Formulation Advances in Posterior Segment Ocular Drug Delivery
Journal of Ocular Pharmacology and Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Posterior
segment
ocular
diseases,
such
as
diabetic
retinopathy,
age-related
macular
degeneration,
and
retinal
vein
occlusion,
are
leading
causes
of
vision
impairment
blindness
worldwide.
Effective
management
these
conditions
remains
a
formidable
challenge
due
to
the
unique
anatomical
physiological
barriers
eye,
including
blood-retinal
barrier
rapid
drug
clearance
mechanisms.
To
address
hurdles,
nanostructured
delivery
systems
proposed
overcome
barriers,
target
retina,
enhance
permeation
while
ensuring
controlled
release.
Traditional
therapeutic
approaches,
intravitreal
injections,
pose
significant
drawbacks,
patient
discomfort,
poor
compliance,
potential
complications.
Therefore,
understanding
physiology
mechanism
eye
could
aid
in
design
novel
formulations
that
be
noninvasive
deliver
drugs
reach
site
is
pivotal
for
effective
treatment
strategies.
This
review
focuses
on
recent
advances
formulation
strategies
posterior
delivery,
highlighting
their
limitations.
Furthermore,
nanocarrier
in-situ
gel,
niosomes,
hydrogels,
dendrimers,
liposomes,
nanoparticles,
nanoemulsions
more
effectively
selectively
explored,
supplemented
with
illustrative
examples,
figures,
tables.
aims
provide
insights
into
current
state
emphasizing
need
interdisciplinary
approaches
develop
patient-centric,
minimally
invasive,
solutions.
Язык: Английский
A novel sulfur‐containing photoinitiator based on benzophenone derivatives for rapid photopolymerization
Smart Molecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
Abstract
In
this
study,
a
series
of
benzophenone
(BP)‐based
photoinitiators
(PIs),
designated
as
BP‐Sn,
were
synthesized
by
the
integration
small
molecule
hydrogen
donors
into
BP
scaffold.
This
design
aims
to
minimize
reliance
on
co‐initiators,
reduce
potential
odors
and
toxicities,
enhance
initiation
efficiency
PIs
under
LED
irradiation.
Additionally,
incorporation
thioether
linkages
imparts
distinctive
dual
functionality
PIs,
enabling
them
exhibit
both
hydrogen‐abstracting
(Type
II)
bond‐breaking
I)
characteristics.
The
photophysical
photoinitiation
properties
BP‐Sn
evaluated
using
electron
paramagnetic
resonance,
UV‐visible
spectrophotometry,
real‐time
Fourier‐transform
Infrared
spectroscopy.
findings
demonstrate
that
remarkable
efficacy
single‐component
PI
for
free‐radical
polymerization,
achieving
final
conversion
approaching
95%
rate
exceeding
20%
s
−1
polymerization
tripropylene
glycol
diacrylate
without
need
additional
co‐initiators.
Furthermore,
experiment
revealed
exposure
365
nm
light
just
2
min
results
in
formation
colorless
well‐defined
patterned
texture,
with
thickness
5
mm
diameter
7
cm,
demonstrating
its
practical
applications.
Язык: Английский
Drug Repurposing: Unique Carbon Dot Antibacterial Films for Fruit Postharvest Preservation
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Fruit
spoilage
caused
by
oxidation
and
microbial
infection
exacerbates
resource
wastage.
Although
starch
films
including
chitosan
possessed
admirable
biocompatibility
owing
to
great
biodegradability
compared
with
conventional
plastics,
deficient
antibacterial
antioxidant
capacity
restricted
food
shelf
life.
Herein,
an
environmentally
friendly
film
(CS/G-CDs)
was
constructed
carbon
dots
derived
from
Cirsii
Herba
(CDs),
which
formed
through
high
affinity
resulting
hydrogen
bonding
between
molecules
hydroxyl
originating
CDs.
The
prepared
CDs
presented
homogeneous
monodisperse
spherical
structures
ultrasmall
size,
providing
favorable
conditions
for
uniform
formation.
Encouragingly,
the
of
CS/G-CDs
increased
5.00-fold,
followed
rate
up
97.0%.
Dramatically,
revealed
glorious
UV
shielding
efficacy
(99.9%
UVB
98.2%
UVA),
its
preservation
time
blueberries
remarkably
extended
8
days
longer
than
that
film.
Overall,
Chinese
herb-derived
exhibited
magnified
antibacterial/antioxidant
properties
biocompatibility,
provided
a
promising
strategy
sustainable
development
packaging
materials.
Язык: Английский
Dynamic silicone hydrogel gauze coatings with dual anti-blood adhesion mechanism for rapid hemostasis and minimal secondary damage
Science Advances,
Год журнала:
2024,
Номер
10(49)
Опубликована: Дек. 6, 2024
Hemostatic
materials
that
can
rapidly
control
bleeding
without
causing
secondary
damage
or
sharp
pain
upon
removal
are
receiving
increasing
demands
in
acute
trauma
treatments
and
first-aid
supplies.
Here,
we
report
the
development
of
a
dynamic
silicone
hydrogel
coating
on
medical
gauze
to
enable
rapid
hemostasis
synergistic
anti-blood
adhesion
properties.
The
spontaneously
form
oriented
cross-linked
structures
fibrous
through
solution-processing
method
achieve
macroscopic
superhydrophobicity
with
microscopic
surface
slipperiness,
resulting
excellent
on-wound
peeling
force
at
~0
millinewton.
enables
unique
integration
advanced
features
including
instant
control,
adhesion,
air
permeability.
proposed
strategy
is
also
suitable
for
scalable
production,
making
it
promising
applications
management.
Язык: Английский
Photoswitchable Spiropyridine Enabled Photoactuation of Polymeric Hydrogels under Physiological pH Conditions
Chinese Journal of Polymer Science,
Год журнала:
2024,
Номер
42(10), С. 1602 - 1609
Опубликована: Авг. 27, 2024
Язык: Английский
TRPV1-targeted ion-responsive hydrogel against pyroptosis of dry eye disease
Chemical Engineering Journal,
Год журнала:
2024,
Номер
unknown, С. 156155 - 156155
Опубликована: Сен. 1, 2024
Язык: Английский
Transforming growth factor-β1-loaded RADA-16 hydrogel scaffold for effective cartilage regeneration
Colloids and Surfaces B Biointerfaces,
Год журнала:
2024,
Номер
239, С. 113959 - 113959
Опубликована: Май 10, 2024
Язык: Английский
Multicolor Management of Smart Fluorescent Polymeric Hydrogels
Fundamental Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Fluorescent
polymeric
hydrogels
(FPHs)
are
rising
stars
of
luminescent
materials
because
their
considerable
prospects
in
a
wide
range
advancing
domains.
However,
challenges
exist
broadening
color
tunability,
which
is
the
key
to
developing
multicolor
FPHs
(MFPHs)
for
actual
applications
cutting-edge
frontiers.
In
this
perspective,
we
summarize
state-of-the-art
strategies
fabricating
MFPHs
and
discuss
remaining
challenges.
Язык: Английский
Management and repair strategies for abdominal perforations during abdominoplasty innovative techniques and clinical outcomes: a systematic review
International Journal of Research in Medical Sciences,
Год журнала:
2024,
Номер
12(8), С. 2962 - 2968
Опубликована: Июль 31, 2024
Current
suture
advancements
in
abdominoplasty
and
abdominal
perforation
repair
have
enhanced
surgical
outcomes.
Innovations
include
antimicrobial
sutures,
which
use
agents
like
triclosan
silver
nanoparticles
to
reduce
site
infections
without
compromising
integrity.
Drug-eluting
sutures
release
therapeutic
directly
at
the
wound
promote
healing
reducing
need
for
systemic
medications.
Bioactive
those
seeded
with
stem
cells
aid
tissue
regeneration
promising
confirmed
success
complex
surgeries.
Smart
featuring
shape-memory
polymers
electronic
that
monitor
physiological
parameters
represent
cutting-edge
developments.
Barbed
eliminate
knots,
distribute
tension
evenly,
decrease
operative
time.
Mesh
techniques
come
biocompatible
materials
enhancing
integration
complications.
Endoscopic
laparoscopic
approaches
augmented
by
artificial
intelligence
further
refined
repairs
offer
superior
Fibrin
sealants
adhesives
also
seen
improvements
efficacy,
safety,
biocompatibility,
advances
synthetic
alternatives
bioactive
formulations
success.
Язык: Английский
Advancements in hydrogel technology for ocular drug delivery
Опубликована: Дек. 12, 2024
Hydrogel-based
drug
delivery
systems
(DDS)
offer
promising
alternatives
for
treating
ocular
diseases
by
overcoming
the
limitations
of
traditional
therapies,
such
as
low
bioavailability,
frequent
administration,
and
invasiveness.
Hydrogels,
with
their
high
biocompatibility
ability
to
respond
external
stimuli,
can
provide
sustained
targeted
delivery.
This
review
highlights
unique
properties
hydrogels,
including
swelling
behavior,
porosity,
mechanical
strength,
making
them
suitable
various
applications.
The
classification
hydrogels
based
on
cross-linking
methods,
origins,
stimuli
responsiveness
is
discussed,
emphasizing
potential
in
dry
eye
disease
(DED),
glaucoma,
corneal
alkali
burns,
neovascularization.
Notable
advances
include
thermosensitive
pH-responsive
which
have
shown
results
preclinical
studies.
Despite
these
advances,
most
studies
are
still
stages,
highlighting
need
rigorous
human
trials
validate
safety
efficacy
hydrogel
DDS.
Collaborative
efforts
among
researchers,
pharmacologists,
ophthalmologists
essential
translating
innovations
into
clinical
practice,
ultimately
improving
patient
outcomes
management.
Язык: Английский