
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 315, С. 144636 - 144636
Опубликована: Май 24, 2025
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 315, С. 144636 - 144636
Опубликована: Май 24, 2025
Язык: Английский
Biomaterials, Год журнала: 2025, Номер unknown, С. 123123 - 123123
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер 7, С. 100516 - 100516
Опубликована: Май 22, 2024
A novel modified chitosan was synthesized using palmitic acid to selectively remove Cd(II), As(III), and Pb(II) from water samples. Chitosan dissolved in acetic solution N, N'-dicyclohexylcarbodiimide used crosslinking agent, further functionalize with introduce O-donor sites the chain. These entrap metal ions forming covalent bonds leading removal of heavy ions. The product characterized Fourier transform-infrared spectroscopy (FTIR), scanning electron microscopy (SEM), elemental analysis, X-ray diffraction (XRD), energy-dispersive spectroscopy, proton nuclear magnetic resonance. introduction into chain did not only alter its original structure crystallinity, as evidenced by XRD SEM data, but enhanced stability increased affinity toward adsorption processes were extensively examined under optimized conditions, results revealed maximum absorptivity values 40.98, 21.8, 47.6 mg/g for Pb(II), respectively, indicating high capacity. kinetic study suggested a pseudo-second-order reaction, Langmuir isotherm model demonstrated best fit. limits detection Cd, As, Pb 2.9, 4.3, 15.1 ppb, while quantification 9.07, 13.23, 45.77 respectively. desorption studies showed regeneration reusability adsorbent up four cycles.
Язык: Английский
Процитировано
6Journal of Controlled Release, Год журнала: 2023, Номер 366, С. 114 - 127
Опубликована: Дек. 30, 2023
Язык: Английский
Процитировано
12Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Окт. 10, 2024
Abstract Nerve guidance conduits have demonstrated great promise for the restoration of injured peripheral nerves in recent decades. Associated research has focused on improving structure and function these as well simplifying manufacturing processes. Herein, a novel decellularized umbilical cord (DUC) wrapped with conductive hydrogel is presented nerve regeneration, which prepared by integrating DUC matrix into methacrylate gelatin (GelMA)/Ti 3 C 2 T x MXene (MXene) composite hollow conduit (named DUC–MXene–GelMA conduit). The obtained displays superior mechanical properties, electrical conductivity, biocompatibility. Particularly, ascribed to introduction MXene, exhibits satisfactory biological effects promoting neuron growth Schwann cell proliferation migration. Through vivo experiments using rat sciatic injury model, beneficial axonal regeneration motor recovery are demonstrated. These findings indicate that may be promising candidate repair.
Язык: Английский
Процитировано
3Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 58 - 58
Опубликована: Янв. 7, 2025
Chronic wounds present a substantial healthcare obstacle, marked by an extended healing period that can persist for weeks, months, or even years. Typically, they do not progress through the usual phases of healing, which include hemostasis, inflammation, proliferation, and remodeling, within expected timeframe. Therefore, to address socioeconomic burden in taking care chronic wounds, hydrogel-based therapeutic materials have been proposed. Hydrogels are hydrophilic polymer networks with 3D structure allows them become skin substitutes wounds. Knowing peptides abundant human body possess distinct biological functionality, activity, selectivity, their adaptability as peptide-based hydrogels individual requirements has made significant potential biomaterial treatment Peptide-based excellent physicochemical mechanical characteristics such biodegradability swelling, suitable rheological properties well great biocompatibility. Moreover, interact cells, promoting adhesion, migration, proliferation. These cellular interactions driven be applied wound healing.
Язык: Английский
Процитировано
0Materials Today Bio, Год журнала: 2025, Номер 31, С. 101511 - 101511
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
0Theranostics, Год журнала: 2025, Номер 15(9), С. 4054 - 4073
Опубликована: Март 10, 2025
Rationale: Osteoarthritis (OA) is a degenerative disease affecting cartilage, synovium and bone, that major cause of pain disability. Intra-articular injection hyaluronic acid (HA) derivatives, also known as viscosupplementation (VS), common treatment for the symptomatic management knee OA. Despite its widespread use, magnitude clinical benefit VS remains controversial, with conflicting results due to methodological differences possible in efficacy between products related remanence rheological properties. Methods: Here, create an effective HA-based treatment, injectable self-healing HA hydrogel long-persistent radiopacity formed by tethering iodine contrast agent HA. The labeling conditions are tuned obtain sufficient X-ray signal without altering biocompatibility, injectability properties hydrogel. Results: enabled monitor not only delivery but retention mouse knees up 5 weeks post-administration using synchrotron K-edge subtraction-computed tomography. We further demonstrated unique this enable creation transient network vivo attenuates OA progression model Moreover, our data showed rate HA-I disappearance appears predict response, likely because rapid elimination serves indirect indicator situ inflammation. Conclusion: Collectively, these show radiopaque holds significant promise improving patient before symptoms worsen. Its capacity tracking over time allows personalized schedules based on observed therapeutic effect. As result, theranostic emerges strong candidate precision medicine
Язык: Английский
Процитировано
0ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 1626 - 1645
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% 33%). Rheological analysis confirmed enhanced viscoelasticity increasing (99Gel-33 > 99Gel-16 23Gel-33 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) carvacrol (CRV), exhibiting tumor-responsive degradation tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% PBS), while CRV showed an initial burst followed sustained promoted mesenchymal stem cell proliferation effectively inhibited triple-negative breast cells. injectable, offers promising platform minimally invasive, personalized therapy.
Язык: Английский
Процитировано
0Talanta, Год журнала: 2025, Номер 293, С. 128110 - 128110
Опубликована: Апрель 10, 2025
Язык: Английский
Процитировано
0