Biomaterials, Год журнала: 2024, Номер 317, С. 123059 - 123059
Опубликована: Дек. 26, 2024
Язык: Английский
APOPTOSIS, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 10, 2024
Язык: Английский
Процитировано
10
Regenerative Biomaterials, Год журнала: 2025, Номер 12
Опубликована: Янв. 1, 2025
Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.
Язык: Английский
Процитировано
1
Biomedical Technology, Год журнала: 2024, Номер 8, С. 17 - 49
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
4
Composites Part B Engineering, Год журнала: 2024, Номер unknown, С. 111928 - 111928
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
4
Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112165 - 112165
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113610 - 113610
Опубликована: Март 7, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Май 19, 2025
Abstract Fibrotic skin diseases are characterized by excessive fibroblast proliferation and pathological extracellular matrix deposition. As a pivotal coenzyme in cellular energetics, NAD homeostasis perturbation is implicated fibrosis. Multiple studies have demonstrated the therapeutic potential of mesenchymal stem cells (MSCs) against cutaneous fibrosis, while specific mechanism remains elusive. Herein, this work finds that although almost all MSCs undergo situ apoptosis within 24 h post‐subcutaneous administration, MSC‐derived apoptotic bodies (ABs) mediated potent anti‐fibrotic effects. Mechanistically, ABs can restore mitochondrial through NAMPT transfer, FOXO1 deacetylation enhancement, PINK1/PARKIN‐dependent mitophagy activation. To achieve penetration into hard fibrotic skin, permeable (pABs) constructed via metabolic glycoengineering copper‐free click chemistry techniques. In both keloid xenograft scleroderma murine models, pABs significantly penetrate collagen reduce summary, research establishes highly promising strategy for reversing fibrosis with matrix.
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2024, Номер 317, С. 123059 - 123059
Опубликована: Дек. 26, 2024
Язык: Английский
Процитировано
2