Decellularized umbilical cord wrapped with conductive hydrogel for peripheral nerve regeneration DOI Creative Commons
Bin Zhang, Hui Zhang, Yangnan Hu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract Nerve guidance conduits have demonstrated great promise for the restoration of injured peripheral nerves in recent decades. Associated research has focused on improving structure and function these as well simplifying manufacturing processes. Herein, a novel decellularized umbilical cord (DUC) wrapped with conductive hydrogel is presented nerve regeneration, which prepared by integrating DUC matrix into methacrylate gelatin (GelMA)/Ti 3 C 2 T x MXene (MXene) composite hollow conduit (named DUC–MXene–GelMA conduit). The obtained displays superior mechanical properties, electrical conductivity, biocompatibility. Particularly, ascribed to introduction MXene, exhibits satisfactory biological effects promoting neuron growth Schwann cell proliferation migration. Through vivo experiments using rat sciatic injury model, beneficial axonal regeneration motor recovery are demonstrated. These findings indicate that may be promising candidate repair.

Language: Английский

Synthesis and application of fatty acid-modified chitosan for heavy metal remediation from waste water DOI Creative Commons
Shabbah Begum, Nor Yuliana Yuhana, Noorashikin Md Saleh

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 7, P. 100516 - 100516

Published: May 22, 2024

A novel modified chitosan was synthesized using palmitic acid to selectively remove Cd(II), As(III), and Pb(II) from water samples. Chitosan dissolved in acetic solution N, N'-dicyclohexylcarbodiimide used crosslinking agent, further functionalize with introduce O-donor sites the chain. These entrap metal ions forming covalent bonds leading removal of heavy ions. The product characterized Fourier transform-infrared spectroscopy (FTIR), scanning electron microscopy (SEM), elemental analysis, X-ray diffraction (XRD), energy-dispersive spectroscopy, proton nuclear magnetic resonance. introduction into chain did not only alter its original structure crystallinity, as evidenced by XRD SEM data, but enhanced stability increased affinity toward adsorption processes were extensively examined under optimized conditions, results revealed maximum absorptivity values 40.98, 21.8, 47.6 mg/g for Pb(II), respectively, indicating high capacity. kinetic study suggested a pseudo-second-order reaction, Langmuir isotherm model demonstrated best fit. limits detection Cd, As, Pb 2.9, 4.3, 15.1 ppb, while quantification 9.07, 13.23, 45.77 respectively. desorption studies showed regeneration reusability adsorbent up four cycles.

Language: Английский

Citations

6
Recent research progress of hydrogel on cartilage DOI

Qinbin Ma,

Danqi Lin,

Yan Liu

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 213, P. 113115 - 113115

Published: May 17, 2024

Language: Английский

Citations

5
Injectable hydrogel regulates immune infiltration through physical and chemical synergy in the treatment of steroid-induced osteonecrosis of the femoral head DOI Creative Commons
Zherui Fu,

Yiwen Xu,

Fangqi Xu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101511 - 101511

Published: Jan. 21, 2025

Language: Английский

Citations

0
A self-healing radiopaque hyaluronic acid hydrogel as a new injectable biomaterial for precision medicine in osteoarthritis DOI Creative Commons
Moustoifa Said, Clément Tavakoli, Chloé Dumot

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(9), P. 4054 - 4073

Published: March 10, 2025

Rationale: Osteoarthritis (OA) is a degenerative disease affecting cartilage, synovium and bone, that major cause of pain disability. Intra-articular injection hyaluronic acid (HA) derivatives, also known as viscosupplementation (VS), common treatment for the symptomatic management knee OA. Despite its widespread use, magnitude clinical benefit VS remains controversial, with conflicting results due to methodological differences possible in efficacy between products related remanence rheological properties. Methods: Here, create an effective HA-based treatment, injectable self-healing HA hydrogel long-persistent radiopacity formed by tethering iodine contrast agent HA. The labeling conditions are tuned obtain sufficient X-ray signal without altering biocompatibility, injectability properties hydrogel. Results: enabled monitor not only delivery but retention mouse knees up 5 weeks post-administration using synchrotron K-edge subtraction-computed tomography. We further demonstrated unique this enable creation transient network vivo attenuates OA progression model Moreover, our data showed rate HA-I disappearance appears predict response, likely because rapid elimination serves indirect indicator situ inflammation. Conclusion: Collectively, these show radiopaque holds significant promise improving patient before symptoms worsen. Its capacity tracking over time allows personalized schedules based on observed therapeutic effect. As result, theranostic emerges strong candidate precision medicine

Language: Английский

Citations

0
Artificial Human Blood Vessels for Tissue Engineering DOI
Yi Zhang,

Lina Lin,

Mengying Niu

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1626 - 1645

Published: March 27, 2025

Language: Английский

Citations

0
Localized Cancer Treatment Using Thiol–Ene Hydrogels for Dual Drug Delivery DOI Creative Commons

Lakshmi Sathi Devi,

Maria Rosa Gigliobianco, Serena Gabrielli

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% 33%). Rheological analysis confirmed enhanced viscoelasticity increasing (99Gel-33 > 99Gel-16 23Gel-33 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) carvacrol (CRV), exhibiting tumor-responsive degradation tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% PBS), while CRV showed an initial burst followed sustained promoted mesenchymal stem cell proliferation effectively inhibited triple-negative breast cells. injectable, offers promising platform minimally invasive, personalized therapy.

Language: Английский

Citations

0
Loading of hyaluronic acid–conjugated MoS2 nanosheets with rhodamine B for sensing hyaluronidase activity in human urine and live cells DOI

Aravindan Varatharajan,

Chia-Chi Chang, Wei‐Lung Tseng

et al.

Talanta, Journal Year: 2025, Volume and Issue: 293, P. 128110 - 128110

Published: April 10, 2025

Language: Английский

Citations

0
Engineering extracellular matrix-based hydrogels for intervertebral disc regeneration DOI Creative Commons

Mwafaq Kmail,

Rusydi Mohd Razak,

Isma Liza Mohd Isa

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

Lower back pain (LBP) is a major health concern, especially in older adults. A key aetiological factor intervertebral disc (IVD) degeneration. It mediated by dysregulation of extracellular matrix (ECM) and inflammation. In recent years, regenerative therapies have garnered attention for their potential to restore function addressing the underlying biological alterations within IVD. This review focuses on comprehensive understanding anatomy physiology IVD, highlighting its life cycle from embryonic development, maturation degenerative phenotype. We describe current treatments managing LBP caused IVD emphasizes advancements hydrogel engineering, natural, synthetic, composite hydrogels application ECM-targeted therapy By exploring innovations technology, including improvements crosslinking techniques controlled degradation rates—we discuss how these materials could enhance regeneration potentially be used management LBP. With enhanced biomimicry, hydrogel-based ECM mimics offer promising pathway developing effective, durable that address root causes degeneration, providing new hope individuals living with chronic

Language: Английский

Citations

0
Self-assembled hyaluronic acid nanoparticles for the topical treatment of inflammatory skin diseases: Beyond drug carriers DOI
Wang‐Hee Lee, Wook Kim

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 366, P. 114 - 127

Published: Dec. 30, 2023

Language: Английский

Citations

10
Graded Modulation of Inflammation by Metal Ion-Coordinated Peptide-Based Hydrogel Chemical Regulators Promotes Tendon–Bone Junction Regeneration DOI

Renxuan Li,

Renhao Yang, Yin Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(35), P. 46145 - 46158

Published: Aug. 24, 2024

After rotator cuff injuries, uncontrolled inflammation hinders tendon–bone junction regeneration and induces scar formation in situ. Therefore, precisely controlling could be a solution to accelerate regeneration. In this study, we synthesized peptide–metal ion complex hydrogel with thermosensitive capability that can used as chemical regulator. By the coordination between Mg2+ BMP-12, free coordinated programmability released from hydrogel. The fast release of prevent at early stage according results RT-qPCR immunofluorescence staining. Then, was slowly provided an anti-inflammatory environment for long term. Finally, demonstrated enhanced therapeutic effects rat tear model. Overall, Mg2+/BMP-12 complex-based effectively addresses regenerative requirements across various stages by graded modulating inflammation.

Language: Английский

Citations

3