 4682
Опубликована: Сен. 14, 2024
Aluminum adjuvants (Alum), approved by the US Food and Drug Administration, have been extensively used in vaccines containing recombinant antigens, subunits of pathogens, or toxins for almost a century. While Alums typically elicit strong humoral immune responses, their ability to induce cellular mucosal immunity is limited. As an alternative, layered double hydroxide (LDH), widely antacid, has emerged as novel class potent nano-aluminum (NanoAlum), demonstrating advantageous physicochemical properties, biocompatibility adjuvanticity both responses. In this review, we summarize compare advantages disadvantages Alum NanoAlum these properties performance adjuvants. Moreover, propose key features ideal demonstrate that LDH promising candidate summarizing its current progress immunotherapeutic cancer treatments. Finally, conclude review offering our integrated perspectives about remaining challenges future directions NanoAlum's application preclinical/clinical settings.
Язык: Английский
Процитировано
9
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 7, 2025
Abstract Transarterial chemoembolization (TACE) remains the gold standard for treating intermediate‐stage hepatocellular carcinoma (HCC), yet faces great challenges in overcoming tumor heterogeneity, hypoxia‐induced angiogenesis, and metastatic progression. The development of advanced flexible embolization materials marks a revolutionary leap interventional therapy, offering opportunities to revolutionize precision, drug delivery kinetics, microenvironment modulation. This comprehensive review systematically examines paradigm shift toward next‐generation TACE technology, emphasizing limitations conventional approaches innovations embolic agents. A detailed discussion nano‐flexible systems is presented, their unique coagulation dynamics, real‐time imaging capabilities, therapeutic precision. delves into groundbreaking strategies integrating hypoxia modulation, energy conversion therapeutics, sophisticated engineering. Clinical translation aspects are thoroughly explored, including large‐scale trial outcomes, vascular recanalization patient‐specific treatment optimization. Looking forward, key frontiers field identified: intelligent nanocomposite systems, synergistic combination therapies, precision medicine tailored individual biology. work not only objectively evaluates current progress but also charts future research priorities, aiming transform from palliative intervention platform ultimately reshaping landscape HCC patient care.
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Май 6, 2025
Abstract Sonodynamic therapy (SDT) is a promising cancer treatment due to its ability utilize ultrasound (US) activate sonosensitizers, generating reactive oxygen species (ROS) for tumor suppression. High‐valence bismuth, known unique photoacoustic properties and biocompatibility, has shown great potential when combined with SDT. However, conventional sonosensitizers large bandgaps electron‐hole recombination have limited SDT's effectiveness. Herein, bismuth‐based piezoelectric sonosensitizer developed, DSPE‐PEG 2000‐modified KBiO 3 (KBP), which features reduced bandgap (1.9 eV). This facilitates electron transfer depletes glutathione in the microenvironment. Under US, KBP generates significant amount of ROS, leading cell pyroptosis via ROS‐NLRP3‐Caspase‐1‐GSDMD pathway. Both vitro vivo experiments demonstrated that SDT can effectively inhibit growth. research offers novel approach by leveraging advantages SDT, demonstrating clinical inhibition.
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
A nanocoordinator (HTA) combining Aza and TiO 2 induces pyroptosis by restoring GSDME expression generating ROS under ultrasound. This strategy enhances anti-tumor immunity boosts sonodynamic therapy efficacy in breast cancer.
Язык: Английский
Процитировано
1