International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143912 - 143912
Опубликована: Май 1, 2025
Язык: Английский
Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 375 - 375
Опубликована: Март 15, 2025
Recent progress in material science has led to the development of new drug delivery systems that go beyond conventional approaches and offer greater accuracy convenience application therapeutic agents. This review discusses evolutionary role nanocarriers, hydrogels, bioresponsive polymers enhanced release, target accuracy, bioavailability. Oncology, chronic disease management, vaccine are some applications explored this paper show how these materials improve results, counteract multidrug resistance, allow for sustained localized treatments. The also translational barriers bringing advanced into clinical setting, which include issues biocompatibility, scalability, regulatory approval. Methods overcome challenges surface modifications reduce immunogenicity, scalable production methods such as microfluidics, harmonization systems. In addition, convergence artificial intelligence (AI) machine learning (ML) is opening frontiers personalized medicine. These technologies predictive modeling real-time adjustments optimize needs individual patients. use can be applied rare underserved diseases; thus, strategies gene therapy, orphan drugs development, global distribution may hopes millions
Язык: Английский
Процитировано
4
Viruses, Год журнала: 2025, Номер 17(4), С. 556 - 556
Опубликована: Апрель 11, 2025
Vaccination remains the most effective strategy for preventing infectious diseases. Subunit vaccines, which consist of antigenic components derived from pathogens, offer significant advantages in terms biosafety, ease preparation, and scalability. However, subunit vaccines often exhibit lower immunogenicity than whole-pathogen do. To address this limitation, coupling antigens with nanoparticles has emerged as a promising enhancing immune responses by mimicking pathogen structures improving antigen presentation. This study evaluated stability ferritin (F-nps) encapsulin (E-nps) their efficient uptake bone-marrow-derived dendritic cells (BMDCs) vitro. In vivo studies demonstrated targeting lymph nodes. The African swine fever virus C129R protein was conjugated to assess its ability enhance antigen-specific responses. murine models, both F-nps E-nps significantly increased antigen, highlighting potential vaccine delivery systems. These findings underscore promise platforms pave way development nanoparticle-based vaccines.
Язык: Английский
Процитировано
0
Macromolecular Bioscience, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
Abstract Computer‐aided protein design (CAPD) has become a transformative field, harnessing advances in computational power and deep learning to deepen the understanding of structure, function, design. This review provides comprehensive overview CAPD techniques, with focus on their application protein‐based therapeutics such as monoclonal antibodies, drugs, antigens, polymers. starts key methods, particularly those integrating learning‐based predictions generative models. These approaches have significantly enhanced drug properties, including binding affinity, specificity, reduction immunogenicity. also covers CAPD's role optimizing vaccine antigen design, improving stability, customizing polymers for delivery applications. Despite considerable progress, faces challenges model overfitting, limited data rare families, need efficient experimental validation. Nevertheless, ongoing advancements coupled interdisciplinary collaborations, are poised overcome these obstacles, advancing engineering therapeutic development. In conclusion, this highlights future potential transform development, personalized medicine, biotechnology.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143912 - 143912
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0