Revolutionizing Drug Delivery: The Impact of Advanced Materials Science and Technology on Precision Medicine

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 375 - 375

Published: March 15, 2025

Recent progress in material science has led to the development of new drug delivery systems that go beyond conventional approaches and offer greater accuracy convenience application therapeutic agents. This review discusses evolutionary role nanocarriers, hydrogels, bioresponsive polymers enhanced release, target accuracy, bioavailability. Oncology, chronic disease management, vaccine are some applications explored this paper show how these materials improve results, counteract multidrug resistance, allow for sustained localized treatments. The also translational barriers bringing advanced into clinical setting, which include issues biocompatibility, scalability, regulatory approval. Methods overcome challenges surface modifications reduce immunogenicity, scalable production methods such as microfluidics, harmonization systems. In addition, convergence artificial intelligence (AI) machine learning (ML) is opening frontiers personalized medicine. These technologies predictive modeling real-time adjustments optimize needs individual patients. use can be applied rare underserved diseases; thus, strategies gene therapy, orphan drugs development, global distribution may hopes millions

Language: Английский

Ferritin and Encapsulin Nanoparticles as Effective Vaccine Delivery Systems: Boosting the Immunogenicity of the African Swine Fever Virus C129R Protein

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 556 - 556

Published: April 11, 2025

Vaccination remains the most effective strategy for preventing infectious diseases. Subunit vaccines, which consist of antigenic components derived from pathogens, offer significant advantages in terms biosafety, ease preparation, and scalability. However, subunit vaccines often exhibit lower immunogenicity than whole-pathogen do. To address this limitation, coupling antigens with nanoparticles has emerged as a promising enhancing immune responses by mimicking pathogen structures improving antigen presentation. This study evaluated stability ferritin (F-nps) encapsulin (E-nps) their efficient uptake bone-marrow-derived dendritic cells (BMDCs) vitro. In vivo studies demonstrated targeting lymph nodes. The African swine fever virus C129R protein was conjugated to assess its ability enhance antigen-specific responses. murine models, both F-nps E-nps significantly increased antigen, highlighting potential vaccine delivery systems. These findings underscore promise platforms pave way development nanoparticle-based vaccines.

Language: Английский

Encapsulin nanoparticle-conjugated p54 protein boosts immune responses against African swine fever virus

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143912 - 143912

Published: May 1, 2025

Language: Английский