2D MOFs nanosheets derived from 2D LDHs as a multifunctional sensitizer for sono-photodynamic therapy-mediated tumor treatment

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159771 - 159771

Published: Jan. 1, 2025

Language: Английский

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Next-generation aluminum adjuvants: Immunomodulatory layered double hydroxides NanoAlum reengineered from first-line drugs

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4665 - 4682

Published: Sept. 14, 2024

Aluminum adjuvants (Alum), approved by the US Food and Drug Administration, have been extensively used in vaccines containing recombinant antigens, subunits of pathogens, or toxins for almost a century. While Alums typically elicit strong humoral immune responses, their ability to induce cellular mucosal immunity is limited. As an alternative, layered double hydroxide (LDH), widely antacid, has emerged as novel class potent nano-aluminum (NanoAlum), demonstrating advantageous physicochemical properties, biocompatibility adjuvanticity both responses. In this review, we summarize compare advantages disadvantages Alum NanoAlum these properties performance adjuvants. Moreover, propose key features ideal demonstrate that LDH promising candidate summarizing its current progress immunotherapeutic cancer treatments. Finally, conclude review offering our integrated perspectives about remaining challenges future directions NanoAlum's application preclinical/clinical settings.

Language: Английский

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Next‐Generation Flexible Embolic Systems: Targeted Transarterial Chemoembolization Strategies for Hepatocellular Carcinoma

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Transarterial chemoembolization (TACE) remains the gold standard for treating intermediate‐stage hepatocellular carcinoma (HCC), yet faces great challenges in overcoming tumor heterogeneity, hypoxia‐induced angiogenesis, and metastatic progression. The development of advanced flexible embolization materials marks a revolutionary leap interventional therapy, offering opportunities to revolutionize precision, drug delivery kinetics, microenvironment modulation. This comprehensive review systematically examines paradigm shift toward next‐generation TACE technology, emphasizing limitations conventional approaches innovations embolic agents. A detailed discussion nano‐flexible systems is presented, their unique coagulation dynamics, real‐time imaging capabilities, therapeutic precision. delves into groundbreaking strategies integrating hypoxia modulation, energy conversion therapeutics, sophisticated engineering. Clinical translation aspects are thoroughly explored, including large‐scale trial outcomes, vascular recanalization patient‐specific treatment optimization. Looking forward, key frontiers field identified: intelligent nanocomposite systems, synergistic combination therapies, precision medicine tailored individual biology. work not only objectively evaluates current progress but also charts future research priorities, aiming transform from palliative intervention platform ultimately reshaping landscape HCC patient care.

Language: Английский

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Cascade‐amplified Oxidative Stress via Bandgap‐Tuned KBiO₃ Perovskite for Cancer Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Sonodynamic therapy (SDT) is a promising cancer treatment due to its ability utilize ultrasound (US) activate sonosensitizers, generating reactive oxygen species (ROS) for tumor suppression. High‐valence bismuth, known unique photoacoustic properties and biocompatibility, has shown great potential when combined with SDT. However, conventional sonosensitizers large bandgaps electron‐hole recombination have limited SDT's effectiveness. Herein, bismuth‐based piezoelectric sonosensitizer developed, DSPE‐PEG 2000‐modified KBiO 3 (KBP), which features reduced bandgap (1.9 eV). This facilitates electron transfer depletes glutathione in the microenvironment. Under US, KBP generates significant amount of ROS, leading cell pyroptosis via ROS‐NLRP3‐Caspase‐1‐GSDMD pathway. Both vitro vivo experiments demonstrated that SDT can effectively inhibit growth. research offers novel approach by leveraging advantages SDT, demonstrating clinical inhibition.

Language: Английский

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A metal–phenolic nanotuner launches cancer pyroptosis for sono-immune therapy

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

A nanocoordinator (HTA) combining Aza and TiO 2 induces pyroptosis by restoring GSDME expression generating ROS under ultrasound. This strategy enhances anti-tumor immunity boosts sonodynamic therapy efficacy in breast cancer.

Language: Английский

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