Role of natural plant extracts and hyaluronic acid derivatives in intranasal strategies for brain delivery. A review DOI Creative Commons
Khadija Boualam, Stefania Scialla, Ines Fasolino

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 315, С. 144636 - 144636

Опубликована: Май 24, 2025

Язык: Английский

Probiotic domestication and engineering enable one-shot treatment for bladder mucosal repair DOI
Menglu Li,

Shengkai Jin,

Yichen Lu

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123123 - 123123

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

Synthesis and application of fatty acid-modified chitosan for heavy metal remediation from waste water DOI Creative Commons
Shabbah Begum, Nor Yuliana Yuhana, Noorashikin Md Saleh

и другие.

Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер 7, С. 100516 - 100516

Опубликована: Май 22, 2024

A novel modified chitosan was synthesized using palmitic acid to selectively remove Cd(II), As(III), and Pb(II) from water samples. Chitosan dissolved in acetic solution N, N'-dicyclohexylcarbodiimide used crosslinking agent, further functionalize with introduce O-donor sites the chain. These entrap metal ions forming covalent bonds leading removal of heavy ions. The product characterized Fourier transform-infrared spectroscopy (FTIR), scanning electron microscopy (SEM), elemental analysis, X-ray diffraction (XRD), energy-dispersive spectroscopy, proton nuclear magnetic resonance. introduction into chain did not only alter its original structure crystallinity, as evidenced by XRD SEM data, but enhanced stability increased affinity toward adsorption processes were extensively examined under optimized conditions, results revealed maximum absorptivity values 40.98, 21.8, 47.6 mg/g for Pb(II), respectively, indicating high capacity. kinetic study suggested a pseudo-second-order reaction, Langmuir isotherm model demonstrated best fit. limits detection Cd, As, Pb 2.9, 4.3, 15.1 ppb, while quantification 9.07, 13.23, 45.77 respectively. desorption studies showed regeneration reusability adsorbent up four cycles.

Язык: Английский

Процитировано

6

Self-assembled hyaluronic acid nanoparticles for the topical treatment of inflammatory skin diseases: Beyond drug carriers DOI
Wang‐Hee Lee, Wook Kim

Journal of Controlled Release, Год журнала: 2023, Номер 366, С. 114 - 127

Опубликована: Дек. 30, 2023

Язык: Английский

Процитировано

12

Decellularized umbilical cord wrapped with conductive hydrogel for peripheral nerve regeneration DOI Creative Commons
Bin Zhang, Hui Zhang, Yangnan Hu

и другие.

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Окт. 10, 2024

Abstract Nerve guidance conduits have demonstrated great promise for the restoration of injured peripheral nerves in recent decades. Associated research has focused on improving structure and function these as well simplifying manufacturing processes. Herein, a novel decellularized umbilical cord (DUC) wrapped with conductive hydrogel is presented nerve regeneration, which prepared by integrating DUC matrix into methacrylate gelatin (GelMA)/Ti 3 C 2 T x MXene (MXene) composite hollow conduit (named DUC–MXene–GelMA conduit). The obtained displays superior mechanical properties, electrical conductivity, biocompatibility. Particularly, ascribed to introduction MXene, exhibits satisfactory biological effects promoting neuron growth Schwann cell proliferation migration. Through vivo experiments using rat sciatic injury model, beneficial axonal regeneration motor recovery are demonstrated. These findings indicate that may be promising candidate repair.

Язык: Английский

Процитировано

3

Current Insight of Peptide-Based Hydrogels for Chronic Wound Healing Applications: A Concise Review DOI Creative Commons

Aifa Asyhira Khairul Nizam,

Syafira Masri, Nur Izzah Md Fadilah

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 58 - 58

Опубликована: Янв. 7, 2025

Chronic wounds present a substantial healthcare obstacle, marked by an extended healing period that can persist for weeks, months, or even years. Typically, they do not progress through the usual phases of healing, which include hemostasis, inflammation, proliferation, and remodeling, within expected timeframe. Therefore, to address socioeconomic burden in taking care chronic wounds, hydrogel-based therapeutic materials have been proposed. Hydrogels are hydrophilic polymer networks with 3D structure allows them become skin substitutes wounds. Knowing peptides abundant human body possess distinct biological functionality, activity, selectivity, their adaptability as peptide-based hydrogels individual requirements has made significant potential biomaterial treatment Peptide-based excellent physicochemical mechanical characteristics such biodegradability swelling, suitable rheological properties well great biocompatibility. Moreover, interact cells, promoting adhesion, migration, proliferation. These cellular interactions driven be applied wound healing.

Язык: Английский

Процитировано

0

Injectable hydrogel regulates immune infiltration through physical and chemical synergy in the treatment of steroid-induced osteonecrosis of the femoral head DOI Creative Commons
Zherui Fu,

Yiwen Xu,

Fangqi Xu

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101511 - 101511

Опубликована: Янв. 21, 2025

Язык: Английский

Процитировано

0

A self-healing radiopaque hyaluronic acid hydrogel as a new injectable biomaterial for precision medicine in osteoarthritis DOI Creative Commons
Moustoifa Said, Clément Tavakoli, Chloé Dumot

и другие.

Theranostics, Год журнала: 2025, Номер 15(9), С. 4054 - 4073

Опубликована: Март 10, 2025

Rationale: Osteoarthritis (OA) is a degenerative disease affecting cartilage, synovium and bone, that major cause of pain disability. Intra-articular injection hyaluronic acid (HA) derivatives, also known as viscosupplementation (VS), common treatment for the symptomatic management knee OA. Despite its widespread use, magnitude clinical benefit VS remains controversial, with conflicting results due to methodological differences possible in efficacy between products related remanence rheological properties. Methods: Here, create an effective HA-based treatment, injectable self-healing HA hydrogel long-persistent radiopacity formed by tethering iodine contrast agent HA. The labeling conditions are tuned obtain sufficient X-ray signal without altering biocompatibility, injectability properties hydrogel. Results: enabled monitor not only delivery but retention mouse knees up 5 weeks post-administration using synchrotron K-edge subtraction-computed tomography. We further demonstrated unique this enable creation transient network vivo attenuates OA progression model Moreover, our data showed rate HA-I disappearance appears predict response, likely because rapid elimination serves indirect indicator situ inflammation. Conclusion: Collectively, these show radiopaque holds significant promise improving patient before symptoms worsen. Its capacity tracking over time allows personalized schedules based on observed therapeutic effect. As result, theranostic emerges strong candidate precision medicine

Язык: Английский

Процитировано

0

Artificial Human Blood Vessels for Tissue Engineering DOI
Yi Zhang,

Lina Lin,

Mengying Niu

и другие.

ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 1626 - 1645

Опубликована: Март 27, 2025

Язык: Английский

Процитировано

0

Localized Cancer Treatment Using Thiol–Ene Hydrogels for Dual Drug Delivery DOI Creative Commons

Lakshmi Sathi Devi,

Maria Rosa Gigliobianco, Serena Gabrielli

и другие.

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% 33%). Rheological analysis confirmed enhanced viscoelasticity increasing (99Gel-33 > 99Gel-16 23Gel-33 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) carvacrol (CRV), exhibiting tumor-responsive degradation tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% PBS), while CRV showed an initial burst followed sustained promoted mesenchymal stem cell proliferation effectively inhibited triple-negative breast cells. injectable, offers promising platform minimally invasive, personalized therapy.

Язык: Английский

Процитировано

0

Loading of hyaluronic acid–conjugated MoS2 nanosheets with rhodamine B for sensing hyaluronidase activity in human urine and live cells DOI

Aravindan Varatharajan,

Chia-Chi Chang, Wei‐Lung Tseng

и другие.

Talanta, Год журнала: 2025, Номер 293, С. 128110 - 128110

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

0